Resolution of inflammation during rheumatoid arthritis DOI Creative Commons

Xiaoou Ye,

Dan Ren,

Qingyuan Chen

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 26, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes synovial joint inflammation as well bone destruction and erosion, typically characterized by pain, swelling, stiffness, with complications persistent pain after remission posing significant health burden for RA patients. The etiology of has not yet been fully elucidated, but large number studies have shown the initiation in closely related to T-cell activation, production variety pro-inflammatory cytokines, macrophage M1/M2 imbalance, homeostatic imbalance intestinal flora, fibroblast-like synoviocytes (FLSs) tissue macrophages (STMs) lumen joints exhibit an aggressive phenotype. While resolution less discussed, therefore, we provided systematic review relevant mechanisms including blocking T cell regulating polarization status, modulating signaling pathway FLSs, subpopulation STMs, inhibiting inflammatory factors, probable its management methods. Achieving crucial improving quality life long-term prognosis Thus, understanding these provide novel potential further drug development treatment RA.

Language: Английский

Dysregulated circular RNAs in rheumatoid arthritis: Cellular roles and clinical prospects DOI
Mengshi Tang, Hongxing Li,

Siyuan Chang

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103774 - 103774

Published: Feb. 1, 2025

Language: Английский

Citations

0
Resolution of inflammation during rheumatoid arthritis DOI Creative Commons

Xiaoou Ye,

Dan Ren,

Qingyuan Chen

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 26, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes synovial joint inflammation as well bone destruction and erosion, typically characterized by pain, swelling, stiffness, with complications persistent pain after remission posing significant health burden for RA patients. The etiology of has not yet been fully elucidated, but large number studies have shown the initiation in closely related to T-cell activation, production variety pro-inflammatory cytokines, macrophage M1/M2 imbalance, homeostatic imbalance intestinal flora, fibroblast-like synoviocytes (FLSs) tissue macrophages (STMs) lumen joints exhibit an aggressive phenotype. While resolution less discussed, therefore, we provided systematic review relevant mechanisms including blocking T cell regulating polarization status, modulating signaling pathway FLSs, subpopulation STMs, inhibiting inflammatory factors, probable its management methods. Achieving crucial improving quality life long-term prognosis Thus, understanding these provide novel potential further drug development treatment RA.

Language: Английский

Citations

0