Engineering Useful Microbial Species for Pharmaceutical Applications

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 599 - 599

Published: March 5, 2025

Microbial engineering has made a significant breakthrough in pharmaceutical biotechnology, greatly expanding the production of biologically active compounds, therapeutic proteins, and novel drug candidates. Recent advancements genetic engineering, synthetic biology, adaptive evolution have contributed to optimization microbial strains for applications, playing crucial role enhancing their productivity stability. The CRISPR-Cas system is widely utilized as precise genome modification tool, enabling enhancement metabolite biosynthesis activation biological pathways. Additionally, biology approaches allow targeted design microorganisms with improved metabolic efficiency potential, thereby accelerating development new products. integration artificial intelligence (AI) machine learning (ML) plays vital further advancing by predicting network interactions, optimizing bioprocesses, discovery process. However, challenges such efficient pathways, ensuring sustainable industrial-scale production, meeting international regulatory requirements remain critical barriers field. Furthermore, mitigate potential risks, it essential develop stringent biocontainment strategies implement appropriate oversight. This review comprehensively examines recent innovations analyzing key technological advancements, challenges, future perspectives.

Language: Английский

Mechanistic Study of Cancer Drug Delivery: Current Techniques, Limitations, and Future Prospects

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 290, P. 117535 - 117535

Published: March 20, 2025

Cancer drug delivery remains a critical challenge with systemic toxicity, poor bioavailability, and lack of effective targeting. Overcoming these barriers is essential for improving treatment efficacy patient outcomes. This review discusses current techniques that reshape cancer therapy by offering precise, controlled-release tailored to tumor-specific features. Innovations in nanotechnology, immunotherapy, gene enable interventions at molecular cellular levels. Radiomics pathomics integrate high-dimensional data optimize diagnostics planning. Combination addresses the complexities tumor heterogeneity synergizing multiple agents within single therapeutic framework, while peptide-drug conjugates enhance specificity potency. Hydrogel-based systems microneedle arrays offer localized, sustained release, significantly However, clinical translation advancements faces significant such as resistance, off-target effects, scalability, cost, ethical concerns. Moreover, regulatory economic feasibility therapies highlight need innovative frameworks make them accessible globally. Therefore, there innovation cell therapy, next-generation platforms, personalized medicine. focuses on recent over past decade, evaluating their limitations exploring potential future directions transforming treatment.

Language: Английский

The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 54

Published: April 5, 2025

Cancer is a leading cause of mortality and morbidity worldwide. Nanomaterials, unique optical, magnetic, electrical properties at the nanoscale (1-100 nm), have been engineered to improve drug capacity, bioavailability, specificity in cancer treatment. These advancements address toxicity lack selectivity conventional therapies, enabling precise targeting cells, tumor microenvironment, immune system. Among emerging approaches, bacterial treatment shows promise due its natural ability target diverse therapeutic mechanisms, which nanotechnology can further enhance. Bacteria-based delivery systems leverage bacteria's adaptability survival strategies within human body. Bacterial derivatives, such as ghosts (BGs), extracellular vesicles (BEVs), dietary toxins, are recognized effective biological nanomaterials capable carrying nanoparticles (NPs). attracted increasing attention for their potential targeted NP This study explores use various bacteria byproducts vehicles, highlighting treating different types cancer. By combining strengths therapy, these innovative approaches aim revolutionize with improved precision efficacy.

Language: Английский