Understanding and targeting repetitive behaviors and restricted interests in autism spectrum disorder via high-definition transcranial direct current stimulation: a study-protocol DOI Creative Commons
Giulia Lazzaro,

Sara Passarini,

Andrea Battisti

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 25, 2025

Autism spectrum disorder (ASD) is a neurodevelopmental characterized by persistent deficits in social interaction and repetitive behaviors (RBs). Therapies specifically targeting RBs have been underexplored despite advances understanding their neurobiological basis. This study aims to evaluate whether high-definition transcranial direct current stimulation (HD-tDCS) can reduce dysfunctional autistic children investigate improvements differ between lower-order higher-order based on the brain regions stimulated. The entails multi-session, sham-controlled, site-controlled, double-blind, between-subjects design. will include participants with an ASD diagnosis (aged 8–13 years; IQ ≥ 70), who undergo HD-tDCS intervention for 10 sessions. Participants be randomly assigned three conditions: (1) Pre-Motor Active Group (active over pre-SMA cortex); (2) Frontal dlPFC); (3) Placebo Control Group. In active conditions, delivered through 4 × 1 montage; small circular electrodes used cathode placed centrally intensity of 0.5 mA total 20 min (30 s ramp up/down) per session. during sham condition same procedures as those both conditions actual placement electrodes, turning equipment s). assessment completed at baseline (T0), immediately after end (T1) 3 months (T2). primary outcome measure Total Score Repetitive Behavior Scale-Revised. secondary outcomes measures comprise symptoms, sensory processing pattern, emotional/behavioral problems, sleep functioning, parental stress, neuropsychological features High-Density EEG connectivity. We hypothesize that lead significant reduction score compared Sham Group, site-specific effects RBs. easy-to-deliver, time-efficient, neurobiologically-driven could performed add-on time conventional therapy ASD. Given inherent limitations specific interventions RBs, tDCS represents important "third" treatment arm address burden trial has registered ClinicalTrials.gov (ID: NCT06645587). Registered 17 October 2024.

Language: Английский

Understanding and targeting repetitive behaviors and restricted interests in autism spectrum disorder via high-definition transcranial direct current stimulation: a study-protocol DOI Creative Commons
Giulia Lazzaro,

Sara Passarini,

Andrea Battisti

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 25, 2025

Autism spectrum disorder (ASD) is a neurodevelopmental characterized by persistent deficits in social interaction and repetitive behaviors (RBs). Therapies specifically targeting RBs have been underexplored despite advances understanding their neurobiological basis. This study aims to evaluate whether high-definition transcranial direct current stimulation (HD-tDCS) can reduce dysfunctional autistic children investigate improvements differ between lower-order higher-order based on the brain regions stimulated. The entails multi-session, sham-controlled, site-controlled, double-blind, between-subjects design. will include participants with an ASD diagnosis (aged 8–13 years; IQ ≥ 70), who undergo HD-tDCS intervention for 10 sessions. Participants be randomly assigned three conditions: (1) Pre-Motor Active Group (active over pre-SMA cortex); (2) Frontal dlPFC); (3) Placebo Control Group. In active conditions, delivered through 4 × 1 montage; small circular electrodes used cathode placed centrally intensity of 0.5 mA total 20 min (30 s ramp up/down) per session. during sham condition same procedures as those both conditions actual placement electrodes, turning equipment s). assessment completed at baseline (T0), immediately after end (T1) 3 months (T2). primary outcome measure Total Score Repetitive Behavior Scale-Revised. secondary outcomes measures comprise symptoms, sensory processing pattern, emotional/behavioral problems, sleep functioning, parental stress, neuropsychological features High-Density EEG connectivity. We hypothesize that lead significant reduction score compared Sham Group, site-specific effects RBs. easy-to-deliver, time-efficient, neurobiologically-driven could performed add-on time conventional therapy ASD. Given inherent limitations specific interventions RBs, tDCS represents important "third" treatment arm address burden trial has registered ClinicalTrials.gov (ID: NCT06645587). Registered 17 October 2024.

Language: Английский

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