bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 5, 2025
Abstract Aligning genomes into common coordinates is central to pangenome analysis and construction, but it also computationally expensive. Multi-sequence maximal unique matches (multi-MUMs) are guideposts for core genome alignments, helping frame solve the multiple alignment problem. We introduce Mumemto, a tool that computes multi-MUMs other match types across large pangenomes. Mumemto allows visualization of synteny, reveals aberrant assemblies scaffolds, highlights conservation structural variation. 320 human (960GB) in 25.7 hours with under 800 GB memory, over hundreds fungal minutes. implemented C++ Python available open-source at https://github.com/vikshiv/mumemto .
Language: Английский