Advancement of Computational Design Drug Delivery System in COVID- 19: Current Updates and Future Crosstalk- A Critical Update

Infectious Disorders - Drug Targets, Journal Year: 2023, Volume and Issue: 23(8)

Published: Aug. 16, 2023

Abstract: Positive strides have been achieved in developing vaccines to combat the coronavirus-2019 infection (COVID-19) pandemic. Still, outline of variations, particularly most current delta divergent, has posed significant health encounters for people. Therefore, strong treatment strategies, such as an anti-COVID-19 medicine plan, may help deal with pandemic more effectively. During COVID-19 pandemic, some drug design techniques were effectively used develop and substantiate relevant critical medications. Extensive research, both experimental computational, dedicated comprehending characterizing devastating disease. The urgency situation led publication over 130,000 COVID-19-related research papers peer-reviewed journals preprint servers. A focus these efforts identification novel candidates repurposing existing drugs virus. Many projects utilized computational or computer-aided approaches facilitate their studies. In this overview, we will explore key methods applications discovery smallmolecule therapeutics COVID-19, reported literature. We believe that true effectiveness tools lies ability provide actionable experimentally testable hypotheses, which turn new combinations thereof. Additionally, recognize open science rapid sharing findings are vital expediting development much-needed COVID-19.

Language: Английский

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Calcitriol Downregulates ACE1/ACE2, Renin and TMPRSS2 Gene Expression in the Human Placenta

Published: Nov. 7, 2023

Angiotensin-converting enzyme (ACE)1, ACE2, and renin are components of the renin-angiotensin system (RAS), which regulates blood pressure. ACE2 also serves as a receptor for SARS-CoV-2 together with transmembrane serine protease 2 (TMPRSS-2), mediates viral cell-endocytosis. As placenta expresses all these factors, it acts target source pressure modulators. An ACE1/ACE2 ratio imbalance can lead to RAS dysregulation bad prognosis in COVID-19 patients. Calcitriol, vitamin D active metabolite, negatively RAS, reduces inflammation, enhances antiviral immunity, thereby playing protective role against severity. Placental calcitriol has been inversely correlated maternal pressure; however, its regulatory receptors within fetomaternal unit barely explored. Therefore, we investigated effects on placental components. Calcitriol downregulated ACE1, TMPRSS-2, gene expression cultured syncytiotrophoblasts extravillous trophoblast cell line HTR-8/SVneo. The was by calcitriol. Similar results were obtained treated calcidiol, precursor Altogether, support that is essential restricting infection while helping regulate during pregnancy.

Language: Английский

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Exploring demographical, clinical, and dietary determinants of vitamin D deficiency among adults in Douala, Cameroon during the COVID-19 era

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e24926 - e24926

Published: Feb. 1, 2024

Background and aimVitamin D deficiency (VDD) is a global public health problem in African populations. This study aimed at determining the prevalence, characteristics, determinants of VDD era SARS-CoV-2/COVID-19. was conducted from January to September 2022 seven facilities Douala, Cameroon.MethodsA structured, pre-tested questionnaire administered each participant collect participants' information. Molecular detection SARS-CoV-2 genome done. A serum level 25-hydroxyvitamin < 20 ng/mL used diagnose VDD.ResultsA total 420 participants were included study. Serum levels 25(OH) vitamin reduced (+) patients as compared (-) (21.69 ± 5.64 vs 42.09 20.03 ng/mL, p 0.0001). The overall prevalence 10.2 %. individuals had nearly two times more risk being (aRR = 1.81, by 46 % 71 those consuming cocoa bean or powder regularly 0.54, 0.03) rarely 0.29, 0.02) never it. Likewise, 59 78 sardine fish 0.47, 0.002) 0.22, 0.03). Overall, association between infection consistent, i.e., individuals, after stratification for confounding variables.ConclusionThis outlined high burden VDD, strong link SARS–CoV–2, suggests possible utility supplementation COVID-19 Cameroon.

Language: Английский

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Vitamin D and Mitochondrial Activity Preservation in COVID-19

Infectious Disorders - Drug Targets, Journal Year: 2024, Volume and Issue: 25(1)

Published: April 22, 2024

Language: Английский

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Immune Response after Anti-SARS-CoV-2 mRNA Vaccination in Relation to Cellular Immunity, Vitamin D and Comorbidities in Hemodialysis Patients

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 861 - 861

Published: April 25, 2024

In the global threat of SARS-CoV-2, individuals undergoing maintenance dialysis represent a vulnerable population with an increased risk severe COVID-19 outcomes. Therefore, immunization against SARS-CoV-2 is essential component healthcare strategy for these patients. Existing data indicate that they tend to exhibit reduced immune response vaccines compared general population. Our study aimed assess both humoral and cellular responses following two doses anti-SARS-CoV-2 mRNA vaccine, ability maintain adequate antibody titers over time, potential relations vitamin D, comorbidities other factors in hemodialysis patients based on single center experience. A total 41/45 (91.1%) responded second dose vaccine. The titer IgG class antibodies levels T cells three four weeks after vaccination were lower than healthy controls. Antibodies had positive correlation B lymphocytes was related cardiovascular diseases. level CD4+ negative vintage, as did D post-vaccination seroconversion decline during six months vaccination. Hemodialysis decreased amounts CD8+ chronic could lead diminished immunity protection from COVID-19. Comorbidity diseases associated specific titer. Vitamin may be important maintaining stable antibodies, while duration treatment one decreasing determining cell counts.

Language: Английский

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