Tropical Journal of Pharmaceutical Research,
Journal Year:
2023,
Volume and Issue:
22(9), P. 1849 - 1855
Published: Oct. 8, 2023
Purpose:
To
determine
the
effect
of
activating
blood
circulation
and
removing
stasis
on
recurrence
alcoholic
acute
pancreatitis
(AAP),
its
possible
mechanism.Methods:
Sixty
healthy
rats
were
selected
assigned
to
control,
model
treatment
groups
(n
=20/group).
Treatment
group
was
given
Taohong
Siwu
decoction,
while
control
abdominal
injection
0.9
%
normal
saline.
Serum
levels
amylase,
pancreatic
histopathological
score,
col
Ⅰ
content,
mRNA
expression
TGF-β
1,
TβRII,
Smad3,
as
well
sPLA2
activity,
determined.Results:
score
content
significantly
reduced
in
group,
relative
expressions
TGF-
β
TβRII
Smad3
at
each
time
point
lower
than
those
(p
<
0.05).
PLA2
activity
-
π
a
0.05).Conclusion:
Activation
removal
prevents
relapse
AAP
through
regulation
TGF-β1/TβRII/Smad3
signaling
pathway.
Cohort
studies
humans
would
be
required
confirm
application
decoction
prevent
AAP.
Pest Management Science,
Journal Year:
2024,
Volume and Issue:
80(10), P. 5233 - 5243
Published: June 20, 2024
The
range
of
Glires
is
influenced
by
human
activities
and
climate
change.
However,
the
extent
to
which
environmental
changes
have
contributed
this
relationship
remains
unclear.
We
examined
alterations
in
distribution
driving
factors
Himalayan
marmot,
plateau
pika,
zokor
on
Qinghai-Tibet
Plateau
(QTP)
using
maximum
entropy
(MaxEnt)
model
a
geographical
detector
(Geodetector).
Biological Journal of the Linnean Society,
Journal Year:
2025,
Volume and Issue:
145(1)
Published: May 1, 2025
Abstract
This
study
investigated
the
impact
of
altitude
on
gut
microbiota
composition
and
diversity
in
Eurasian
tree
sparrows
(Passer
montanus),
comparing
39
from
a
high-altitude
site
(3400
m)
43
low-altitude
(30
m).
Adult
male
similar
body
mass
were
selected,
high-throughput
sequencing
16S
rRNA
gene
was
used
to
analyse
20
faecal
samples.
The
results
showed
that
had
larger
wing
length.
at
low
is
significantly
higher
than
populations.
Low-altitude
dominated
by
Firmicutes
(46.88
±
21.85%),
while
predominance
Proteobacteria
(83.11
16.37%).
Significant
differences
microbial
community
structure
confirmed
both
alpha
beta
analyses.
Functional
predictions
suggested
enhanced
nutrient
synthesis
capabilities
sparrows,
with
relative
abundance
biosynthesis-related
pathways.
Additionally,
prevalence
potentially
pathogenic
bacteria
such
as
Staphylococcus.
Linear
discriminant
analysis
effect
size
identified
significant
across
multiple
taxonomic
levels,
three
genera
(Rhodococcus,
Turicibacter,
Diaphorobacter)
demonstrating
elevated
group.
These
findings
indicate
shapes
functional
potential
influencing
their
ecological
physiological
adaptations.
understanding
aids
avian
ecology
conservation
strategies
varied
altitudinal
ranges.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 26, 2023
In
recent
decades,
the
decline
of
male
sperm
quality
has
become
a
worldwide
phenomenon,
with
critical
importance
for
ability
to
conceive
naturally.
Recent
studies
suggest
that
fertility
function
is
closely
linked
gut
microbiota,
however,
cause-and-effect
association
between
microbiota
and
infertility
risk
currently
unclear.We
performed
one
two-sample
Mendelian
randomization
(MR)
study,
which
uses
summary
data
on
human
from
MiBioGen
consortium
as
factors
exposure.
FinnGen
Consortium
R8
was
used
obtain
GWAS
infertility.
To
evaluate
associations
linking
multiple
methods,
we
included
inverse
variance
weighted
(IVW),
MR-Egger,
Maximum
Likelihood
(ML)
Ratio.
The
heterogeneity
instrumental
variables
evaluated
through
Cochran's
Q,
Rucker's
leave-one-out
analysis
methods.We
found
positive
Allisonella,
Anaerotruncus,
Barnesiella,
Intestinibacter,
Lactococcus
according
MR
results.
Bacteroides
Romboutsia,
Ruminococcaceae
(NK4A2140group),
(UCG011)
play
protective
in
pathogenesis.It
are
causally
related
this
study.
subsequent
studies,
there
need
build
larger
more
comprehensive
database
infertility,
will
reveal
underlying
mechanisms
There
randomized
controlled
trials
validating
effect
associated
against
risk,
exploring
mechanisms.
