Deep Eutectic Solvents for Essential-Oil Delivery and Bacterial-Infected Wound Healing DOI
Yaping Liu, Di Wang,

Yaoyao Lai

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(45), P. 23766 - 23779

Published: Oct. 31, 2024

Essential oils (EOs) are volatile secondary metabolites of natural plants with multitudinous pharmacological activities. However, limited by their properties, such as low solubility, high volatility, photothermal instability, irritation, release, etc., EOs encounter significant challenges in pharmaceutical applications. Deep eutectic solvents (DESs) have been developed for the transdermal delivery biomolecules and lipid-soluble drugs. Herein, a series DES carriers were synthesized to improve undesirable properties EOs. We first optimized DESs according solubilization aqueous dispersity using Chimonanthus nitens Oliv. EO (COEO) model EO. Then, EO–DES formulations diluted prepare optimal nanoformulations (AqEDs). Mechanically, hydrogen bonding allowed dissolve complex components EOs; meanwhile, interaction forces, π–π stacking bonding, drove assemble into nanostructures conditions, forming AqEDs. Lastly, case study demonstrated that clove EO-AqEDscould effectively promote methicillin-resistant Staphylococcus aureus-infected wound healing vivo, along biocompatibility. This AqED strategy provides generalized platform solubilizing improving transdermal/topical delivery.

Language: Английский

Electrochemical sensing of strontium ions cyclic voltammetry and investigation of rosemary extract's effects on their behavior: Antibacterial properties of rosemary extract and molecular docking analysis for potential COVID-19 therapeutic benefits DOI

Reham H. Wahba,

A.Z. El‐Sonbati, M.A. Diab

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 200, P. 110398 - 110398

Published: March 26, 2024

Language: Английский

Citations

5
Effect of Rosmarinus officinalis supplementation on productive performance and egg quality traits in laying hens: A systematic review and meta-analysis DOI Creative Commons
Hossein Hassanpour, Aziz A. Fallah,

Navid Farhadi

et al.

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101659 - 101659

Published: Jan. 1, 2025

Language: Английский

Citations

0
Antifungal Properties of Essential Oils From Rosmarinus Officinalis, Citrus Aurantium, and Origanum Majorana DOI

Chaymae El-Hajjaji,

Soukaina Msairi, Oumaima Ninich

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 309 - 326

Published: March 14, 2025

With the prohibition of many chemical pesticides due to their impact on health living resources, as well quality food, soil and water, it has become essential look for alternatives natural origin that promote sustainability. This study focuses antifungal activity Rosmarinus officinalis, Origanum majorana Citrus aurantium oils against Phytophthora palmivora Alternaria alternata. The six oil concentrations was tested in vitro by direct contact method. After a seven-day follow-up, results revealed significant effect oil, with total inhibition mycelial growth at concentration 1.5 μl/ml 3.33 alternata respectively. While officinalis showed less activity, MICs ranging from 6.66 μL/mL 12.5 μL/mL. These promising pave way vivo efficacy tests confirm its use more sustainable agricultural practices.

Language: Английский

Citations

0
Neuropharmacological mechanisms and psychotherapeutic effects of essential oils: A systematic review DOI

Gopalsamy Rajiv Gandhi,

Govindasamy Hariharan, Singamoorthy Amalraj

et al.

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 181, P. 90 - 104

Published: April 18, 2025

Language: Английский

Citations

0
Antioxidation Activity Enhancement by Intramolecular Hydrogen Bond and Non-Browning Mechanism of Active Ingredients in Rosemary: Carnosic Acid and Carnosol DOI
Xinyu Liu, Wenzhu Wang,

Song‐Po Yao

et al.

The Journal of Physical Chemistry B, Journal Year: 2024, Volume and Issue: 128(31), P. 7627 - 7638

Published: July 29, 2024

Rosemary is one of the most promising, versatile, and studied natural preservatives. Carnosic acid (CA) carnosol (CARN), as primary active ingredients rosemary extracts, have little difference in structure, but their antioxidant activities vary significantly, depending on system studied. The underlying molecular mechanisms remain unclear. By means optical spectroscopies, stopped-flow, laser photolysis, density functional theory (DFT) calculations, we compared CA CARN between reaction dynamics radical scavenging, metal ion chelation, oxidation inhibition lipid emulsion beef, well interactions with β-carotene (β-Car). For reference, 3-isopropyl catechol (IC), which structurally similar to groups CARN, was parallel. It found for that intramolecular hydrogen bond can boost acidity its phenol hydroxyl synergistic effect β-Car substantially enhance antioxidation activity model systems meat via CA-to-β-Car electron transfer reaction. substitution A B rings group both limits browning caused by formation oxidative products antioxidants.

Language: Английский

Citations

3
Nutritional Composition, Phytochemical Profile, Therapeutic Potentials, and Food Applications of Rosemary: A Comprehensive Review DOI
Amar Shankar, Abid Ali,

Hafiz Muhammad Abdullah

et al.

Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: 135, P. 106688 - 106688

Published: Aug. 28, 2024

Language: Английский

Citations

3
Sustainable management of rosemary wastewater and essential oil in agri-environmental bioprocessing DOI Creative Commons
Imane Ziani, Hamza Bouakline,

Saliha Bouknana

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105263 - 105263

Published: Oct. 10, 2024

Language: Английский

Citations

3
Optimization of Enzyme-Assisted Extraction of Rosemary Essential Oil Using Response Surface Methodology and Its Antioxidant Activity by Activating Nrf2 Signaling Pathway DOI Creative Commons
Yuanyuan Li, Lei Huang,

Yongfang Xu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(14), P. 3382 - 3382

Published: July 18, 2024

Rosemary essential oil (REO) is widely recognized as a food flavoring and traditional herb possesses potential antioxidant activity. However, its low yield rate unclarified mechanism warrant further investigation. In this study, an enzyme pretreatment-assisted extraction method with Box–Behnken design (BBD) response surface methodology (RSM) models was employed to optimize the main factors of REO, molecular under oxidative stress elucidated in hydrogen peroxide-induced human lung carcinoma (A549) cells. The optimized (4.10%) REO recorded following optimum conditions: amount 1.60%, digestion pH 5.0, temperature 46.50 °C, time 1.7 h. Meanwhile, 1.8-cineole (53.48%) β-pinene (20.23%) exhibited radical scavenging activity higher than that BHA BHT. At cellular level, (12.5–50 µg/mL) increased levels cell viability, CAT, SOD, GSH significantly while reducing contents ROS, MDA, GSSG, when compared H2O2 exposure. Mechanically, relieved via activating Nrf2 signaling pathway enhancing protein expression Nrf2, NQO-1, HO-1, which verified by docking between component Kelch domain KEAP1. Therefore, could be considered potent natural strategy pharmaceutical industries.

Language: Английский

Citations

1
Deep Eutectic Solvents for Essential-Oil Delivery and Bacterial-Infected Wound Healing DOI
Yaping Liu, Di Wang,

Yaoyao Lai

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(45), P. 23766 - 23779

Published: Oct. 31, 2024

Essential oils (EOs) are volatile secondary metabolites of natural plants with multitudinous pharmacological activities. However, limited by their properties, such as low solubility, high volatility, photothermal instability, irritation, release, etc., EOs encounter significant challenges in pharmaceutical applications. Deep eutectic solvents (DESs) have been developed for the transdermal delivery biomolecules and lipid-soluble drugs. Herein, a series DES carriers were synthesized to improve undesirable properties EOs. We first optimized DESs according solubilization aqueous dispersity using Chimonanthus nitens Oliv. EO (COEO) model EO. Then, EO–DES formulations diluted prepare optimal nanoformulations (AqEDs). Mechanically, hydrogen bonding allowed dissolve complex components EOs; meanwhile, interaction forces, π–π stacking bonding, drove assemble into nanostructures conditions, forming AqEDs. Lastly, case study demonstrated that clove EO-AqEDscould effectively promote methicillin-resistant Staphylococcus aureus-infected wound healing vivo, along biocompatibility. This AqED strategy provides generalized platform solubilizing improving transdermal/topical delivery.

Language: Английский

Citations

1