Brain Structural and Functional Neuroimaging Features are Associated With Improved Auditory Hallucinations in Patients With Schizophrenia After Real‐Time fMRI Neurofeedback DOI Creative Commons
Jiahe Zhang,

Emma Tusuzian,

Francesca Morfini

et al.

Depression and Anxiety, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Auditory hallucinations (AHs) are debilitating and often treatment-resistant symptoms of schizophrenia (SZ). Real-time functional magnetic resonance imaging (fMRI) neurofeedback (NFB) is emerging as a flexible brain circuit-based tool for targeting AH via self-modulation activity. A better understanding what baseline characteristics predict NFB success will enhance its clinical utility. Previous work suggests that symptomology implicates measures across multiple modalities, including T1 structural MRI (sMRI), diffusion-weighted (dMRI), resting-state fMRI (rsfMRI). Specifically, severity treatment response associated with thinner superior temporal gyrus (STG), dorsolateral prefrontal cortex (DLPFC), reduced white matter integrity in tracts connecting regions implicated SZ symptomatology, increased within-default mode network (DMN) connectivity, DMN-DLPFC anticorrelation. In this study, we tested the individual combined contributions multimodal features prediction change after adults (N = 25, 36.1 ± 10.0 years, 24% females) spectrum disorders (SZ or schizoaffective disorder) frequent medication-resistant AH. Participants underwent scan (including sMRI, dMRI, rsfMRI) were randomly assigned to receive from their STG (n 12, real condition) motor (MC) 13, sham condition). was operationalized improvement NFB. We found higher severity, greater thickness, decreased dorsal cingulum integrity, within-DMN anticorrelation each individually correlated reduction severity. However, regression model, connectivity emerged only independent variable explained unique variance change. These results suggest specific rsfMRI measure, namely may be promising predictor reducing support precision medicine approach. Trial Registration: ClinicalTrials.gov identifier: NCT03504579.

Language: Английский

Brain Structural and Functional Neuroimaging Features are Associated With Improved Auditory Hallucinations in Patients With Schizophrenia After Real‐Time fMRI Neurofeedback DOI Creative Commons
Jiahe Zhang,

Emma Tusuzian,

Francesca Morfini

et al.

Depression and Anxiety, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Auditory hallucinations (AHs) are debilitating and often treatment-resistant symptoms of schizophrenia (SZ). Real-time functional magnetic resonance imaging (fMRI) neurofeedback (NFB) is emerging as a flexible brain circuit-based tool for targeting AH via self-modulation activity. A better understanding what baseline characteristics predict NFB success will enhance its clinical utility. Previous work suggests that symptomology implicates measures across multiple modalities, including T1 structural MRI (sMRI), diffusion-weighted (dMRI), resting-state fMRI (rsfMRI). Specifically, severity treatment response associated with thinner superior temporal gyrus (STG), dorsolateral prefrontal cortex (DLPFC), reduced white matter integrity in tracts connecting regions implicated SZ symptomatology, increased within-default mode network (DMN) connectivity, DMN-DLPFC anticorrelation. In this study, we tested the individual combined contributions multimodal features prediction change after adults (N = 25, 36.1 ± 10.0 years, 24% females) spectrum disorders (SZ or schizoaffective disorder) frequent medication-resistant AH. Participants underwent scan (including sMRI, dMRI, rsfMRI) were randomly assigned to receive from their STG (n 12, real condition) motor (MC) 13, sham condition). was operationalized improvement NFB. We found higher severity, greater thickness, decreased dorsal cingulum integrity, within-DMN anticorrelation each individually correlated reduction severity. However, regression model, connectivity emerged only independent variable explained unique variance change. These results suggest specific rsfMRI measure, namely may be promising predictor reducing support precision medicine approach. Trial Registration: ClinicalTrials.gov identifier: NCT03504579.

Language: Английский

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