Gliomas organize as liquid crystals: three-dimensional nematic order, disclinations and quasi-long-range order DOI Creative Commons
Anna E. Argento, María L. Varela, Gurmukh Singh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Glioma brain tumors are structured as active nematic liquid crystals, promoting collective migration and aggression. We establish the existence of order topological defect lines loops in 3D vivo mouse human glioma tumors. As predicted by theory, sections through disclination appear ±1/2 defects 2D. In 3D, these either persist along or twist they interconvert from −1/2 to +1/2. Cell alignment exhibits quasi–long-range order, spreading throughout tumor over distances between 300−3000 μ m. vitro +1/2 display changes apoptosis levels, suggesting regulate cell density. The large scale gliomas correlates with tumors’ aggressive behavior. organization crystals provides a novel physical foundation complex solid tumors; their deconstruction signposts potential treatments for deadly cancers.

Language: Английский

Gliomas organize as liquid crystals: three-dimensional nematic order, disclinations and quasi-long-range order DOI Creative Commons
Anna E. Argento, María L. Varela, Gurmukh Singh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Glioma brain tumors are structured as active nematic liquid crystals, promoting collective migration and aggression. We establish the existence of order topological defect lines loops in 3D vivo mouse human glioma tumors. As predicted by theory, sections through disclination appear ±1/2 defects 2D. In 3D, these either persist along or twist they interconvert from −1/2 to +1/2. Cell alignment exhibits quasi–long-range order, spreading throughout tumor over distances between 300−3000 μ m. vitro +1/2 display changes apoptosis levels, suggesting regulate cell density. The large scale gliomas correlates with tumors’ aggressive behavior. organization crystals provides a novel physical foundation complex solid tumors; their deconstruction signposts potential treatments for deadly cancers.

Language: Английский

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