Genomic surveillance and molecular evolution of fungicide resistance in European populations of wheat powdery mildew DOI Creative Commons
Nikolaos Minadakis,

Jigisha Jigisha,

Luca Cornetti

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Abstract Fungicides are used in agriculture to manage fungal infections and maintain crop yield quality. In Europe, their application on cereals increased drastically starting from the mid 1970s, contributing a significant improvement yields. However, extensive usage has led rapid evolution of resistant pathogen populations within just few years fungicide deployment. Here we focus wheat powdery mildew, disease caused by ascomycete fungus Blumeria graminis forma specialis tritici (Bgt). Previous research Bgt documented emergence resistance different fungicides identified various mechanisms. Yet, frequency, distribution, evolutionary dynamics remain largely unexplored. this study leveraged sampling whole-genome sequencing Europe Mediterranean investigate population genetics molecular epidemiology towards five major classes. We analyzed gene sequences copy number variation eight known target genes 415 isolates sampled between 1980 2023. observed that mutations conferring frequency over time, had distinct geographic distributions, likely due diverse deployment across regions. For demethylation inhibitor multiple independent events with mutational profiles, tracked spread last decades. Overall, revealed epidemiological European populations. These results underscore potential genomic surveillance enhance our understanding resistance.

Language: Английский

Genomic Surveillance and Molecular Evolution of Fungicide Resistance in European Populations of Wheat Powdery Mildew DOI Creative Commons
Nikolaos Minadakis,

Jigisha Jigisha,

Luca Cornetti

et al.

Molecular Plant Pathology, Journal Year: 2025, Volume and Issue: 26(3)

Published: March 1, 2025

ABSTRACT Fungicides are used in agriculture to manage fungal infections and maintain crop yield quality. In Europe, their application on cereals increased drastically starting from the mid 1970s, contributing a significant improvement yields. However, extensive usage has led rapid evolution of resistant pathogen populations within just few years fungicide deployment. Here we focus wheat powdery mildew, disease caused by ascomycete fungus Blumeria graminis forma specialis tritici (Bgt). Previous research Bgt documented emergence resistance different fungicides identified various mechanisms. Yet, frequency, distribution evolutionary dynamics remain largely unexplored. this study, leveraged sampling whole‐genome sequencing Europe Mediterranean investigate population genetics molecular epidemiology towards five major classes. We analysed gene sequences copy number variation eight known target genes 415 isolates sampled between 1980 2023. observed that mutations conferring frequency over time had distinct geographic distributions, probably due diverse deployment across regions. For demethylation inhibitor fungicides, multiple independent events with mutational profiles, tracked spread last decades. Overall, revealed epidemiological European populations. These results underscore potential genomic surveillance enhance our understanding resistance.

Language: Английский

Citations

0
Genomic surveillance and molecular evolution of fungicide resistance in European populations of wheat powdery mildew DOI Creative Commons
Nikolaos Minadakis,

Jigisha Jigisha,

Luca Cornetti

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Abstract Fungicides are used in agriculture to manage fungal infections and maintain crop yield quality. In Europe, their application on cereals increased drastically starting from the mid 1970s, contributing a significant improvement yields. However, extensive usage has led rapid evolution of resistant pathogen populations within just few years fungicide deployment. Here we focus wheat powdery mildew, disease caused by ascomycete fungus Blumeria graminis forma specialis tritici (Bgt). Previous research Bgt documented emergence resistance different fungicides identified various mechanisms. Yet, frequency, distribution, evolutionary dynamics remain largely unexplored. this study leveraged sampling whole-genome sequencing Europe Mediterranean investigate population genetics molecular epidemiology towards five major classes. We analyzed gene sequences copy number variation eight known target genes 415 isolates sampled between 1980 2023. observed that mutations conferring frequency over time, had distinct geographic distributions, likely due diverse deployment across regions. For demethylation inhibitor multiple independent events with mutational profiles, tracked spread last decades. Overall, revealed epidemiological European populations. These results underscore potential genomic surveillance enhance our understanding resistance.

Language: Английский

Citations

0