Increased CRF-R1 transmission in the nucleus accumbens shell facilitates maternal neglect in lactating rats and mediates anxiety-like behaviour in a sex-specific manner DOI Creative Commons
Alice Sanson, Luisa Demarchi,

Emma Rocaboy

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 110256 - 110256

Published: Dec. 1, 2024

During the transition to motherhood, complex brain adaptations occur ensure adequate maternal responses offspring' needs accompanied by reduced anxiety. Among others, corticotropin-releasing factor (CRF) and oxytocin (OXT) systems have emerged as crucial regulators of these essential postpartum adaptations. Here, we investigated their roles within nucleus accumbens shell (NAcSh), a central region reward circuits, in neglect lactating rats. Furthermore, assessed contribution local CRF system anxiety-like behaviour, comparing female, virgin female male rats evaluate potential sex-differences. Increasing receptor (CRF-R) 1 transmission via infusion NAcSh led neglect, reducing nursing increasing self-directed behaviours. In turn, CRF-R1 inhibition impaired motivation. Intra-NAcSh UCN3 did not promote but increased behaviour rats, whereas had anxiogenic effects only Crh-r1 mRNA expression was higher compared females; furthermore, Crh-bp only. Lastly, pharmacological manipulations OXT affect responses. conclusion, finely balanced signalling is required for proper Dampened CRF-R2 prevents onset plays more prominent role males, highlighting sex-differences system's regulation anxiety NAcSh.

Language: Английский

Increased CRF-R1 transmission in the nucleus accumbens shell facilitates maternal neglect in lactating rats and mediates anxiety-like behaviour in a sex-specific manner DOI Creative Commons
Alice Sanson, Luisa Demarchi,

Emma Rocaboy

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 110256 - 110256

Published: Dec. 1, 2024

During the transition to motherhood, complex brain adaptations occur ensure adequate maternal responses offspring' needs accompanied by reduced anxiety. Among others, corticotropin-releasing factor (CRF) and oxytocin (OXT) systems have emerged as crucial regulators of these essential postpartum adaptations. Here, we investigated their roles within nucleus accumbens shell (NAcSh), a central region reward circuits, in neglect lactating rats. Furthermore, assessed contribution local CRF system anxiety-like behaviour, comparing female, virgin female male rats evaluate potential sex-differences. Increasing receptor (CRF-R) 1 transmission via infusion NAcSh led neglect, reducing nursing increasing self-directed behaviours. In turn, CRF-R1 inhibition impaired motivation. Intra-NAcSh UCN3 did not promote but increased behaviour rats, whereas had anxiogenic effects only Crh-r1 mRNA expression was higher compared females; furthermore, Crh-bp only. Lastly, pharmacological manipulations OXT affect responses. conclusion, finely balanced signalling is required for proper Dampened CRF-R2 prevents onset plays more prominent role males, highlighting sex-differences system's regulation anxiety NAcSh.

Language: Английский

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