Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 393 - 393

Published: March 25, 2024

The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM’s beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-κB phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.

Language: Английский

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Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: Mechanisms and interventions

Aging Cell, Journal Year: 2022, Volume and Issue: 21(10)

Published: Sept. 3, 2022

Abstract With the aging world population, prevalence of aging‐related disorders is on rise. Diseases such as Alzheimer's, type 2 diabetes mellitus (T2DM), Parkinson's, atherosclerosis, hypertension, and osteoarthritis are age‐related, most these diseases comorbidities or risk factors for AD; however, our understandings molecular events that regulate occurrence still not fully understood. Brain muscle Arnt‐like protein‐1 (Bmal1) an irreplaceable clock gene governs multiple important physiological processes. Continuous research Bmal1 in AD associated ongoing, this review picks relevant studies a detailed account its role mechanisms diseases. Oxidative stress inflammation turned out to be common by which deficiency promotes diseases, other Bmal1‐dependent remain identified. Promising therapeutic strategies involved regulation provided, including melatonin, natural compounds, metformin, d‐Ser2‐oxyntomodulin, interventions, exercise, time‐restricted feeding, adiponectin. The establishment signaling pathway network will lead advances comprehension cellular mechanisms, shedding light novel treatments promoting aging‐associated brain health.

Language: Английский

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Circadian misalignment impairs oligodendrocyte myelination via Bmal1 overexpression leading to anxiety and depression‐like behaviors

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(1)

Published: Jan. 1, 2024

Abstract Circadian misalignment (CM) caused by shift work can increase the risk of mood impairment. However, pathological mechanisms underlying these deficits remain unclear. In present study, we used long‐term variable photoperiod (L‐VP) in wild‐type mice to better simulate real‐life patterns and study its effects on prefrontal cortex (PFC) hippocampus, which are closely related function. The results showed that exposure L‐VP altered activity/rest rhythms mice, eliciting phase delay decreased amplitude rhythms. Mice with CM developed anxiety depression‐like manifestations number mature oligodendrocytes (OL) was reduced medial hippocampal CA1 regions. Mood impairment OL reduction worsened increased time L‐VP, while normal restoration had no effect. Mechanistically, identified upregulation Bmal1 PFC regions at night, when genes myelination should be highly expressed. exhibited significant inhibition protein kinase B (AKT)/mTOR signaling pathway, is directly associated differentiation maturation. Furthermore, demonstrated precursor cell line Oli‐Neu overexpression inhibits AKT/mTOR pathway reduces expression differentiation. conclusion, BMAL1 might play a critical role CM, providing strong research evidence for as potential target therapy.

Language: Английский

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New advances of adiponectin in regulating obesity and related metabolic syndromes

Journal of Pharmaceutical Analysis, Journal Year: 2023, Volume and Issue: 14(5), P. 100913 - 100913

Published: Dec. 13, 2023

Obesity and related metabolic syndromes have been recognized as important disease risks, in which the role of adipokines cannot be ignored. Adiponectin (ADP) is one key with various beneficial effects, including improving glucose lipid metabolism, enhancing insulin sensitivity, reducing oxidative stress inflammation, promoting ceramides degradation, stimulating adipose tissue vascularity. Based on those, it can serve a positive regulator many syndromes, such type 2 diabetes (T2D), cardiovascular diseases, non-alcoholic fatty liver (NAFLD), sarcopenia, neurodegenerative certain cancers. Therefore, promising therapeutic approach for treating diseases may involve elevating ADP levels or activating receptors. The modulation genes, multimerization, secretion covers main processes generation, providing comprehensive orientation development more appropriate strategies. In order to deeper understanding ADP, this paper will provide an all-encompassing review ADP.

Language: Английский

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Circadian regulation in aging: Implications for spaceflight and life on earth

Aging Cell, Journal Year: 2023, Volume and Issue: 22(9)

Published: July 26, 2023

Abstract Alterations in the circadian system are characteristic of aging on Earth. With decline physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle mass loss arise elderly populations. Similar risks reported as “red flag” among astronauts during after a long‐term Space exploration journey. However, little is known about common molecular alterations underlying terrestrial space‐related astronauts, controversial conclusions have been recently reported. In light regulatory role clock maintenance human health, we review here overlapping both Earth spaceflight with focus four most affected systems: visual, cardiovascular, central nervous, musculoskeletal systems. this review, briefly introduce specific cellular followed by those aging. We next summarize associated spaceflight, highlighting involved clock‐regulated genes space flown Drosophila , nematodes, small mammals, astronauts. Finally, discuss that altered terms their expression spaceflight. Altogether, data elaborated strengthen our hypothesis regarding timely need include dysregulation an emerging hallmark beyond.

