Developmental neurotoxic effects of two pesticides: Behavior and neuroprotein studies on endosulfan and cypermethrin

Toxicology, Journal Year: 2015, Volume and Issue: 335, P. 1 - 10

Published: July 4, 2015

Language: Английский

---

Calcium/Calmodulin-Dependent Protein Kinase II and Eukaryotic Elongation Factor 2 Kinase Pathways Mediate the Antidepressant Action of Ketamine

Biological Psychiatry, Journal Year: 2017, Volume and Issue: 84(1), P. 65 - 75

Published: Dec. 6, 2017

Language: Английский

---

PKA-CREB-BDNF signaling pathway mediates propofol-induced long-term learning and memory impairment in hippocampus of rats

Brain Research, Journal Year: 2018, Volume and Issue: 1691, P. 64 - 74

Published: April 21, 2018

Language: Английский

---

Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N -methyl- d -aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children

Toxicology and Applied Pharmacology, Journal Year: 2018, Volume and Issue: 354, P. 153 - 175

Published: March 8, 2018

The Adverse Outcome Pathways (AOPs) are designed to provide mechanistic understanding of complex biological systems and pathways toxicity that result in adverse outcomes (AOs) relevant regulatory endpoints. AOP concept captures a structured way the causal relationships resulting from initial chemical interaction with target(s) (molecular initiating event) an AO manifested individual organisms and/or populations through sequential series key events (KEs), which cellular, anatomical functional changes processes. An provides detail required support safety assessment, development alternative methods implementation integrated testing strategy. example developmental neurotoxicity (DNT) is described here following requirements information defined by OECD Users' Handbook Supplement Guidance Document for developing assessing AOPs. In this AOP, binding antagonist glutamate receptor N-methyl-d-aspartate (NMDAR) as MIE. This MIE triggers cascade cellular KEs including reduction intracellular calcium levels, brain derived neurotrophic factor release, neuronal cell death, decreased presynaptic release aberrant dendritic morphology. At organ level, above mentioned lead synaptogenesis network formation function causing learning memory deficit at organism AO. There vitro, vivo epidemiological data their causative rendering DNT evaluation context purposes.

Language: Английский

---

Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics

Cell, Journal Year: 2020, Volume and Issue: 183(6), P. 1682 - 1698.e24

Published: Nov. 23, 2020

Language: Английский

---