Exploration of Bioactive Umami Peptides from Wheat Gluten: Umami Mechanism, Antioxidant Activity, and Potential Disease Target Sites DOI Creative Commons

Haowen Chen,

Huiyan Zhao,

Cuiling Li

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3805 - 3805

Published: Nov. 26, 2024

Umami peptides have the ability to enhance food flavours and potential health benefits. The objective of this study was conduct a comprehensive investigation into umami intensity, taste mechanism, antioxidant activity six derived from wheat gluten hydrolysates (WGHs) fermented WGHs. e-tongue analysis demonstrated that exhibited direct proportionality in terms value concentration, were capable enhancing commercially available condiments. molecular dynamics simulations interacted with T1R1/T1R3 receptors via hydrogen bonds, hydrophobic interactions, ionic water bridges, thereby producing umami. Furthermore, DPPH, ABTS, hydroxyl radical-scavenging, FRAP assays vitro. Ultimately, network pharmacology docking results indicated AKT1, JUN, CASP3 may serve as core targets for treatment oxidative diseases. In conclusion, work offers novel insights use bioactive peptides, emphasising their prospective applications supplement industries.

Language: Английский

Integrative Analysis of the Fermentation Mechanisms, Antioxidant Properties, and Potential Health Benefits of Mulberry Wine Using Multiple Bioinformatics Approaches DOI

Chaohong He,

Johane Johari Mkunga,

Dongsheng Zhang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106185 - 106185

Published: Feb. 1, 2025

Language: Английский

Citations

1
Integrative analyzing the molecular basis of Clerodendranthus Spicatus aqueous extract in hyperuricemia nephropathy via network pharmacology and experimental validation DOI
Chuang Li,

Danyao Lin,

Jianting Ouyang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106152 - 106152

Published: Feb. 1, 2025

Language: Английский

Citations

0
Comprehensive lipidomics and flavoromics reveals the accelerated oxidation mechanism of fish oil from silver carp (Hypophthalmichthys molitrix) viscera during heating DOI
Jinlin Li, Bai Jian,

Yuan Liping

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 478, P. 143651 - 143651

Published: March 4, 2025

Language: Английский

Citations

0
Spatial distribution of alkaloids in Fritillaria Bulbus using UPLC-Q-Exactive Orbitrap MS/MS and desorption electrospray MS imaging DOI Creative Commons

Xichuang Guo,

Keyun Cheng, Chenxin Wang

et al.

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117544 - 117544

Published: Feb. 1, 2025

Language: Английский

Citations

0
Molecular Mechanisms of Dietary Bioactive Peptides in Treating Alzheimer’s Disease and Mild Cognitive Impairment by Network Pharmacology and Molecular Docking Analysis DOI
Ruirui Li, Jing Zi, Y. Hu

et al.

Rejuvenation Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Emerging evidence suggests that bioactive peptides from various foods have therapeutic potentials in improving cognitive function Alzheimer's disease (AD) and mild impairment (MCI). We aimed to explore the characteristics of these their mechanisms on AD/MCI using a network pharmacology approach. compiled dataset cognition-enhancing literatures identified shared targets between Swiss Target Predication, PharmMapper, OMIM, GeneCards, TTD, Drugbank databases. then performed functional enrichment analysis constructed gene–gene interaction identify key hub targets. Additionally, we investigated transcription factors (TFs) microRNAs (miRNAs) regulating genes. Molecular docking dynamic simulations were AutoDock Vina GROMACS. 59 oligopeptides, typically short rich arginine. These predicted interact with 222 potential relevant AD/MCI, pathways mainly involving neuroactive ligand-receptor interactions inflammation. 15 targets, regulated by 144 TFs 95 miRNAs. Notably, containing "Trp-Tyr" sequence demonstrated strong binding affinities many especially matrix metalloproteinase-9. The findings provided valuable insights into molecular through which may act against highlight for future exploration natural foods.

Language: Английский

Citations

0
Robust DEEP heterogeneous ensemble and META-learning for honey authentication DOI

Lucas Almir Cavalcante Minho,

Jaquelide de Lima Conceição,

Orlando Maia Barboza

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144001 - 144001

Published: March 1, 2025

Language: Английский

Citations

0
Mechanisms of deodorizing rapeseed oil with ethanol steam at a low temperature: A focus on free fatty acids, tocopherols, and Phytosterols DOI
Yu Gao, Yiyang Dong, Fei Liu

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 143957 - 143957

Published: March 1, 2025

Language: Английский

Citations

0
Exploring the lipid oxidation mechanisms of Antarctic krill oil (Euphausia superba) during storage based on relationship between lipidomics and volatilomics DOI
Mengna Zhang, Xuejiao Xu, Pu Chen

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144227 - 144227

Published: April 1, 2025

Language: Английский

Citations

0
Exploration of Bioactive Umami Peptides from Wheat Gluten: Umami Mechanism, Antioxidant Activity, and Potential Disease Target Sites DOI Creative Commons

Haowen Chen,

Huiyan Zhao,

Cuiling Li

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3805 - 3805

Published: Nov. 26, 2024

Umami peptides have the ability to enhance food flavours and potential health benefits. The objective of this study was conduct a comprehensive investigation into umami intensity, taste mechanism, antioxidant activity six derived from wheat gluten hydrolysates (WGHs) fermented WGHs. e-tongue analysis demonstrated that exhibited direct proportionality in terms value concentration, were capable enhancing commercially available condiments. molecular dynamics simulations interacted with T1R1/T1R3 receptors via hydrogen bonds, hydrophobic interactions, ionic water bridges, thereby producing umami. Furthermore, DPPH, ABTS, hydroxyl radical-scavenging, FRAP assays vitro. Ultimately, network pharmacology docking results indicated AKT1, JUN, CASP3 may serve as core targets for treatment oxidative diseases. In conclusion, work offers novel insights use bioactive peptides, emphasising their prospective applications supplement industries.

Language: Английский

Citations

0