A framework for quantifying the coupling between brain connectivity and heartbeat dynamics: Insights into the disrupted network physiology in Parkinson's disease

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)

Published: March 23, 2024

Parkinson's disease (PD) often shows disrupted brain connectivity and autonomic dysfunctions, progressing alongside with motor cognitive decline. Recently, PD has been linked to a reduced sensitivity cardiac inputs, that is, interoception. Altogether, those signs suggest causes an altered brain-heart connection whose mechanisms remain unclear. Our study aimed explore the large-scale network disruptions neurophysiology of interoceptive in PD. We focused on examining alterations coupling their potential symptoms. developed proof-of-concept method quantify relationships between co-fluctuations sympathetic parasympathetic activities. quantified couplings from electroencephalogram electrocardiogram recordings patients off dopaminergic medication, as well healthy individuals at rest. results show fluctuating alpha gamma dynamics are patients, compared individuals. Furthermore, we under dopamine medication recover part coupling, proportion proposal offers promising approach unveil physiopathology promoting development new evaluation methods for early stages disease.

Language: Английский

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Effects of transcutaneous auricular vagus nerve stimulation (taVNS) on motor planning: a multimodal signal study

Cognitive Neurodynamics, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 24, 2025

Language: Английский

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Investigating the cortical effect of false positive feedback on motor learning in motor imagery based rehabilitative BCI training

Journal of NeuroEngineering and Rehabilitation, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 18, 2025

Abstract Background Motor imagery-based brain–computer interface (MI-BCI) is a promising solution for neurorehabilitation. Many studies proposed that reducing false positive (FP) feedback crucial inducing neural plasticity by BCI technology. However, the effect of FP on cortical induction during MI-BCI training yet to be investigated. Objective This study aims validate hypothesis affects user’s MI first comparing two different asynchronous paradigms (with and without feedback), then its effectiveness with conventional motor learning methods (passive active training). Methods Twelve healthy volunteers four patients stroke participated in study. We implemented electroencephalogram-driven systems conditions. The was provided hand exoskeleton robot performing open/close task. assessed hemodynamic responses conditions compared them using functional near-infrared spectroscopy an event-related design. effects were analyzed paradigms, as well same paradigm via statistical analysis. Results induced higher activation MI, focusing contralateral area, feedback. Additionally, within providing feedback, task period immediately following elicited lower response channel located over area ( p = 0.021 people; 0.079 people stroke). In contrast, trials where there no just before showed response, similar 0.099 people, 0.084 Conclusions reduced users training, suggesting potential negative plasticity. Therefore, minimizing may enhance rehabilitative promoting stronger plasticity, particularly area.

Language: Английский

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Vagus nerve stimulation in various stages of stroke and associated functional impairments: A review

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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