Biopsychosocial Correlates of Resting and Stress-Reactive Salivary GDF15: Preliminary Findings DOI Creative Commons
Cynthia C. Liu, Caroline Trumpff,

Qiuhan Huang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Growth differentiation factor 15 (GDF15) is a biomarker of energetic stress related to aging, disease, and mitochondrial defects. We recently showed that GDF15 quantifiable in saliva acutely inducible by psychosocial stress. To date, the associations between biopsychosocial factors individual characteristics remain unknown. Here, sample healthy working adults ( n = 198, 70% females), we first confirmed salivary reacts acute stress, peaking 10 min following socio-evaluative paradigm (+28.3%, g 0.50, p < 0.0001). then explored i) baseline ii) reactivity variety trait- state-level including sex gender characteristics; measures mental health, burnout; physical health behaviors; anthropometric blood-based metabolic biomarkers. Baseline was higher men than women positively correlated with testosterone, while negatively estrogen traditionally feminine roles. Of examined, found work-related variables were most consistently GDF15, cynicism, burnout, emotional exhaustion predicting reactivity, job-related autonomy utilization competence predicted smaller responses. Consistent GDF15's induction renal diseases, also indirect markers disease waist-to-hip ratio, creatinine, albumin. Finally, participants greater exhibited cortisol consistent role regulation energy mobilization. Together, this exploratory analysis suggest new biological correlates, calling for large-scale studies connecting human experiences

Language: Английский

Biopsychosocial Correlates of Resting and Stress-Reactive Salivary GDF15: Preliminary Findings DOI Creative Commons
Cynthia C. Liu, Caroline Trumpff,

Qiuhan Huang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Growth differentiation factor 15 (GDF15) is a biomarker of energetic stress related to aging, disease, and mitochondrial defects. We recently showed that GDF15 quantifiable in saliva acutely inducible by psychosocial stress. To date, the associations between biopsychosocial factors individual characteristics remain unknown. Here, sample healthy working adults ( n = 198, 70% females), we first confirmed salivary reacts acute stress, peaking 10 min following socio-evaluative paradigm (+28.3%, g 0.50, p < 0.0001). then explored i) baseline ii) reactivity variety trait- state-level including sex gender characteristics; measures mental health, burnout; physical health behaviors; anthropometric blood-based metabolic biomarkers. Baseline was higher men than women positively correlated with testosterone, while negatively estrogen traditionally feminine roles. Of examined, found work-related variables were most consistently GDF15, cynicism, burnout, emotional exhaustion predicting reactivity, job-related autonomy utilization competence predicted smaller responses. Consistent GDF15's induction renal diseases, also indirect markers disease waist-to-hip ratio, creatinine, albumin. Finally, participants greater exhibited cortisol consistent role regulation energy mobilization. Together, this exploratory analysis suggest new biological correlates, calling for large-scale studies connecting human experiences

Language: Английский

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