Atlas of nascent RNA transcripts reveals tissue-specific enhancer to gene linkages

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 25, 2025

Gene transcription is controlled and modulated by regulatory regions, including enhancers promoters. These regions are abundant in non-coding bidirectional that results generally unstable RNA. Using nascent RNA data across hundreds of human samples, we identified over 800,000 containing transcription. We then identify tissue specific, highly correlated between gene regions. The pairs, a region gene, enriched for disease associated SNPs often supported independent 3D data. present these resources as database called DBNascent ( https://nascent.colorado.edu/ ) which serves resource future studies into regulation, enhancer RNAs, factors.

Language: Английский

Does cognitive inhibition contribute to working memory and reasoning during childhood?

Psychological Research, Journal Year: 2024, Volume and Issue: 89(1)

Published: Dec. 19, 2024

Language: Английский