Facing up to the global challenges of ageing

Nature, Journal Year: 2018, Volume and Issue: 561(7721), P. 45 - 56

Published: Aug. 30, 2018

Language: Английский

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Ageing and the pathogenesis of osteoarthritis

Nature Reviews Rheumatology, Journal Year: 2016, Volume and Issue: 12(7), P. 412 - 420

Published: May 19, 2016

Language: Английский

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Impact of intermittent fasting on health and disease processes

Ageing Research Reviews, Journal Year: 2016, Volume and Issue: 39, P. 46 - 58

Published: Oct. 31, 2016

Language: Английский

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Metformin as a Tool to Target Aging

Cell Metabolism, Journal Year: 2016, Volume and Issue: 23(6), P. 1060 - 1065

Published: June 1, 2016

Language: Английский

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Quantification of biological aging in young adults

Proceedings of the National Academy of Sciences, Journal Year: 2015, Volume and Issue: 112(30)

Published: July 6, 2015

Antiaging therapies show promise in model organism research. Translation to humans is needed address the challenges of an aging global population. Interventions slow human will need be applied still-young individuals. However, most research examines older adults, many with chronic disease. As a result, little known about young humans. We studied 954 humans, Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades life. developed validated two methods by which can measured one cross-sectional longitudinal. Our longitudinal measure allows quantification pace coordinated physiological deterioration organ systems (e.g., pulmonary, periodontal, cardiovascular, renal, hepatic, immune function). these assess biological who had not yet age-related diseases. Young individuals same chronological age varied "biological aging" (declining integrity systems). Already, before midlife, were more rapidly less physically able, showed cognitive decline brain aging, self-reported worse health, looked older. Measured adults used identify causes evaluate rejuvenation therapies.

Language: Английский

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The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Frontiers in Medicine, Journal Year: 2018, Volume and Issue: 5

Published: March 12, 2018

Geroscience, the new interdisciplinary field that aims to understand relationship between aging and chronic age-related diseases (ARDs) geriatric syndromes (GSs), is based on epidemiological evidence experimental data major risk factor for such pathologies assumes ARDs/GSs share a common set of basic biological mechanisms. A consequence primary target medicine combat instead any single ARD/GSs one by one, as favored fragmentation into hundreds specialties sub-specialties. If same molecular cellular mechanisms underpin both ARDs/GSs, question emerges: which difference, if any, ARDs/GSs? The hypothesis ARDs GSs frailty can be conceptualized accelerated will discussed analyzing in particular frailty, sarcopenia, obstructive pulmonary disease, cancer, neurodegenerative Alzheimer Parkinson well Down syndrome an example progeroid syndrome. According this integrated view, become part continuum where precise boundaries do not exist two extremes are represented centenarians, who largely avoided or postponed most characterized decelerated aging, patients suffered more severe their 60s, 70s, 80s show signs respectively. In these extremes, there intermediate trajectories representing sort gray area. Thus, clinically different, classical are, indeed, result peculiar combinations alterations regarding same, limited shared with process. Whether individual follow trajectory depend his/her genetic background interacting lifelong environmental lifestyle factors. manifestations it urgent identify markers capable distinguishing chronological age subjects at higher developing GSs. To aim, we propose use DNA methylation, N-glycans profiling, gut microbiota composition complement available disease-specific markers.

Language: Английский

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Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Sept. 25, 2019

Ageing is accompanied by remodeling of the immune system. With time, this leads to a decline in efficacy, resulting increased vulnerability infectious diseases, diminished responses vaccination, and susceptibility age-related inflammatory diseases. An age-associated alteration, extensively reported previous studies, reduction number peripheral blood naïve cells, with relative increase frequency memory cells. These two alterations, together inflamm-ageing, are considered hallmarks immunosenescence. Although ageing plastic process, it influenced both nutritional pharmacological interventions. Therefore, role nutrition immunomodulation immunosenescence discussed, due multifactorial influence on these hallmarks. The close connection between nutrition, intake bioactive nutrients supplements, function, inflammation demonstrate key dietary strategies as regulators response status, hence possible modulators rate In addition, potential options for therapeutic intervention clarified. particular, use interleukin-7 growth factor T function checkpoint inhibitors improving cell during and, drugs that inhibit mitogen-activated protein kinases their interaction nutrient signaling pathways discussed. Finally, suggested inclusion appropriate combinations toll-like receptor agonists may enhance efficacy vaccination older adults.

Language: Английский

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Lifespan and Healthspan: Past, Present, and Promise

The Gerontologist, Journal Year: 2015, Volume and Issue: 55(6), P. 901 - 911

Published: Nov. 10, 2015

The past century was a period of increasing life expectancy throughout the age range. This resulted in more people living to old and spending years at older ages. It is likely that increases ages will continue, but birth unlikely reach levels above 95 unless there fundamental change our ability delay aging process. We have yet experience much compression morbidity as onset most health problems has not increased markedly. In recent decades, been some reductions prevalence physical disability dementia. At same time, disease markedly, large part due treatment which extends for those with disease. Compressing or relative healthspan require "delaying aging" delaying physiological results disability. While moving expectancies compressing substantially may significant scientific breakthroughs; improvement United States could be achieved behavioral, style, policy changes reduce socioeconomic disparities allow us peer societies.

Language: Английский

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A research agenda for aging in China in the 21st century

Ageing Research Reviews, Journal Year: 2015, Volume and Issue: 24, P. 197 - 205

Published: Aug. 22, 2015

Language: Английский

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Evidence for a limit to human lifespan

Nature, Journal Year: 2016, Volume and Issue: 538(7624), P. 257 - 259

Published: Oct. 4, 2016

Language: Английский

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