Relationships between wellbeing polygenic scores, brain structure, and psychopathology in children DOI Creative Commons
Christian K. Tamnes, Andreas Dahl, Dennis van der Meer

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Wellbeing is shaped by an interplay of genetic and environmental factors associated with both health functioning. It remains unclear whether influences on wellbeing are linked to brain structure and, in turn, early-life psychopathology. Here, we investigated associations between polygenic scores (PGS), magnetic resonance imaging (MRI)-derived measures structure, parent-reported child psychopathology a large cross-sectional sample children from the Adolescent Brain Cognitive Development (ABCD) Study (n = 8844; 8.9-11.0 years old). Preregistered analyses revealed no significant PGS regional cortical thickness or subcortical volumes only small negative association surface area parahippocampal cortex (β -0.03, p=.002), while exploratory analysis identified positive intracranial volume (ICV; β 0.04, p<.001). showed general -0.09, p<.001) internalizing externalizing problems -0.07, ICV partially mediated relationships psychopathology, accounting for 1.3-3.3% these relationships. The findings suggest that have limited children, they exhibit protective effects against Highlights show children. Negative found area. Positive volume. lower levels Intracranial mediate PGS-psychopathology associations.

Language: Английский

Relationships between wellbeing polygenic scores, brain structure, and psychopathology in children DOI Creative Commons
Christian K. Tamnes, Andreas Dahl, Dennis van der Meer

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Wellbeing is shaped by an interplay of genetic and environmental factors associated with both health functioning. It remains unclear whether influences on wellbeing are linked to brain structure and, in turn, early-life psychopathology. Here, we investigated associations between polygenic scores (PGS), magnetic resonance imaging (MRI)-derived measures structure, parent-reported child psychopathology a large cross-sectional sample children from the Adolescent Brain Cognitive Development (ABCD) Study (n = 8844; 8.9-11.0 years old). Preregistered analyses revealed no significant PGS regional cortical thickness or subcortical volumes only small negative association surface area parahippocampal cortex (β -0.03, p=.002), while exploratory analysis identified positive intracranial volume (ICV; β 0.04, p<.001). showed general -0.09, p<.001) internalizing externalizing problems -0.07, ICV partially mediated relationships psychopathology, accounting for 1.3-3.3% these relationships. The findings suggest that have limited children, they exhibit protective effects against Highlights show children. Negative found area. Positive volume. lower levels Intracranial mediate PGS-psychopathology associations.

Language: Английский

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