Microbiology Spectrum,
Journal Year:
2023,
Volume and Issue:
11(6)
Published: Oct. 10, 2023
ABSTRACT
Differentiation
of
the
gut
microbiota
between
individuals
within
a
species
can
be
identified
by
enterotypes.
However,
whether
different
enterotypes
are
associated
with
host-related
physiological
status
and
adaptation
to
specific
habitats
is
still
poorly
understood.
In
this
study,
we
collected
308
cecal
samples
from
plateau
pikas
during
varying
seasons
altitudes.
We
three
bacterial
two
fungal
The
proportion
Rikenellaceae_RC9_gut_group
-
Prevotella
-predominated
enterotype
3
was
higher
than
that
other
in
all
samples.
Enterotype
1,
distinguished
norank
Muribaculaceae
,
mainly
detected
warm
season
at
high
altitudes,
whereas
2,
which
unclassified
Lachnospiraceae
cold
season.
Plateau
2
showed
significantly
alpha
diversity
those
while
1
displayed
2.
Functional
pathways
lipid
metabolism
were
enriched
carbohydrate
amino
acid
energy
3.
neutral
process
more
important
body
temperature
resting
metabolic
rate
Pikas
Sporormiaceae
Sporormiella
-dominated
may
engage
frequently
coprophagy.
Overall,
study
revealed
both
communities
clustered
into
enterotypes,
significant
differences
thermogenesis.
IMPORTANCE
microbiotas
small
mammals
play
an
role
host
homeostasis.
it
unknown
show
thermogenesis
characteristics.
Our
confirmed
harbored
distinct
capabilities
employed
various
strategies
against
environments.
Additionally,
also
found
display
Animals,
Journal Year:
2024,
Volume and Issue:
14(13), P. 1898 - 1898
Published: June 27, 2024
Freshwater
acidification
(FA)
has
become
a
global
environmental
problem,
posing
potential
threat
to
freshwater
ecosystems.
The
gut
microbiota
plays
crucial
role
in
the
host’s
response
and
adaptation
new
environments.
In
this
study,
we
investigated
changes
microbial
communities
Red-eared
slider
(Trachemys
scripta
elegans)
under
acidic
conditions
reveal
ecological
impacts
of
on
turtles.
results
showed
that
there
were
significant
differences
β-diversity
(p
=
0.03),
while
no
α-diversity
T.
s.
elegans
between
different
levels
(pH
5.5,
6.5,
7.5).
Both
Gut
Microbiome
Health
Index
(GMHI)
Microbial
Dysbiosis
(MDI)
exhibited
when
comparing
environments
with
pH
5.5
those
6.5
<
0.01).
A
comparative
analysis
also
revealed
substantial
Likewise,
7.5
At
phylum
level,
Firmicutes,
Fusobacteria,
Bacteroidota
formed
major
part
community,
Fusobacteria
acidity
0.03).
genus
Cetobacterium,
Turicibacter,
unclassified
Eubacteriaceae,
Anaerorhabdus_furcosa_group
reduced
interactivity
elegans.
addition,
LEfSe
functional
prediction
potentially_pathogenic
stress_tolerant
characteristics
findings
underscore
pivotal
provide
foundation
for
further
exploration
into
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1674 - 1674
Published: Aug. 14, 2024
Dietary
fiber
(DF)
is
an
important
nutrient
component
in
pig’s
diet
that
remarkably
influences
their
growth
and
slaughter
performance.
The
ability
of
pigs
to
digest
DF
depends
on
the
microbial
composition
intestinal
tract,
particularly
hindgut.
However,
studies
how
alters
performance
by
shaping
gut
metabolites
are
still
limited.
Therefore,
this
study
aimed
investigate
effects
composition,
functions,
metabolites,
ultimately
altering
host
using
Durco
×
Bamei
crossbred
supplemented
with
0%,
10%,
17%,
24%
broad
bean
silage
basic
diet.
We
found
final
weight,
average
daily
gain,
fat,
lean
meat
weight
significantly
decreased
increasing
DF.
Pigs
lowest
rate
fat
were
observed
fiber-supplemented
group.
Gut
communities
highest
alpha
diversity
formed
17%
relative
abundance
fiber-degrading
bacteria,
bile
acid,
succinate-producing
including
Prevotella
sp.,
Bacteroides
Ruminococcus
Parabacteroides
functional
pathways,
butanoate
metabolism
tricarboxylic
acid
[TCA]
cycle,
increased
high-fiber
groups.
concentrations
several
acids
groups,
whereas
succinate
long-chain
fatty
increased.
Our
results
indicate
a
may
alter
modulating
metabolite
pathways
succinate.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13743 - 13743
Published: Dec. 23, 2024
The
use
of
animal
models
is
crucial
for
advancing
translational
research
by
identifying
effective
treatment
targets
and
strategies
clinical
application
in
human
disease
[...]
