The impact of sarcopenia on the efficacy of PD-1 inhibitors in non-small cell lung cancer and potential strategies to overcome resistance

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 19, 2024

Recent studies have revealed that sarcopenia can adversely affect the efficacy of PD-1 inhibitors in treatment non-small cell lung cancer (NSCLC). are immune checkpoint widely used various cancers. However, NSCLC patients may poorer outcomes when receiving inhibitor treatment, and through metabolic mechanisms. In this article, we summarize reported negative impact on effectiveness recent years. Based existing research results, analyze possible mechanisms by which affects discuss strategies to address issue. This could help understand provide more accurate expectations for clinicians patients. Additionally, present tailored intervention sarcopenic undergoing therapy, aiming optimize enhance patient quality life. Nevertheless, further is warranted elucidate impacts identify efficacious approaches improving

Language: Английский

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The effects of inspiratory muscle training with pulmonary rehabilitation on NSCLC patients during radiation therapy: A pilot clinical study

Thoracic Cancer, Journal Year: 2023, Volume and Issue: 14(17), P. 1567 - 1573

Published: April 20, 2023

Abstract Background The effects of inspiratory muscle training (IMT) with pulmonary rehabilitation (PR) on patients non‐small cell lung cancer (NSCLC) receiving radiotherapy (RT) have not previously been reported. This pilot study aimed to determine the effectiveness IMT PR respiratory muscles and exercise capacity NSCLC RT. Methods We retrospectively analyzed 20 who underwent RT for NSCLC. included IMT, stretching, strengthening, aerobic exercises three times a week 4 weeks concurrent lasted 10 min, consisting one cycle 30 breaths using Powerbreathe KH1 device in hospital by physical therapist. Patients two sessions at home daily an intensity approximately 30%–50% participant's maximum pressure (MIP) threshold tool. results from strength test, function 6‐min walk test (6MWT), cardiopulmonary endurance (CET), Inbody grip measurement, knee extensor/flexor Cancer Core Quality Life Questionnaire (EORTCQ‐C30), 13 (EORTC‐LC13). Results There were no adverse events during evaluation PR. MIP (60.1 ± 25.1 vs. 72.5 31.9, p = 0.005), 6MWT (439.2 97.1 60.7 97.8, 0.002), CET (181.39 193.12 123.6 87.6, 0.001), extensor (14.4 5.3 17.4 5, 0.012), flexor (14.0 5.2 16.9 5.5, 0.004) significantly improved after Conclusion appears effective without

Language: Английский

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Effect of inspiratory muscle training on hypoxemia in obese patients undergoing painless gastroscopy: protocol for a single-center, double-blind, randomized controlled trial

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 14, 2023

Introduction Obese patients who undergo painless gastroscopy are particularly prone to suffer from upper airway obstruction, respiratory depression, and subsequent hypoxemia. Despite adequate preoxygenation, the incidence of hypoxemia remains high. Recently, inspiratory muscle training (IMT) has been considered be a promising strategy increase strength endurance with attendant improvement pulmonary function. However, it unclear whether IMT is associated lower rate in obese during this sedative procedure. This study aims investigate effectiveness used scheduled for selective gastroscopy. Methods analysis prospective, randomized controlled trial (RCT) will enroll 232 body mass index (BMI) 35–39.9 kg·m −2 at First Affiliated Hospital Xiamen University. Subjects randomly assigned two groups 1:1 ratio. Participants both receive 4 weeks prior The intervention group load 30% maximal pressure (Pi(max)) first week, an 10% per week since following while counterparts control not any 4-week IMT. primary outcome Secondary outcomes include need maneuvers, blood changes, sleep quality assessment, pro-inflammatory cytokines levels, monitoring adverse events. Discussions offer invaluable guidance clinical implementation as potential non-invasive preventive measure. Additionally, stands enrich our comprehension anesthesia management airway-related challenges undergoing procedural sedation, which we anticipate further contribute addressing turnaround concerns within high-volume, swiftly paced ambulatory endoscopy centers. Ethics dissemination approved by Committee University (2022, No.091). results submitted publication peer-reviewed journals. Trial registration number China Clinical Center (ChiCTR2200067041).

Language: Английский

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Effects and Usefulness of Inspiratory Muscle Training Load in Patients with Advanced Lung Cancer with Dyspnea

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(10), P. 3396 - 3396

Published: May 10, 2023

Patients with advanced lung cancer tend to experience dyspnea. Pulmonary rehabilitation has been reported as a method for relieving However, exercise therapy imposes high burden on patients, and it is difficult sustain in many cases. Inspiratory muscle training (IMT) relatively low patients cancer; however, its benefits have not demonstrated. We retrospectively analyzed 71 who were hospitalized medical treatment. The participants divided into an group IMT load + group. Changes maximal inspiratory pressure (MIP) dyspnea examined using two-way repeated measures analysis of variance. MIP variations significantly increase the group, significant differences between baseline week 1, 1 2, 2. also showed that decreased results show useful persistence rate present cannot perform high-intensity therapy.

Language: Английский

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