The lipid side of unfolded protein response
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids,
Journal Year:
2024,
Volume and Issue:
1869(7), P. 159515 - 159515
Published: June 5, 2024
Although
our
current
knowledge
of
the
molecular
crosstalk
between
ER
stress,
unfolded
protein
response
(UPR),
and
lipid
homeostasis
remains
limited,
there
is
increasing
evidence
that
dysregulation
either
or
profoundly
affects
other.
Most
research
regarding
UPR
signaling
in
human
diseases
has
focused
on
causes
consequences
disrupted
folding.
The
itself
consists
very
complex
pathways
function
to
not
only
maintain
homeostasis,
but
just
as
importantly,
modulate
biogenesis
allow
adjust
promote
cell
survival.
Lipid
known
activate
many
aspects
UPR,
complexity
this
a
major
barrier.
disequilibrium
lipotoxicity
are
be
important
contributors
numerous
pathologies,
including
insulin
resistance,
liver
disease,
cardiovascular
diseases,
neurodegenerative
cancer.
Despite
their
medical
significance
continuous
research,
however,
mechanisms
synthesis
during
stress
conditions,
impact
fate
decisions,
remain
poorly
understood.
Here
we
summarize
view
connections
altered
metabolism,
UPR.
Language: Английский
Aruncus Dioicus Var. Kamtschaticus Extract Prevents Ocular Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress In Vitro
Journal of Medicinal Food,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
The
aim
of
this
study
was
to
determine
the
anti-inflammatory
and
anti-endoplasmic
reticulum
(ER)
stress
effects
Aruncus
dioicus
var.
kamtschaticus
(ADK)
extract
on
ARPE-19
cells.
Pretreatment
with
ADK
effectively
mitigated
thapsigargin
(Tg)-induced
increases
in
vascular
endothelial
growth
factor
protein
secretion
intracellular
calcium
levels.
Furthermore,
pretreatment
suppressed
ocular
ER
stress-related
expression
a
dose-dependent
manner,
inhibited
loss
tight
junctions,
interleukin-6
gene
expression.
Moreover,
significantly
prevented
lipopolysaccharide-inducible
proinflammatory
cytokine
at
transcription
level
phosphorylation
proteins
involved
mitogen-activated
kinase-nuclear
kappa-light-chain-enhancer
activated
B
cells
(NFκB)
axis
posttranslational
level.
Additionally,
enhanced
antioxidant
activity,
as
evidenced
by
increased
heme
oxygenase-1
2,2-diphenyl-1-picrylhydrazyl
radical
scavenging
ferric-reducing
power.
In
conclusion,
protected
from
stress,
inflammation,
oxidative
demonstrating
its
potential
nutraceutical
intervention
for
diseases.
Language: Английский
Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication
Jingyu Xu,
No information about this author
B Wang,
No information about this author
Haiqing Ao
No information about this author
et al.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 20, 2025
The
body
instinctively
responds
to
external
stimuli
by
increasing
energy
metabolism
and
initiating
immune
responses
upon
receiving
stress
signals.
Corticosterone
(CORT),
a
glucocorticoid
(GC)
that
regulates
secretion
along
the
hypothalamic-pituitary-adrenal
(HPA)
axis,
mediates
neurotransmission
humoral
regulation.
Due
widespread
expression
of
receptors
(GR),
effects
CORT
are
almost
ubiquitous
in
various
tissue
cells.
Therefore,
on
one
hand,
is
molecular
signal
activates
body’s
system
during
other
due
chemical
properties
GCs,
anti-inflammatory
act
as
stabilizers
control
response
stress.
Inflammation
manifestation
activation.
plays
dual
roles
this
process
both
promoting
inflammation
exerting
As
hormone,
levels
fluctuate
with
degree
duration
stress,
determining
its
changes
it
induces.
essential
for
resist
diseases
maintain
homeostasis,
imbalance
being
key
factor
development
diseases.
understanding
role
mechanisms
action
immunity
crucial.
This
review
addresses
important
issue
summarizes
interactions
between
system.
Language: Английский
Natural compound Alternol actives multiple endoplasmic reticulum stress-responding pathways contributing to cell death
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 20, 2024
Background:
Alternol
is
a
small
molecular
compound
isolated
from
the
fermentation
of
mutant
fungus
obtained
Taxus
brevifolia
bark.
Our
previous
studies
showed
that
treatment
induced
reactive
oxygen
species
(ROS)-dependent
immunogenic
cell
death.
This
study
conducted
comprehensive
investigation
to
explore
mechanisms
involved
in
Alternol-induced
Methods:
Prostate
cancer
PC-3,
C4-2,
and
22RV1
were
used
this
study.
interaction
with
heat
shock
proteins
(HSP)
was
determined
using
CETSA
assay.
Alternol-regulated
ER
stress
assessed
Western
blot
Extracellular
adenosine
triphosphate
(ATP)
measured
ATPlite
Luminescence
Assay
System.
Results:
results
interacted
multiple
cellular
chaperone
increased
their
expression
levels,
including
endoplasmic
reticulum
(ER)
hypoxia
up-regulated
1
(HYOU1)
protein
90
alpha
family
class
B
member
(HSP90AB1),
as
well
cytosolic
A
8
(HSPA8).
These
data
represented
potential
cause
unfolded
response
(UPR)
after
treatment.
Further
revealed
triggered
ROS-dependent
responses
via
R-like
kinase
(PERK),
inositol-requiring
enzyme
1α
(IRE1α).
The
double-stranded
RNA-dependent
(PKR)
but
not
activating
transcription
factor
6
(ATF6)
cascades,
leading
ATF-3/ATF-4
activation,
C/EBP-homologous
(CHOP)
overexpression,
X-box
binding
XBP1
splicing
induction.
In
addition,
inhibition
these
cascades
blunted
extracellular
release,
one
classical
hallmarks
Conclusion:
Taken
together,
our
demonstrate
Language: Английский