Control of tissue flows and embryo geometry in avian gastrulation DOI Creative Commons
Guillermo Serrano Nájera, Alex M. Plum, Benjamin Steventon

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: June 4, 2025

Abstract Embryonic tissues undergo coordinated flows during avian gastrulation to establish the body plan. Here, we elucidate how interplay between embryonic and extraembryonic affects chick embryo’s size shape. These two distinct geometric changes are each associated with dynamic curves across which trajectories separate (kinematic repellers). Through physical modeling experimental manipulations of both tissues, selectively eliminate either or repellers in model experiments, revealing their mechanistic origins. We find that embryo is affected by competition epiboly myosin-driven contraction—which persists when mesoderm induction blocked. Instead, characteristic shape change from circular pear-shaped arises cell intercalations mesendoderm, irrespective epiboly. findings modular mechanisms controlling provide a basis for independent control development.

Language: Английский

Dynamical systems of fate and form in development DOI Creative Commons
Alex M. Plum, Mattia Serra

Seminars in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 172, P. 103620 - 103620

Published: June 3, 2025

Developmental biology has long drawn on dynamical systems to understand the diverging fates and emerging form of developing embryo. Cell differentiation morphogenesis unfold in high-dimensional gene-expression spaces position spaces. Yet, their stable reproducible outcomes suggest low-dimensional geometric structures-e.g., fixed points, manifolds, dynamic attracting repelling structures-that organize cell trajectories both This review surveys history recent advances frameworks for development. We focus techniques extracting organizing structures fate decisions morphogenetic movements from experiments, as well interconnections. unifying, perspective aids rationalizing increasingly complex experimental datasets, facilitating principled dimensionality reduction an integrated understanding development, bridging typically distinct domains.

Language: Английский

Citations

0
Control of tissue flows and embryo geometry in avian gastrulation DOI Creative Commons
Guillermo Serrano Nájera, Alex M. Plum, Benjamin Steventon

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: June 4, 2025

Abstract Embryonic tissues undergo coordinated flows during avian gastrulation to establish the body plan. Here, we elucidate how interplay between embryonic and extraembryonic affects chick embryo’s size shape. These two distinct geometric changes are each associated with dynamic curves across which trajectories separate (kinematic repellers). Through physical modeling experimental manipulations of both tissues, selectively eliminate either or repellers in model experiments, revealing their mechanistic origins. We find that embryo is affected by competition epiboly myosin-driven contraction—which persists when mesoderm induction blocked. Instead, characteristic shape change from circular pear-shaped arises cell intercalations mesendoderm, irrespective epiboly. findings modular mechanisms controlling provide a basis for independent control development.

Language: Английский

Citations

0