Unlocking the power of probiotics, postbiotics: targeting apoptosis for the treatment and prevention of digestive diseases

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 31, 2025

Digestive diseases are becoming an increasingly serious health burden, creating urgent need to develop more effective treatment strategies. Probiotics and postbiotics have been extensively studied for their potential prevent treat digestive diseases. Growing evidence suggests that programmed cell death, especially apoptosis, is a critical mechanism influencing the molecular biological aspects of diseases, contributing disease progression. Understanding mechanisms signaling pathways by which probiotics regulate apoptosis could reveal new therapeutic targets treating This review focuses on beneficial effects in regulating across range liver including non-alcoholic fatty disease, injury, cirrhosis, cancer. It also explores gastrointestinal such as colorectal cancer, colitis, infectious diarrhea. Furthermore, some help balance gut microbiota, enhance intestinal barrier function, immune system, all closely associated with apoptosis. Moreover, emerging technologies, encapsulation methods, developed stabilize probiotics, primarily based experimental findings from rodent human studies.

Language: Английский

Protein shapeshifting in necroptotic cell death signaling

Trends in Biochemical Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский