Immunonutrition in Operated-on Gastric Cancer Patients: An Update DOI Creative Commons
John K. Triantafillidis,

Konstantinos Malgarinos

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2876 - 2876

Published: Dec. 18, 2024

Enteral immune nutrition has attracted considerable attention over the past few years regarding its perioperative role in patients undergoing major surgery for digestive cancer. Today, term enteral refers to administration of nutritional preparations containing, among others, specific ingredients such as glutamine, omega-3 polyunsaturated fatty acids, and arginine. They provide support exert pharmacological effects through substances contained these preparations. Their with gastric cancer is necessary malnutrition other metabolic disorders are frequent symptoms on level responses, affecting function intestinal permeability and, therefore, effectiveness chemotherapy. Existing clinical data from all meta-analyses published so far view that enhances responses patients, reduces rate postoperative complications, duration hospitalization without, however, improving patient survival. The content nutrition, dose, interval, effect survival should be more precisely determined relevant extensive multicenter studies. This systematic review describes analyses results findings application emphasize importance this therapeutic intervention disease progression, attempts practical guidelines applying daily practice.

Language: Английский

Glutamine Peptides: Preparation, Analysis, Applications, and Their Role in Intestinal Barrier Protection DOI Open Access
Jinyu Wang, Yating He,

Z. Liu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1017 - 1017

Published: March 14, 2025

Background: Glutamine peptides refer to a series of containing glutamine, and the activity glutamine is characterized by content non-nitrogen terminal in peptide. It has been found that are stable substitute for monomer, they increasingly studied nutrition physiology due their functional properties. Methods: An extensive search literature was conducted PubMed, Web Science, Scopus, Google Scholar databases up December 2024. Inclusion criteria focused on role intestinal health, included screened summarized. Results: This study systematically reviews current status research preparation, analysis, applications barrier protection. Furthermore, challenges faced development direction future discussed. Conclusions: can play protecting regulating tight junctions, mucin, inflammatory response, flora. In addition, further intensive investigations urgently required address pertaining structure–activity relationships transport absorption mechanism gut. review contributes better understanding protect function also provides reference foods with protective effects function.

Language: Английский

Citations

0
Current research and future prospects of immunonutrition in gastrointestinal malignancies DOI Creative Commons
Xiaoyan Ma,

Beibei Pei,

Na Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 6, 2024

Immune nutrition, as an integral component of nutritional support therapy, has garnered significant attention and research in the treatment gastrointestinal malignancies. Recent advancements formulas containing components such glutamine, omega-3 polyunsaturated fatty acids, arginine have led to development what is now termed immune nutrition or pharmacological nutrition. These formulations go beyond traditional support, functioning more like supplements with effects. Patients malignancies often experience malnutrition metabolic disturbances, resulting dysfunction, cytokine dysregulation, endocrine abnormalities. issues can compromise intestinal mucosal barrier function, affecting efficacy prognosis anticancer therapies. studies indicate that modulate specific mechanisms involved various inflammatory pathways, thereby improving patients' status outcomes. While optimal patient selection, dosing, timing are still under investigation, its potential applications oncology promising. This article aims analyze existing evidence regarding therapeutic benefits malignancies, offering insights into clinical standardization application.

Language: Английский

Citations

1
Immunonutrition in Operated-on Gastric Cancer Patients: An Update DOI Creative Commons
John K. Triantafillidis,

Konstantinos Malgarinos

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2876 - 2876

Published: Dec. 18, 2024

Enteral immune nutrition has attracted considerable attention over the past few years regarding its perioperative role in patients undergoing major surgery for digestive cancer. Today, term enteral refers to administration of nutritional preparations containing, among others, specific ingredients such as glutamine, omega-3 polyunsaturated fatty acids, and arginine. They provide support exert pharmacological effects through substances contained these preparations. Their with gastric cancer is necessary malnutrition other metabolic disorders are frequent symptoms on level responses, affecting function intestinal permeability and, therefore, effectiveness chemotherapy. Existing clinical data from all meta-analyses published so far view that enhances responses patients, reduces rate postoperative complications, duration hospitalization without, however, improving patient survival. The content nutrition, dose, interval, effect survival should be more precisely determined relevant extensive multicenter studies. This systematic review describes analyses results findings application emphasize importance this therapeutic intervention disease progression, attempts practical guidelines applying daily practice.

Language: Английский

Citations

0