bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Abstract In the companion paper to this, we examined consequences for patterns of linkage disequilibrium “gene” model fitness, which postulates that effects recessive or partially deleterious mutations located at different sites within a gene fail complement each other. Here, examine genetic and inbreeding loads, using both analytical simulation methods, contrast it with frequently used “sites” allows allelic complementation. We show results in slightly lower load, but much smaller than model, implying standard predictions mutational contributions depression may be overestimates. Synergistic epistasis between pairs was also modeled, shown considerably reduce load models. The theoretical are discussed relation data on Drosophila melanogaster .
Language: Английский