Effects and mechanisms of kidney bean peptides on uric-lowering activity in oteracil potassium-induced hyperuricemia rats DOI Creative Commons
Tian Zeng, Yongbo She, Tao Hou

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 116, P. 106172 - 106172

Published: April 26, 2024

In the present study, stability of kidney bean-derived DWYDIK (Asp-Trp-Tyr-Asp-Ile-Lys) after acid and alkali treatment in vitro simulated gastrointestinal digestion were determined. Next, uric acid-lowering activity mechanisms bean peptides (KBPs) studied vivo. We found that had certain tolerance to digestive enzymes. KBPs significantly inhibited xanthine oxidase, reduced creatinine content, improved changes glomerular morphological, cellular vacuolar degeneration inflammatory cell infiltration kidney, recovered intestinal tissue damages hyperuricemia rats (p < 0.05). Besides, also down-regulated Glucose transporter 9 Urate 1 0.05), whereas expression Organic anion excretion upregulated by DWYDIK. Overall, exert promising potentials as a safe therapeutic alternatives conventional drugs treating hyperuricemia.

Language: Английский

Quinazolinone Derivative MR2938 Protects DSS-Induced Barrier Dysfunction in Mice Through Regulating Gut Microbiota DOI Creative Commons

Ling Lv,

Mireguli Maimaitiming,

Jichen Yang

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 123 - 123

Published: Jan. 17, 2025

Background/Objectives: Ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), is characterized by colorectal immune infiltration and significant microbiota compositional changes. Gut homeostasis necessary to maintain the healthy state of humans. MR2938, quinazolin-4(3H)-one derivative derived from marine natural product penipanoid C, alleviated DSS-induced in dose-dependent manner. Herein, we aimed investigate impact MR2938 on gut dextran sodium sulfate (DSS)-induced mice elucidate role therapeutic mechanism for alleviating colitis. Methods: Acute was induced with DSS mice. Mice were administered 100 mg/kg or 50 MR2938. Cecal content also preserved liquid nitrogen subsequently analyzed following 16S RNA sequencing. Antibiotic cocktail-induced microbiome depletion performed further relationship between microbiota. The factor levels quantitative polymerase chain reaction (qPCR) enzyme-linked immunosorbent assay (ELISA). Alcian blue staining immunofluorescence used estimate intestinal barrier. Results: rRNA sequencing revealed modulation Compared model group, group associated higher abundances Entercoccus lower abundance Staphylococcus, while Lactobacillus Staphylococcus. antibiotic-mediated experiments demonstrated that primarily contributed barrier function protection, little during treatment. Conclusions: These findings suggest flora play crucial MR2938's

Language: Английский

Citations

0
Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria DOI
Caitlin Bond, Olivia J. Bednarski, Dibyadyuti Datta

et al.

Nature Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

Citations

0
Oleanolic Acid Alleviates Hyperuricemia via Gut Microbiota Control the Integrity of Gut Barrier and the Expressions of Urate Transporter in Mice DOI

Tingting Zhang,

Siyan Liu,

Shenlin Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Hyperuricemia (HUA) is a globally prevalent metabolic disorder characterized by an imbalance in uric acid (UA) production and excretion. In this study, we found that oleanolic (OA), natural pentacyclic triterpene, effectively reduced HUA associated kidney injury C57BL/6J mice. A 12-week OA treatment significantly dose-dependently UA creatinine levels serum urine while suppressing hepatic xanthine oxidase activity Mechanistic analysis revealed modulates the expression of urate transporters including ABCG2, GLUT9, URAT1 small intestine. Furthermore, restored gut microbiota imbalances, increased short-chain fatty production, enhanced expressions intestinal tight junction proteins mice, thereby improving barrier integrity Consequently, fecal transplantation (FMT) was employed to illustrate major mediating role OA's alleviation Recipient mice transplanted with feces from OA-treated exhibited lower blood urinary levels, inflammation, improved balance compared those receiving untreated (p < 0.05). Additionally, FMT normalized transporter reinforced junctions recipient These findings underscore mitigates primarily modulating microbiota, regulating expression, reinforcing integrity, offering novel insights into its preventive potential for managing related complications.

