Molecular and Biophysical Perspectives on Dormancy Breaking: Lessons from Yeast Spore DOI Creative Commons
Keiichiro Sakai, Yohei Kondo, Kazuhiro Aoki

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 701 - 701

Published: May 11, 2025

Dormancy is a physiological state that enables cells to survive under adverse conditions by halting their proliferation while retaining the capacity resume growth when become favorable. This remarkable transition between dormant and proliferative states occurs across wide range of species, including bacteria, fungi, plants, tardigrades. Among these organisms, yeast have emerged as powerful model systems for elucidating molecular biophysical principles governing dormancy breaking. In this review, we provide comprehensive summary current knowledge on mechanisms underlying cellular dormancy, with particular focus two major yeasts: Saccharomyces cerevisiae Schizosaccharomyces pombe. Recent advances in multifaceted approaches—such single-cell RNA-seq, proteomic analysis, live-cell imaging—have revealed dynamic changes gene expression, proteome composition, viability. Furthermore, insights into properties cytoplasm offered new understanding cell regulation through cytoplasmic fluidity. These contribute both stability exit upon environmental cues, deepening our fundamental survival strategies diverse species.

Language: Английский

Molecular and Biophysical Perspectives on Dormancy Breaking: Lessons from Yeast Spore DOI Creative Commons
Keiichiro Sakai, Yohei Kondo, Kazuhiro Aoki

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 701 - 701

Published: May 11, 2025

Dormancy is a physiological state that enables cells to survive under adverse conditions by halting their proliferation while retaining the capacity resume growth when become favorable. This remarkable transition between dormant and proliferative states occurs across wide range of species, including bacteria, fungi, plants, tardigrades. Among these organisms, yeast have emerged as powerful model systems for elucidating molecular biophysical principles governing dormancy breaking. In this review, we provide comprehensive summary current knowledge on mechanisms underlying cellular dormancy, with particular focus two major yeasts: Saccharomyces cerevisiae Schizosaccharomyces pombe. Recent advances in multifaceted approaches—such single-cell RNA-seq, proteomic analysis, live-cell imaging—have revealed dynamic changes gene expression, proteome composition, viability. Furthermore, insights into properties cytoplasm offered new understanding cell regulation through cytoplasmic fluidity. These contribute both stability exit upon environmental cues, deepening our fundamental survival strategies diverse species.

Language: Английский

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