Store-Operated Calcium Channels

Physiological Reviews, Journal Year: 2015, Volume and Issue: 95(4), P. 1383 - 1436

Published: Sept. 24, 2015

Store-operated calcium channels (SOCs) are a major pathway for signaling in virtually all metozoan cells and serve wide variety of functions ranging from gene expression, motility, secretion to tissue organ development the immune response. SOCs activated by depletion Ca 2+ endoplasmic reticulum (ER), triggered physiologically through stimulation diverse set surface receptors. Over 15 years after first characterization electrophysiology, identification STIM proteins as ER sensors Orai store-operated has enabled rapid progress understanding unique mechanism store-operate entry (SOCE). Depletion causes accumulate at ER-plasma membrane (PM) junctions where it traps activates diffusing closely apposed PM. Mutagenesis studies combined with recent structural insights about now beginning reveal molecular underpinnings these choreographic events. This review describes experimental advances underlying our current how is coupled activation SOCs. Particular emphasis placed on mechanisms activation, channel properties, modulation function, pharmacological inhibitors SOCE, physiology disease.

Language: Английский

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Calcium Signaling in Neuronal Development

Cold Spring Harbor Perspectives in Biology, Journal Year: 2011, Volume and Issue: 3(10), P. a004259 - a004259

Published: July 5, 2011

Sheila S. Rosenberg and Nicholas C. Spitzer Neurobiology Section, Division of Biological Sciences, Kavli Institute for Brain Mind, University California at San Diego, La Jolla, 92093 Correspondence: nspitzer{at}ucsd.edu

Language: Английский

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Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation

ACS Nano, Journal Year: 2015, Volume and Issue: 9(7), P. 7678 - 7689

Published: July 13, 2015

Tetragonal barium titanate nanoparticles (BTNPs) have been exploited as nanotransducers owing to their piezoelectric properties, in order provide indirect electrical stimulation SH-SY5Y neuron-like cells. Following application of ultrasounds cells treated with BTNPs, fluorescence imaging ion dynamics revealed that the synergic is able elicit a significant cellular response terms calcium and sodium fluxes; moreover, tests appropriate blockers demonstrated voltage-gated membrane channels are activated. The hypothesis was supported by lack presence cubic nonpiezoelectric further corroborated simple electroelastic model BTNP subjected ultrasounds, according which generated voltage compatible values required for activation voltage-sensitive channels.

Language: Английский

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A Role for Noncoding Variation in Schizophrenia

Cell Reports, Journal Year: 2014, Volume and Issue: 9(4), P. 1417 - 1429

Published: Nov. 1, 2014

Highlights•Schizophrenia SNPs are enriched for eQTLs and cis-regulatory elements•The enrichment is greater enhancers in fetal adult brain tissue•Schizophrenia risk participate long-range promoter-enhancer interactions•CACNA1C variants associated with transcriptional regulation the brainSummaryA large portion of common variant loci genetic schizophrenia reside within noncoding sequence unknown function. Here, we demonstrate promoter enhancer expression quantitative trait (eQTL). The when functional annotations derived from human used relative to peripheral tissues. Regulatory concordance analysis ranked genes genome-wide significant a potential role, based on colocalization SNP, eQTL, regulatory element sequence. We identified physical interactions noncontiguous proximal distal elements. This was verified prefrontal cortex -induced pluripotent stem cell–derived neurons L-type calcium channel (CACNA1C) locus. Our findings point link between schizophrenia-associated 3D genome architecture chromosomal loopings brain.Graphical abstract

Language: Английский

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Lysophosphatidic Acid Signaling in the Nervous System

Neuron, Journal Year: 2015, Volume and Issue: 85(4), P. 669 - 682

Published: Feb. 1, 2015

Language: Английский

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Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

Progress in Neurobiology, Journal Year: 2015, Volume and Issue: 134, P. 36 - 54

Published: Sept. 16, 2015

This review summarises genetic studies in which calcium channel genes have been connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and schizophrenia autism disorders intellectual impairment. Among many other genes, striking numbers gene superfamily implicated aetiology these diseases by various DNA analysis techniques. We will discuss how relate known monogenic associated with point mutations channels. then examine functional evidence for a causative link between or single nucleotide polymorphisms disease processes. A major challenge future be translate expanding psychiatric findings into altered physiological function, involvement wider pathology diseases, what potential that provides personalised stratified treatment options patients.

Language: Английский

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Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops

Neuron, Journal Year: 2016, Volume and Issue: 89(6), P. 1131 - 1156

Published: March 1, 2016

Language: Английский

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Spontaneous activity in developing thalamic and cortical sensory networks

Neuron, Journal Year: 2021, Volume and Issue: 109(16), P. 2519 - 2534

Published: July 21, 2021

Language: Английский

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Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(9)

Published: March 17, 2021

Poly(glycerol sebacate) (PGS) continues to attract attention for biomedical applications owing its favorable combination of properties. Conventionally polymerized by a two-step polycondensation glycerol and sebacic acid, variations synthesis parameters, reactant concentrations or specific chemical modifications, PGS materials can be obtained exhibiting wide range physicochemical, mechanical, morphological properties variety applications. has been extensively used in tissue engineering (TE) cardiovascular, nerve, cartilage, bone corneal tissues. Applications based drug delivery systems wound healing are also well documented. Research development the field continue progress, involving mainly modified structures using copolymers, hybrid, composite materials. Moreover, production self-healing electroactive introduced recently. After almost 20 years research on PGS, previous publications have outlined synthesis, modification, properties, applications, however, review paper covering most recent developments is lacking. The present thus covers comprehensively literature last five PGS-based biomaterials devices focusing advanced modifications medicine highlighting notable advances TE delivery.

Language: Английский

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Neuronal maturation and axon regeneration: unfixing circuitry to enable repair

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(10), P. 649 - 667

Published: Aug. 20, 2024

Language: Английский

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