The molecular hallmarks of epigenetic control

Nature Reviews Genetics, Journal Year: 2016, Volume and Issue: 17(8), P. 487 - 500

Published: June 27, 2016

Language: Английский

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Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila

Cold Spring Harbor Perspectives in Biology, Journal Year: 2013, Volume and Issue: 5(8), P. a017780 - a017780

Published: Aug. 1, 2013

Sarah C.R. Elgin1 and Gunter Reuter2 1Department of Biology, CB-1137, Washington University, St. Louis, Missouri 63130 2Institute Developmental Genetics, Martin Luther University Halle, D-06120 Germany Correspondence: selgin{at}biology.wustl.edu

Language: Английский

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Epigenetic Regulation in Plants

Cold Spring Harbor Perspectives in Biology, Journal Year: 2014, Volume and Issue: 6(12), P. a019315 - a019315

Published: Dec. 1, 2014

Craig S. Pikaard1 and Ortrun Mittelsten Scheid2 1Department of Biology, Department Molecular Cellular Biochemistry, Howard Hughes Medical Institute, Indiana University, Bloomington, 47405 2Gregor Mendel-Institute Plant Austrian Academy Sciences, 1030 Vienna, Austria Correspondence: ortrun.mittelsten_scheid{at}gmi.oeaw.ac.at

Language: Английский

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FLOR-ID: an interactive database of flowering-time gene networks inArabidopsis thaliana

Nucleic Acids Research, Journal Year: 2015, Volume and Issue: 44(D1), P. D1167 - D1171

Published: Oct. 17, 2015

Flowering is a hot topic in Plant Biology and important progress has been made Arabidopsis thaliana toward unraveling the genetic networks involved. The increasing complexity explosion of literature however require development new tools for information management update. We therefore created an evolutive interactive database flowering time genes, named FLOR-ID (Flowering-Interactive Database), which freely accessible at http://www.flor-id.org. hand-curated contains on 306 genes links to 1595 publications gathering work >4500 authors. Gene/protein functions interactions within pathways were inferred from analysis related publications, included translated into manually drawn snapshots.

Language: Английский

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Histone Variants and Epigenetics

Cold Spring Harbor Perspectives in Biology, Journal Year: 2015, Volume and Issue: 7(1), P. a019364 - a019364

Published: Jan. 1, 2015

Steven Henikoff1 and M. Mitchell Smith2 1Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024 2Department of Microbiology, University Virginia, Charlottesville, Virginia 22908 Correspondence: steveh{at}fhcrc.org

Language: Английский

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Plant Transgenerational Epigenetics

Annual Review of Genetics, Journal Year: 2016, Volume and Issue: 50(1), P. 467 - 491

Published: Oct. 12, 2016

Transgenerational epigenetics is defined in opposition to developmental and implies an absence of resetting epigenetic states between generations. Unlike mammals, plants appear be particularly prone this type inheritance. In review, we summarize our knowledge about transgenerational plants, which entails heritable changes DNA methylation. We emphasize the role transposable elements other repeat sequences creation epimutable alleles. also argue that because reprogramming methylation across generations seems limited inheritance defects results from failure reinforce rather than reset modification during sexual reproduction. compare genome-wide assessments variation its phenotypic impact natural populations those made using near-isogenic derived crosses parents with experimentally induced differences. Finally, question environment inducing briefly present theoretical models under epimutability expected selected for.

Language: Английский

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Transcriptional ‘memory’ of a stress: transient chromatin and memory (epigenetic) marks at stress‐response genes

The Plant Journal, Journal Year: 2015, Volume and Issue: 83(1), P. 149 - 159

Published: March 19, 2015

Summary Drought, salinity, extreme temperature variations, pathogen and herbivory attacks are recurring environmental stresses experienced by plants throughout their life. To survive repeated stresses, provide responses that may be different from response during the first encounter with stress. A to a similar stress represents concept of ‘stress memory’. coordinated reaction at organismal, cellular gene/genome levels is thought increase survival chances improving plant's tolerance/avoidance abilities. Ultimately, memory mechanism for acclimation adaptation. At molecular level, indicates mechanisms responsible memory‐type transcription not based on repetitive activation same pathways activated Some recent advances in search ‘memory factors’ discussed an emphasis super‐induced dehydration genes Arabidopsis.

Language: Английский

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A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing

Nucleic Acids Research, Journal Year: 2017, Volume and Issue: 45(9), P. 5061 - 5073

Published: April 5, 2017

Alternative splicing generates multiple transcript and protein isoforms from the same gene thus is important in expression regulation. To date, RNA-sequencing (RNA-seq) standard method for quantifying changes alternative on a genome-wide scale. Understanding current limitations of RNA-seq crucial reliable analysis lack high quality, comprehensive transcriptomes most species, including model organisms such as Arabidopsis, major constraint accurate quantification isoforms. address this, we designed novel pipeline with stringent filters assembled Reference Transcript Dataset Arabidopsis (AtRTD2) containing 82,190 non-redundant transcripts 34 212 genes. Extensive experimental validation showed that AtRTD2 its modified version, AtRTD2-QUASI, use Quantification Alternatively Spliced Isoforms, outperform other available analysis. This strategy can be implemented species to build transcript-level analyses.

Language: Английский

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Transcriptional Silencing by Polycomb-Group Proteins

Cold Spring Harbor Perspectives in Biology, Journal Year: 2014, Volume and Issue: 6(11), P. a019331 - a019331

Published: Nov. 1, 2014

Ueli Grossniklaus1 and Renato Paro2 1Institute of Plant Biology Zürich-Basel Science Center, University Zürich, CH-8008 Switzerland 2Department Biosystems Engineering, ETH 4058 Basel, Correspondence: grossnik{at}botinst.uzh.ch

Language: Английский

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A Role for Epigenetic Regulation in the Adaptation and Stress Responses of Non-model Plants

Frontiers in Plant Science, Journal Year: 2019, Volume and Issue: 10

Published: March 1, 2019

In recent years enormous progress has been made in understanding the role of epigenetic regulation response to environmental stimuli, especially stresses. Molecular mechanisms involved chromatin silencing and dynamics have explained, leading an appreciation how new phenotypes can be generated quickly modifications. some cases, it also shown that modifications stably transmitted next generations. Despite this, vast majority studies carried out with model plants, particularly Arabidopsis, very little is known on native plants their natural habitat react changes environment. Climate change affecting, sometimes drastically, conditions numerous ecosystems around world, forcing populations species adapt quickly. Although part adaptation explained by preexisting genetic variation populations, stable through few generations, contributing stability survival habitat. Here, we review data suggest help cope environments.

Language: Английский

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