A stepwise emergence of evolution in the RNA world DOI Creative Commons
Philippe Nghe

FEBS Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Building on experimental evidence and replicator theories, I propose a 3‐stage scenario for transition from autocatalysis into template‐based replication of RNA, providing pathway the origin life. In stage 1, self‐reproduction occurs via using oligomer substrates, viability relies substrate‐specificity, heritable variations are mediated by structural interactions. 2, coexists with templated ligation external substrates. This dual mode reproduction combined limited diffusion avoids error catastrophe. 3, takes over uses substrates decreasing size, made possible enhanced catalytic properties compartmentalization. Structural complexity, efficiency, metabolic cellularization all evolve gradually interdependently, ultimately leading to evolutionary processes similar extant biology. Impact statement perspective proposes testable stepwise emergence evolution in an RNA It shows how could appear gradual manner, thanks feedback among random mixtures molecules. highlights couplings between different facets molecular self‐organization, which bootstrap

Language: Английский

Protocell Dynamics: Modelling Growth and Division of Lipid Vesicles Driven by an Autocatalytic Reaction DOI Creative Commons

Japraj Taneja,

Paul G. Higgs

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 724 - 724

Published: April 29, 2025

We study a computational model of protocell, in which an autocatalytic reaction sustains itself inside lipid vesicle. The drives volume growth via osmosis. Membrane area grows due to addition lipids from the environment. membrane rate depends on external concentration and tension membrane. In absence division, cell either reaches state homeostasis or point where internal collapses. If becomes elongated, it can divide into two smaller spherical vesicles, conserving total area. determine when is energetically favorable for large vesicle divide. Division requires buildup difference between areas outer inner leaflets occurs most easily flipping relatively slow. too fast, parent without dividing. There typical size at division occurs, producing daughter cells unequal sizes. larger daughters regrow same before next division. Protocells with active metabolism reach stable are well balanced. Active protocells grow conditions inactive cannot.

Language: Английский

Citations

0
A stepwise emergence of evolution in the RNA world DOI Creative Commons
Philippe Nghe

FEBS Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Building on experimental evidence and replicator theories, I propose a 3‐stage scenario for transition from autocatalysis into template‐based replication of RNA, providing pathway the origin life. In stage 1, self‐reproduction occurs via using oligomer substrates, viability relies substrate‐specificity, heritable variations are mediated by structural interactions. 2, coexists with templated ligation external substrates. This dual mode reproduction combined limited diffusion avoids error catastrophe. 3, takes over uses substrates decreasing size, made possible enhanced catalytic properties compartmentalization. Structural complexity, efficiency, metabolic cellularization all evolve gradually interdependently, ultimately leading to evolutionary processes similar extant biology. Impact statement perspective proposes testable stepwise emergence evolution in an RNA It shows how could appear gradual manner, thanks feedback among random mixtures molecules. highlights couplings between different facets molecular self‐organization, which bootstrap

Language: Английский

Citations

0