Coordination of nephrogenesis with branching of the urinary collecting system, the vasculature and the nervous system DOI
Dagmar Iber, Malte Mederacke, Roman Vetter

et al.

Current topics in developmental biology/Current Topics in Developmental Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

A single-cell molecular map of mouse gastrulation and early organogenesis DOI
Blanca Pijuan-Sala, Jonathan A. Griffiths, Carolina Guibentif

et al.

Nature, Journal Year: 2019, Volume and Issue: 566(7745), P. 490 - 495

Published: Feb. 1, 2019

Language: Английский

Citations

896
High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue DOI Creative Commons
Yang Liu, Mingyu Yang, Yanxiang Deng

et al.

Cell, Journal Year: 2020, Volume and Issue: 183(6), P. 1665 - 1681.e18

Published: Nov. 13, 2020

Language: Английский

Citations

678
Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids DOI
Leonardo Beccari, Naomi Moris, Mehmet Girgin

et al.

Nature, Journal Year: 2018, Volume and Issue: 562(7726), P. 272 - 276

Published: Oct. 1, 2018

Language: Английский

Citations

445
Self-Organizing 3D Human Trunk Neuromuscular Organoids DOI Creative Commons

Jorge-Miguel Faustino Martins,

Cornelius Fischer,

Alessia Urzi

et al.

Cell stem cell, Journal Year: 2020, Volume and Issue: 26(2), P. 172 - 186.e6

Published: Jan. 16, 2020

Language: Английский

Citations

263
Hox genes in development and beyond DOI Open Access
Katharine A. Hubert, Deneen M. Wellik

Development, Journal Year: 2023, Volume and Issue: 150(1)

Published: Jan. 1, 2023

ABSTRACT Hox genes encode evolutionarily conserved transcription factors that are essential for the proper development of bilaterian organisms. unique because they spatially and temporally regulated during in a manner is dictated by their tightly linked genomic organization. Although genetic function embryonic has been interrogated, less known about how these regulate downstream to direct morphogenetic events. Moreover, continued expression at postnatal adult stages highlights crucial roles throughout life an organism. Here, we provide overview genes, highlighting evolutionary history, organization this impacts regulation expression, what protein structure, deployment beyond.

Language: Английский

Citations

55
What does time mean in development? DOI Creative Commons
Miki Ebisuya, James Briscoe

Development, Journal Year: 2018, Volume and Issue: 145(12)

Published: June 15, 2018

ABSTRACT Biology is dynamic. Timescales range from frenetic sub-second ion fluxes and enzymatic reactions to the glacial millions of years evolutionary change. Falling somewhere in middle this are processes we usually study development: cell division differentiation, gene expression, cell-cell signalling, morphogenesis. But what sets tempo manages order developmental events? Are different between species? How sequence multiple events coordinated? Here, discuss importance time for developing embryos, highlighting necessity global as well cell-autonomous control. New reagents tools imaging genomic engineering, combined with vitro culture, beginning offer fresh perspectives molecular insight into origin mechanisms time.

Language: Английский

Citations

140
Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes DOI Creative Commons
Rita Aires,

Luísa de Lemos,

Ana Nóvoa

et al.

Developmental Cell, Journal Year: 2019, Volume and Issue: 48(3), P. 383 - 395.e8

Published: Jan. 17, 2019

Language: Английский

Citations

111
Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering DOI Creative Commons
Alfonso Martínez Arias, Yusuke Marikawa, Naomi Moris

et al.

Developmental Biology, Journal Year: 2022, Volume and Issue: 488, P. 35 - 46

Published: May 7, 2022

Language: Английский

Citations

47
Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis DOI
Simona Gribaudo,

Rémi Robert,

Björn van Sambeek

et al.

Nature Biotechnology, Journal Year: 2023, Volume and Issue: 42(8), P. 1243 - 1253

Published: Sept. 14, 2023

Language: Английский

Citations

42
Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos DOI Creative Commons
Hocine Rekaik, Lucille Lopez‐Delisle, Aurélie Hintermann

et al.

Nature Genetics, Journal Year: 2023, Volume and Issue: 55(7), P. 1164 - 1175

Published: June 15, 2023

During development, Hox genes are temporally activated according to their relative positions on clusters, contributing the proper identities of structures along rostrocaudal axis. To understand mechanism underlying this timer, we used mouse embryonic stem cell-derived stembryos. Following Wnt signaling, process involves transcriptional initiation at anterior part cluster and a concomitant loading cohesin complexes enriched transcribed DNA segments, that is, with an asymmetric distribution favoring cluster. Chromatin extrusion then occurs successively more posterior CTCF sites acting as transient insulators, thus generating progressive time delay in activation posterior-located due long-range contacts flanking topologically associating domain. Mutant stembryos support model reveal presence evolutionary conserved regularly spaced intergenic controls precision pace temporal mechanism.

Language: Английский

Citations

28