Cross-sectional and longitudinal changes in category-selectivity in visual cortex following pediatric cortical resection DOI Creative Commons
Tina T. Liu, Michael C. Granovetter, Anne Margarette S. Maallo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract The topographic organization of category-selective responses in human ventral occipitotemporal cortex (VOTC) and its relationship to regions subserving language functions is remarkably uniform across individuals. This arrangement thought result from the clustering neurons responding similar inputs, constrained by intrinsic architecture tuned experience. We examined malleability this individuals with unilateral resection VOTC during childhood for management drug-resistant epilepsy. In cross-sectional longitudinal functional imaging studies, we compared topography neural representations 17 a resection, ‘control patient’ outside VOTC, typically developing matched controls. demonstrated both adherence deviation standard uncovered fine-grained competitive dynamics between word- face-selectivity over time single, preserved VOTC. findings elucidate nature extent cortical plasticity highlight potential remodeling extrastriate function. Teaser After pediatric deviations constraints visual reflect plasticity.

Language: Английский

Space- and object-based attention in patients with a single hemisphere following childhood resection DOI Creative Commons
Sophia Robert, Michael C. Granovetter, Shouyu Ling

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract The neural processes underlying attentional processing are typically lateralized in adults, with spatial attention associated the right hemisphere (RH) and object-based left (LH). Using a modified two-rectangle paradigm, we compared lateralization profiles of individuals childhood hemispherectomy (either LH or RH) age-matched, developing controls. Although patients exhibited slower reaction times (RTs) to controls, both groups benefited from valid cueing. However, experienced significantly higher costs for invalid trials—reflected by larger RT differences between validly invalidly cued targets. This was true trials on uncued objects, probes object- space-based processes, respectively. Notably, controls showed no significant cost locations versus objects. By contrast, greater targets suggesting difficulty shifting across We explore potential explanations this group difference lack RH resection. These findings enhance our understanding typical development reveal how injury affects systems RH.

Language: Английский

Citations

0
Cross-sectional and longitudinal changes in category-selectivity in visual cortex following pediatric cortical resection DOI Creative Commons
Tina T. Liu, Michael C. Granovetter, Anne Margarette S. Maallo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract The topographic organization of category-selective responses in human ventral occipitotemporal cortex (VOTC) and its relationship to regions subserving language functions is remarkably uniform across individuals. This arrangement thought result from the clustering neurons responding similar inputs, constrained by intrinsic architecture tuned experience. We examined malleability this individuals with unilateral resection VOTC during childhood for management drug-resistant epilepsy. In cross-sectional longitudinal functional imaging studies, we compared topography neural representations 17 a resection, ‘control patient’ outside VOTC, typically developing matched controls. demonstrated both adherence deviation standard uncovered fine-grained competitive dynamics between word- face-selectivity over time single, preserved VOTC. findings elucidate nature extent cortical plasticity highlight potential remodeling extrastriate function. Teaser After pediatric deviations constraints visual reflect plasticity.

Language: Английский

Citations

0