Antibiotics in microbial communities: an ecological frame of resistance DOI Creative Commons
Andrew D. Letten, Alex R. Hall, Jonathan M. Levine

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: May 11, 2020

Abstract There is growing awareness that our ability to tackle antibiotic resistance limited by a lack of mechanistic understanding the communities in which resistant microbes are embedded. The widespread coexistence and sensitive bacteria microbial systems presents an especially frustrating paradox. Recent advances ecological theory offer powerful framework probe mechanisms regulating intra- inter-specific coexistence, but significance this body problem antimicrobial has been largely overlooked. In Perspectives article, we draw on emerging illustrate how changes both competitive niche overlap critical for costs persistence pathogens systems. We then show trade-offs resource acquisition strategies can have counter-intuitive consequences susceptible genotypes variable environments. These insights highlight numerous opportunities innovative experimental theoretical research into microbiome.

Language: Английский

Antibiotics in microbial communities: an ecological frame of resistance DOI Creative Commons
Andrew D. Letten, Alex R. Hall, Jonathan M. Levine

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: May 11, 2020

Abstract There is growing awareness that our ability to tackle antibiotic resistance limited by a lack of mechanistic understanding the communities in which resistant microbes are embedded. The widespread coexistence and sensitive bacteria microbial systems presents an especially frustrating paradox. Recent advances ecological theory offer powerful framework probe mechanisms regulating intra- inter-specific coexistence, but significance this body problem antimicrobial has been largely overlooked. In Perspectives article, we draw on emerging illustrate how changes both competitive niche overlap critical for costs persistence pathogens systems. We then show trade-offs resource acquisition strategies can have counter-intuitive consequences susceptible genotypes variable environments. These insights highlight numerous opportunities innovative experimental theoretical research into microbiome.

Language: Английский

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