Cold Spring Harbor Perspectives in Biology,
Journal Year:
2014,
Volume and Issue:
6(3), P. a018366 - a018366
Published: March 1, 2014
Susan
Strome1,
William
G.
Kelly2,
Sevinc
Ercan3
and
Jason
D.
Lieb4
1Department
of
Molecular,
Cell
Developmental
Biology,
University
California,
Santa
Cruz,
California
95064
2Department
Emory
University,
Atlanta,
Georgia
30322
3Department
Biology
Center
for
Genomics
Systems
New
York
York,
10003
4Department
Carolina
Genome
Sciences,
The
North
at
Chapel
Hill,
27599
Correspondence:
sstrome{at}ucsc.edu
Molecular Plant Pathology,
Journal Year:
2016,
Volume and Issue:
18(6), P. 887 - 898
Published: Oct. 17, 2016
Summary
Evidently,
epigenetics
is
at
forefront
in
explaining
the
mechanisms
underlying
success
of
human
pathogens
and
identification
pathogen‐induced
modifications
within
host
plants.
However,
there
a
lack
studies
highlighting
role
modulation
growth
pathogenicity
fungal
plant
pathogens.
In
this
review,
we
attempt
to
highlight
discuss
regulation
phytopathogens
using
Magnaporthe
oryzae
,
devastating
pathogen,
as
model
system.
With
perspective
wide
application
understanding
development,
pathogenesis
control
other
pathogens,
provide
synthesized
view
epigenetic
conducted
on
M.
date.
First,
their
impact
development
pathogenicity.
Second,
unexplored
areas
research
that
should
be
considered
near
future
construct
holistic
functioning
Importantly,
complete
can
help
target
points
combat
pathogenesis.
Journal of Fungi,
Journal Year:
2022,
Volume and Issue:
8(6), P. 565 - 565
Published: May 25, 2022
Filamentous
fungal
pathogens
have
evolved
diverse
strategies
to
infect
a
variety
of
hosts
including
plants
and
insects.
The
dynamic
infection
process
requires
rapid
fine-tuning
regulation
gene
expression
programs
in
response
the
changing
host
environment
defenses.
Therefore,
transcriptional
reprogramming
is
critical
for
development
pathogenicity.
Histone
post-translational
modification,
one
main
mechanisms
epigenetic
regulation,
has
been
shown
play
an
important
role
expressions,
involved
in,
e.g.,
development,
infection-related
morphogenesis,
environmental
stress
responses,
biosynthesis
secondary
metabolites,
This
review
highlights
recent
findings
insights
into
regulatory
histone
methylation
acetylation
pathogenicity,
as
well
their
roles
modulating
pathogenic
fungi–host
interactions.
ACS Synthetic Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Fungi,
especially
filamentous
fungi,
are
a
relatively
understudied,
biotechnologically
useful
resource
with
incredible
potential
for
commercial
applications.
These
multicellular
eukaryotic
organisms
have
long
been
exploited
their
natural
production
of
commodity
chemicals
and
proteins
such
as
enzymes
used
in
starch
processing,
detergents,
food
feed
production,
pulping
paper
making
biofuels
production.
The
ability
fungi
to
use
wide
range
feedstocks
is
another
key
advantage.
As
chassis
organisms,
can
express
cellular
machinery,
metabolic
signal
transduction
pathways
from
both
prokaryotic
origins.
Their
genomes
abound
novel
genetic
elements
processes
that
be
harnessed
biotechnology
Synthetic
biology
tools
becoming
inexpensive,
modular,
expansive
while
systems
beginning
provide
the
level
understanding
required
design
increasingly
complex
synthetic
systems.
This
review
covers
challenges
working
offers
perspective
on
approaches
needed
exploit
microbial
cell
factories.
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(3), P. 584 - 584
Published: March 4, 2025
The
spontaneous
loss
of
cellulase
productivity
industrial
T.
reesei
strains
during
production
results
in
significant
economic
losses.
This
phenomenon
was
suggested
to
be
epigenetically
regulated,
but
the
previous
findings
did
not
explain
which
epigenetic
mechanisms
occur
and
how
they
promote
strain
degeneration.
Until
now,
landscape
has
been
poorly
understood.
study
investigated
whether
DNA
methylation
are
connected,
and,
if
so,
what
that
connection
is
it
relates
In
order
determine
impact
on
degeneration,
we
induced
hypomethylation
with
hydralazine
HCL,
showed
a
reduced
non-productive
phenotype
partially
restored
productivity.
As
second
test,
conducted
global
cytosine
assay,
levels
between
0.2
1.3%
5-mC.
Importantly,
exhibited
stronger
than
productive
counterparts,
patterns
varied
depending
carbon
source.
final
carried
out
deletion
experiments
targeting
putative
methyltransferases
Dim2
Rid1,
initially
occurrence
non-producing
subpopulation,
subsequent
sub-cultivation
eliminated
shows
impacts
productivity,
an
understanding
can
help
us
develop
targeted
strategies
reduce
degeneration
improve
applications.
Cold Spring Harbor Perspectives in Biology,
Journal Year:
2014,
Volume and Issue:
6(3), P. a018366 - a018366
Published: March 1, 2014
Susan
Strome1,
William
G.
Kelly2,
Sevinc
Ercan3
and
Jason
D.
Lieb4
1Department
of
Molecular,
Cell
Developmental
Biology,
University
California,
Santa
Cruz,
California
95064
2Department
Emory
University,
Atlanta,
Georgia
30322
3Department
Biology
Center
for
Genomics
Systems
New
York
York,
10003
4Department
Carolina
Genome
Sciences,
The
North
at
Chapel
Hill,
27599
Correspondence:
sstrome{at}ucsc.edu
