The Hippo-YAP signaling pathway and contact inhibition of growth DOI Open Access
Barry M. Gumbiner,

Nam‐Gyun Kim

Journal of Cell Science, Journal Year: 2014, Volume and Issue: 127(4), P. 709 - 717

Published: Feb. 14, 2014

ABSTRACT The Hippo-YAP pathway mediates the control of cell proliferation by contact inhibition as well other attributes physical state cells in tissues. Several mechanisms sense spatial and organization cells, function through distinct upstream modules to stimulate signaling: adherens junction or cadherin–catenin complexes, epithelial polarity tight FAT-Dachsous morphogen pathway, shape, actomyosin mechanotransduction. Soluble extracellular factors also regulate Hippo signaling, often inhibiting its activity. Indeed, a reciprocal relationship between mitogenic signaling. As result, at edges colony, wound tissue tumor are more sensitive ambient levels growth likely proliferate, migrate differentiate YAP and/or TAZ-dependent process. Thus, senses responds tissues coordinates these cues with classic growth-factor-mediated signaling pathways. This Commentary is focused on biological significance how regulatory interact produce outcomes.

Language: Английский

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation DOI Creative Commons
Neil J. Ganem,

Hauke Cornils,

Shang-Yi Chiu

et al.

Cell, Journal Year: 2014, Volume and Issue: 158(4), P. 833 - 848

Published: Aug. 1, 2014

Language: Английский

Citations

349
The Hippo signalling pathway and its implications in human health and diseases DOI Creative Commons

Minyang Fu,

Yuan Hu,

Tianxia Lan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Nov. 8, 2022

Abstract As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in regulation of numerous biological processes. Thus, substantial efforts have been made to understand upstream signals that influence activity pathway, as well its physiological functions, such cell proliferation and differentiation, organ growth, embryogenesis, tissue regeneration/wound healing. However, dysregulation can cause variety diseases, including cancer, eye cardiac pulmonary renal hepatic immune dysfunction. Therefore, therapeutic strategies target dysregulated components might be promising approaches for treatment wide spectrum diseases. Here, we review key critical functions controlled by pathway. Additionally, diseases associated with alterations potential therapies targeting will discussed.

Language: Английский

Citations

347
Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex DOI Creative Commons

Cordelia Rauskolb,

Shuguo Sun,

Gongping Sun

et al.

Cell, Journal Year: 2014, Volume and Issue: 158(1), P. 143 - 156

Published: July 1, 2014

Language: Английский

Citations

337
The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration DOI
Jun Wang, Shijie Liu, Todd R. Heallen

et al.

Nature Reviews Cardiology, Journal Year: 2018, Volume and Issue: 15(11), P. 672 - 684

Published: Aug. 15, 2018

Language: Английский

Citations

336
The Hippo-YAP signaling pathway and contact inhibition of growth DOI Open Access
Barry M. Gumbiner,

Nam‐Gyun Kim

Journal of Cell Science, Journal Year: 2014, Volume and Issue: 127(4), P. 709 - 717

Published: Feb. 14, 2014

ABSTRACT The Hippo-YAP pathway mediates the control of cell proliferation by contact inhibition as well other attributes physical state cells in tissues. Several mechanisms sense spatial and organization cells, function through distinct upstream modules to stimulate signaling: adherens junction or cadherin–catenin complexes, epithelial polarity tight FAT-Dachsous morphogen pathway, shape, actomyosin mechanotransduction. Soluble extracellular factors also regulate Hippo signaling, often inhibiting its activity. Indeed, a reciprocal relationship between mitogenic signaling. As result, at edges colony, wound tissue tumor are more sensitive ambient levels growth likely proliferate, migrate differentiate YAP and/or TAZ-dependent process. Thus, senses responds tissues coordinates these cues with classic growth-factor-mediated signaling pathways. This Commentary is focused on biological significance how regulatory interact produce outcomes.

Language: Английский

Citations

325