medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 18, 2024
Transcranial
focused
ultrasound
(tFUS)
is
an
emerging
neuromodulation
approach
that
has
been
demonstrated
in
animals
but
difficult
to
translate
humans
because
of
acoustic
attenuation
and
scattering
the
skull.
Optimal
dose
delivery
requires
subject-specific
skull
porosity
estimates
which
traditionally
done
using
CT.
We
propose
a
deep
learning
(DL)
estimation
from
T1-weighted
MRI
images
removes
need
for
radiation-inducing
CT
scans.
2017 IEEE International Ultrasonics Symposium (IUS),
Journal Year:
2023,
Volume and Issue:
unknown, P. 1 - 3
Published: Sept. 3, 2023
Transcranial
ultrasound
(tUS)
applications
require
accurate
simulations
to
predict
intracranial
acoustic
pressure.
tUS
are
usually
performed
neglecting
shear
wave
propagation
in
the
skull
(fluid
skull)
due
its
simplicity.
Computed
tomography
(CT)
head
scans
gold
standard
extract
geometrical
and
material
properties
needed
simulations.
To
minimize
ionizing-radiation
patients,
pseudo-CT
images
obtained
from
magnetic
resonance
(MR)
imaging
by
deep
learning
(DL)
methods
an
attractive
alternative
CT.
We
built
a
U-net
based
neural
network
map
MR
CT
simulated
field
generated
0.5
MHz
transducer
focused
on
cortex,
propagating
through
fluid-
or
solid
skull.
At
normal
incidence,
maximum
error
DL-simulated
lies
below
35%
compared
CT-simulation.
However,
at
40°of
incidence
predicted
peak
transcranial
pressure
increases
up
60%
skulls
CT-simulated
The
smaller
wavelength
of
waves
is
much
more
affected
fine
inner
structure,
which
missing
images.
Thus,
our
findings
suggest
that
DL-based
not
suitable
for
predicting
fields
arbitrary
conditions
should
only
be
considered
under
strict
incidence.
SSRN Electronic Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Background:
Non-invasive
brain
stimulation
techniques
such
as
transcranial
magnetic
and
direct
current
hold
promise
for
inducing
plasticity.
However,
their
limited
precision
may
hamper
certain
applications.
In
contrast,
Transcranial
Ultrasound
Stimulation
(TUS),
known
its
deep
targeting
capabilities,
requires
further
investigation
to
establish
efficacy
in
producing
enduring
effects
treating
neurological
psychiatric
disorders.Objective:
To
investigate
the
of
different
pulse
repetition
frequencies
(PRF)
TUS
on
motor
corticospinal
excitability.Methods:
T1-,
T2-weighted,
zero
echo
time
resonance
imaging
scans
were
acquired
from
21
neurologically
healthy
participants
neuronavigation,
skull
reconstruction,
performance
ultrasound
thermal
modelling.
The
three
PRFs
(10,
100,
1000
Hz)
with
a
constant
duty
cycle
10%
excitability
primary
cortex
assessed
using
TMS-induced
evoked
potentials
(MEPs).
Each
PRF
sham
condition
was
evaluated
separate
days,
measurements
taken
5-,
30-,
60-minutes
post-TUS.Results:
A
significant
decrease
MEP
amplitude
observed
10
Hz
(p
=
0.007),
which
persisted
at
least
30
minutes,
100
0.001),
lasting
over
60
minutes.
no
changes
found
conditions.Conclusion:
This
study
highlights
significance
selection
underscores
potential
non-invasive
approach
reduce
excitability,
offering
valuable
insights
future
clinical
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 18, 2024
Transcranial
focused
ultrasound
(tFUS)
is
an
emerging
neuromodulation
approach
that
has
been
demonstrated
in
animals
but
difficult
to
translate
humans
because
of
acoustic
attenuation
and
scattering
the
skull.
Optimal
dose
delivery
requires
subject-specific
skull
porosity
estimates
which
traditionally
done
using
CT.
We
propose
a
deep
learning
(DL)
estimation
from
T1-weighted
MRI
images
removes
need
for
radiation-inducing
CT
scans.