Language: Английский

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Role of Bmal1 in Type 2 Diabetes Mellitus-Related Glycolipid Metabolic Disorder and Neuropsychiatric Injury: Involved in the Regulation of Synaptic Plasticity and Circadian Rhythms

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(8), P. 4595 - 4617

Published: May 1, 2023

Language: Английский

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BMAL1 in Astrocytes: A Protective Role in Alzheimer’s and Parkinson’s Disease

Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 1 - 1

Published: Jan. 2, 2025

Astrocyte activation is a critical aspect of brain health and disease, the central circadian clock protein BMAL1 has emerged as regulator astrogliosis inflammatory gene expression. Bmal1 deletion in astrocytes reprograms endolysosomal transcriptional pathways, inducing endocytosis, lysosomal degradation, autophagic activity. This regulation proteostasis by implicates proteins neurodegenerative diseases. Studies suggest that astrocyte complex process with diverse phenotypes beyond classic markers such GFAP, exhibiting neurotoxic neuroprotective effects. Deletion shown protective effects models Alzheimer’s disease (AD) Parkinson’s (PD), influencing Aβ accumulation α-syn pathology, respectively, through state mitigates tauopathy possibly induction chaperone BAG3. These findings crucial regulating astrocytic function neuroprotection review explores relationship between dysfunction development/progression AD PD. Furthermore, it recapitulates most recent on manipulating its potential astrocytes.

Language: Английский

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BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 6, 2025

Cognitive impairment is a significant complication of type 2 diabetes mellitus (T2DM). However, the mechanisms underlying development cognitive dysfunction in individuals with T2DM remain elusive. Herein, we discussed role Bmal1, core circadian rhythm-regulating gene, process T2DM-associated dysfunction. We identified marked decrease BMAL1 levels hippocampus db/db mice, followed by gain- and loss-of-function studies to explore impact on function. Our findings indicated that downregulation led deficits, characterized tau hyperphosphorylation accumulated amyloid plaque. Conversely, overexpression mitigated these Alzheimer-like pathologies. Further investigation revealed directly activated transcription Areg, thereby activating PI3K/Akt/GSK-3β pathway ameliorating Moreover, effects were attenuated LY294002, PI3K inhibitor. Collectively, results underscore impairment, proposing novel intervention strategy for exposed risk factors T2DM.

Language: Английский

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Importance of Gut Microbiota Dysbiosis and Circadian Disruption–Associated Biomarkers in Emergence of Alzheimer’s Disease

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

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Unveiling the ageing-related genes in diagnosing osteoarthritis with metabolic syndrome by integrated bioinformatics analysis and machine learning

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2025, Volume and Issue: 53(1), P. 57 - 68

Published: March 1, 2025

Ageing significantly contributes to osteoarthritis (OA) and metabolic syndrome (MetS) pathogenesis, yet the underlying mechanisms remain unknown. This study aimed identify ageing-related biomarkers in OA patients with MetS. MetS datasets genes (ARGs) were retrieved from public databases. The limma package was used differentially expressed (DEGs), weighted gene coexpression network analysis (WGCNA) screened modules, machine learning algorithms, such as random forest (RF), support vector (SVM), generalised linear model (GLM), extreme gradient boosting (XGB), employed. nomogram receiver operating characteristic (ROC) curve assess diagnostic value, CIBERSORT analysed immune cell infiltration. We identified 20 intersecting among DEGs of OA, key module MetS, ARGs. By comparing accuracy four models for disease prediction, SVM model, which includes CEBPB, PTEN, ARPC1B, PIK3R1, CDC42, selected. These hub ARGs not only demonstrated strong values based on data but also exhibited a significant correlation Building these findings, we have five that are associated infiltration constructed at early diagnosing

Language: Английский

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