Intraspecies dynamics underlie the apparent stability of two important skin microbiome species DOI Creative Commons
Jacob S. Baker, Evan Qu, Christopher P. Mancuso

et al.

Cell Host & Microbe, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Adult human facial skin microbiomes are remarkably similar at the species level, dominated by Cutibacterium acnes and Staphylococcus epidermidis, yet each person harbors a unique community of strains. Understanding how person-specific communities assemble is critical for designing microbiome-based therapies. Here, using 4,055 isolate genomes 356 metagenomes, we reconstruct on-person evolutionary history to reveal on- between-person strain dynamics. We find that multiple cells typically involved in transmission, indicating ample opportunity migration. Despite this accessibility, family members share only some their S. epidermidis dynamic, with persisting an average 2 years. C. strains more stable have higher colonization rate during transition adult microbiome, suggesting window could facilitate engraftment therapeutic These previously undetectable dynamics may influence design microbiome therapeutics motivate study effects on hosts.

Language: Английский

Intraspecies dynamics underlie the apparent stability of two important skin microbiome species DOI Creative Commons
Jacob S. Baker, Evan Qu, Christopher P. Mancuso

et al.

Cell Host & Microbe, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Adult human facial skin microbiomes are remarkably similar at the species level, dominated by Cutibacterium acnes and Staphylococcus epidermidis, yet each person harbors a unique community of strains. Understanding how person-specific communities assemble is critical for designing microbiome-based therapies. Here, using 4,055 isolate genomes 356 metagenomes, we reconstruct on-person evolutionary history to reveal on- between-person strain dynamics. We find that multiple cells typically involved in transmission, indicating ample opportunity migration. Despite this accessibility, family members share only some their S. epidermidis dynamic, with persisting an average 2 years. C. strains more stable have higher colonization rate during transition adult microbiome, suggesting window could facilitate engraftment therapeutic These previously undetectable dynamics may influence design microbiome therapeutics motivate study effects on hosts.

Language: Английский

Citations

0