Toxoplasma gondii, endothelial cells and schizophrenia: is it just a barrier matter? DOI Creative Commons
Victoria Cruz Cavalari, Luiz Fernando Cardoso Garcia, Raffael Massuda

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 10, 2025

Toxoplasma gondii is an obligatory intracellular parasite responsible for causing toxoplasmosis. It estimated that approximately one-third of the world's population has positive serology Acute T. infection often results in subtle symptoms because its nonspecific nature. Owing to immune pressure, parasites tend encyst and persist different tissues organs, such as brain, chronicling infection. While most chronically infected individuals do not develop significant symptoms, can affect central nervous system (CNS), leading range from dizziness behavioral changes. To reach CNS, must overcome blood-brain barrier, which composed primarily endothelial cells. these cells are typically efficient at separating blood elements infection, they only permit parasitic colonization CNS but also contribute inflammatory profile may exacerbate previously established conditions both local systemic levels. An increasing body research demonstrated a potential link between by cellular or humoral response with worsening psychiatric conditions, schizophrenia. Therefore, continually advancing aimed understanding mitigating relationship schizophrenia imperative.

Language: Английский

Toxoplasma gondii, endothelial cells and schizophrenia: is it just a barrier matter? DOI Creative Commons
Victoria Cruz Cavalari, Luiz Fernando Cardoso Garcia, Raffael Massuda

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 10, 2025

Toxoplasma gondii is an obligatory intracellular parasite responsible for causing toxoplasmosis. It estimated that approximately one-third of the world's population has positive serology Acute T. infection often results in subtle symptoms because its nonspecific nature. Owing to immune pressure, parasites tend encyst and persist different tissues organs, such as brain, chronicling infection. While most chronically infected individuals do not develop significant symptoms, can affect central nervous system (CNS), leading range from dizziness behavioral changes. To reach CNS, must overcome blood-brain barrier, which composed primarily endothelial cells. these cells are typically efficient at separating blood elements infection, they only permit parasitic colonization CNS but also contribute inflammatory profile may exacerbate previously established conditions both local systemic levels. An increasing body research demonstrated a potential link between by cellular or humoral response with worsening psychiatric conditions, schizophrenia. Therefore, continually advancing aimed understanding mitigating relationship schizophrenia imperative.

Language: Английский

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