Flocking and giant fluctuations in epithelial active solids DOI Creative Commons
Yuan Shen, Jérémy O’Byrne, Andreas Schoenit

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(16)

Published: April 18, 2025

The collective motion of epithelial cells is a fundamental biological process which plays significant role in embryogenesis, wound healing, and tumor metastasis. While it has been broadly investigated for over decade both vivo vitro, large-scale coherent flocking phases remain underexplored have so far mostly described as fluid. In this work, we report an additional mode different cell types vitro with distinctive features. By tracking individual cells, show that move long time scales coherently not fluid, but polar elastic solid negligible rearrangements. Our analysis reveals phase exhibits signatures long-range order, accompanying scale-free correlations the transverse component velocity fluctuations, anomalously large density shear waves. Based on general theory active solids, argue these features result from massless orientational Goldstone mode, which, contrast to fluids where they are generic, require decoupling global rotations polarity in-plane deformations solids. We theoretically consistently observe experiments fluctuations diverge system sizes such phases, leading eventually rupture thus potentially loss tissue integrity at scales.

Language: Английский

Flocking and giant fluctuations in epithelial active solids DOI Creative Commons
Yuan Shen, Jérémy O’Byrne, Andreas Schoenit

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(16)

Published: April 18, 2025

The collective motion of epithelial cells is a fundamental biological process which plays significant role in embryogenesis, wound healing, and tumor metastasis. While it has been broadly investigated for over decade both vivo vitro, large-scale coherent flocking phases remain underexplored have so far mostly described as fluid. In this work, we report an additional mode different cell types vitro with distinctive features. By tracking individual cells, show that move long time scales coherently not fluid, but polar elastic solid negligible rearrangements. Our analysis reveals phase exhibits signatures long-range order, accompanying scale-free correlations the transverse component velocity fluctuations, anomalously large density shear waves. Based on general theory active solids, argue these features result from massless orientational Goldstone mode, which, contrast to fluids where they are generic, require decoupling global rotations polarity in-plane deformations solids. We theoretically consistently observe experiments fluctuations diverge system sizes such phases, leading eventually rupture thus potentially loss tissue integrity at scales.

Language: Английский

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