Autophagy and Respiratory Viruses: Mechanisms, Viral Exploitation, and Therapeutic Insights DOI Creative Commons
Farnaz Aligolighasemabadi,

Estera Bakinowska,

Kajetan Kiełbowski

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 418 - 418

Published: March 12, 2025

Respiratory viruses, such as influenza virus, rhinovirus, coronavirus, and respiratory syncytial virus (RSV), continue to impose a heavy global health burden. Despite existing vaccination programs, these infections remain leading causes of morbidity mortality, especially among vulnerable populations like children, older adults, immunocompromised individuals. However, the current therapeutic options for viral are often limited supportive care, underscoring need novel treatment strategies. Autophagy, particularly macroautophagy, has emerged fundamental cellular process in host response infections. This not only supports homeostasis by degrading damaged organelles pathogens but also enables xenophagy, which selectively targets particles degradation enhances defense. viruses have evolved mechanisms manipulate autophagy pathways, using them evade immune detection promote replication. review examines dual role manipulation defense, focusing on complex interplay between autophagy-related pathways. By elucidating mechanisms, we aim highlight potential targeting enhance antiviral responses, offering promising directions development effective treatments against

Language: Английский

Autophagy and Respiratory Viruses: Mechanisms, Viral Exploitation, and Therapeutic Insights DOI Creative Commons
Farnaz Aligolighasemabadi,

Estera Bakinowska,

Kajetan Kiełbowski

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 418 - 418

Published: March 12, 2025

Respiratory viruses, such as influenza virus, rhinovirus, coronavirus, and respiratory syncytial virus (RSV), continue to impose a heavy global health burden. Despite existing vaccination programs, these infections remain leading causes of morbidity mortality, especially among vulnerable populations like children, older adults, immunocompromised individuals. However, the current therapeutic options for viral are often limited supportive care, underscoring need novel treatment strategies. Autophagy, particularly macroautophagy, has emerged fundamental cellular process in host response infections. This not only supports homeostasis by degrading damaged organelles pathogens but also enables xenophagy, which selectively targets particles degradation enhances defense. viruses have evolved mechanisms manipulate autophagy pathways, using them evade immune detection promote replication. review examines dual role manipulation defense, focusing on complex interplay between autophagy-related pathways. By elucidating mechanisms, we aim highlight potential targeting enhance antiviral responses, offering promising directions development effective treatments against

Language: Английский

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