Language: Английский

Citations

0
Aggression and Justice Involvement: Does Uric Acid Play a Role? DOI Creative Commons

Alan Logan,

Pragya Mishra

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 268 - 268

Published: March 2, 2025

The search for biological markers that can be reliably linked to aggression and antisocial behavior has been central the work of criminology. One such marker, uric acid, long suspected play a causative role in promoting anger, irritability, aggression, violence. Here, this perspective article, we revisit some historical interest acid as compound relevant brain behavior, reflect these early accounts off emergent scientific research. Advances sciences, including neuropsychiatry neuromicrobiology, have allowed more sophisticated understanding potential mechanistic pathways linking with cognition behavior. updated science suggests ideas surrounding criminology had credibility. available research strongly biomarker risk, is worthy further close scrutiny. Informed by gut–brain–microbiome research, argue certain aspects early-to-mid-20th-century were prematurely abandoned. From legalome perspective, advances other gut–brain biomarkers aid shaping humane, scientifically grounded policies recognize interplay between biology environment.

Language: Английский

Citations

0
Chemical Migration, Digestive Behaviors and Effect on Gut Microbiota of PLA and PBAT Oligomers DOI

Guowei Ma,

Xiaomeng Gao, Yuting Chen

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137988 - 137988

Published: March 1, 2025

Language: Английский

Citations

0
Sodium butyrate promotes synthesis of testosterone and meiosis of hyperuricemic male mice DOI Creative Commons

Jiaojiao Qi,

Yu Sun,

Zeqing Chen

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 28, 2025

Hyperuricemia (HUA) impaires spermatogenesis. This study was carried out, aiming to determine whether butyric acid (NaB) avoids the HUA-induced decline of sperm quality HUA mice were developed through intra-peritoneal injection potassium oxalate combined with intragastric uric (UA) and by tube feeding 300 mg·kg-1·d-1NaB. The effect NaB on reproduction male determined measuring count, motility testosterone content. In addition, TM3 GC-2 cells treated a solution containing 30 mg/dl UA 1mM NaB. effects evaluated expression level genes involving in LH/cAMP/PKA signaling pathway meiosis, that encoding OPRL1 receptor protein. Results showed improved motility, synthesis, impaired spermatocyte meiosis via HUA. vitro analysis activated cells, promoted synthesis testosterone, up-regulated content pain-sensitive peptide (OPRL1) surface meiosis. also utilization ATP cells. We illustrated close relationship between spermatogenesis defects. NaB-promoted functioning testis may aid improving quality.

Language: Английский

Citations

0
Effects and mechanisms of kidney bean peptides on uric-lowering activity in oteracil potassium-induced hyperuricemia rats DOI Creative Commons
Tian Zeng, Yongbo She, Tao Hou

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 116, P. 106172 - 106172

Published: April 26, 2024

In the present study, stability of kidney bean-derived DWYDIK (Asp-Trp-Tyr-Asp-Ile-Lys) after acid and alkali treatment in vitro simulated gastrointestinal digestion were determined. Next, uric acid-lowering activity mechanisms bean peptides (KBPs) studied vivo. We found that had certain tolerance to digestive enzymes. KBPs significantly inhibited xanthine oxidase, reduced creatinine content, improved changes glomerular morphological, cellular vacuolar degeneration inflammatory cell infiltration kidney, recovered intestinal tissue damages hyperuricemia rats (p < 0.05). Besides, also down-regulated Glucose transporter 9 Urate 1 0.05), whereas expression Organic anion excretion upregulated by DWYDIK. Overall, exert promising potentials as a safe therapeutic alternatives conventional drugs treating hyperuricemia.

Language: Английский

Citations

2