The Fourth Annual Symposium of the Midwest Aging Consortium DOI Creative Commons
Jinoh Kim, Rochelle Buffenstein, Anne M. Bronikowski

et al.

The Journals of Gerontology Series A, Journal Year: 2024, Volume and Issue: 79(11)

Published: Nov. 1, 2024

Abstract The Midwest Aging Consortium (MAC) has emerged as a critical collaborative initiative aimed at advancing our understanding of aging and developing strategies to combat the rising prevalence age-related diseases. Founded in 2019, MAC brings together researchers from various disciplines institutions across Midwestern United States foster interdisciplinary geroscience research. This report summarizes highlights Fourth Annual Symposium MAC, which was held Iowa State University May 2023. symposium featured presentations on wide array topics, including studies slow-aging animals, cellular senescence senotherapeutics, role immune system aging, metabolic changes neuronal health biomarkers for measuring process. Speakers shared findings involving variety ranging commonly used species such mice, rats, worms, yeast, fruit flies, less-common ones like naked mole-rats, painted turtles, rotifers. continues emphasize importance supporting emerging fostering environment, positioning itself leader not only showcased current state biology research but also highlighted consortium’s training next generation scientists dedicated improving healthspan well-being population.

Language: Английский

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan DOI Creative Commons
Anissa A. Widjaja, Wei‐Wen Lim, Siva Viswanathan

et al.

Nature, Journal Year: 2024, Volume and Issue: 632(8023), P. 157 - 165

Published: July 17, 2024

For healthspan and lifespan, ERK, AMPK mTORC1 represent critical pathways inflammation is a centrally important hallmark

Language: Английский

Citations

70
Adipose tissue as a linchpin of organismal ageing DOI
Tammy Nguyen, Silvia Corvera

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(5), P. 793 - 807

Published: May 23, 2024

Language: Английский

Citations

21
The metabolic and functional roles of sensory nerves in adipose tissues DOI
Gargi Mishra, Kristy L. Townsend

Nature Metabolism, Journal Year: 2023, Volume and Issue: 5(9), P. 1461 - 1474

Published: Sept. 14, 2023

Language: Английский

Citations

25
Age‐related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment DOI Creative Commons
Jake W. Willows,

Morganne Robinson,

Zahra Alshahal

et al.

Aging Cell, Journal Year: 2023, Volume and Issue: 22(4)

Published: Feb. 16, 2023

Abstract Neural communication between the brain and adipose tissues regulates energy expenditure metabolism through modulation of tissue functions. We have recently demonstrated that under pathophysiological conditions (obesity, diabetes, aging), total subcutaneous white (scWAT) innervation is decreased (‘adipose neuropathy’). With advanced age in C57BL/6J mouse, small fiber peripheral nerve endings die back, resulting reduced contact with adipose‐resident blood vessels other cells. This vascular neuropathy parenchymal together likely pose a physiological challenge for function. In current work, we used genetically diverse HET3 mouse model to investigate incidence dysregulation across several ages both male female mice. also investigated anti‐aging treatment rapamycin, an mTOR inhibitor, as means prevent or reduce neuropathy. found mice displayed phenotype compared inbred C56BL/6 J mice, indicating genetic contributions this aging phenotype. Compared had worse neuropathic phenotypes by 62 weeks age. Female appeared increased protection from until (126 weeks), after reproductive senescence. rapamycin overall little impact on measures, actually worsened inflammation fibrosis. Despite its success longevity higher doses longer delivery paradigms may lead disconnect life span beneficial health outcomes.

Language: Английский

Citations

15
The Sympathetic Innervation of Adipose Tissues: Regulation, Functions, and Plasticity DOI
Jake W. Willows, Magdalena Blaszkiewicz, Kristy L. Townsend

et al.

Comprehensive physiology, Journal Year: 2023, Volume and Issue: unknown, P. 4985 - 5021

Published: June 26, 2023

The sympathetic nervous system (SNS) is a crucial arm of the peripheral (PNS) and includes catecholaminergic neurons that release norepinephrine (NE) onto numerous effector tissues organs in body. SNS innervation both white (WAT) brown adipose tissue (BAT) clearly essential for proper function metabolic control, as decades surgical, chemical, genetic denervation studies have demonstrated. Despite our vast knowledge about innervation, especially context cold-stimulated browning thermogenesis are under newer data now provide nuanced view supply to adipose, including its regulation by local neuroimmune cells neurotrophic factors, co-release modulatory neuropeptides along with NE, importance drive versus systemic increases circulating catecholamines, long-overlooked interplay between sensory nerves. This article brings modern patterns WAT BAT, how image quantify nerve supply, contributions functions, nerves respond remodeling plasticity changing energy demands. © 2023 American Physiological Society. Compr Physiol 13:4985-5021, 2023.

Language: Английский

Citations

15
Perivascular fat tissue and vascular aging: A sword and a shield DOI Creative Commons
Yan Wang, Xianmin Wang,

Yang chen

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107140 - 107140

Published: March 19, 2024

The understanding of the function perivascular adipose tissue (PVAT) in vascular aging has significantly changed due to increasing amount information regarding its biology. Adipose surrounding blood vessels is increasingly recognized as a key regulator disorders. It significant endocrine and paracrine effects on vasculature mediated by production variety bioactive chemicals. also participates number pathological regulatory processes, including oxidative stress, immunological inflammation, lipid metabolism, vasoconstriction, dilation. Mechanisms homeostasis interactions between cells at local level tightly regulate secretory repertoire PVAT, which can become dysregulated during aging. PVAT secretion group changes from being reducing inflammation lowering cholesterol response systemic or insulin resistance. In addition, interaction reciprocal, biological processes are directly influenced pertinent indicators architectural traits molecular mechanism crosstalk aging, clinical correlation age-related disorders all summarized this review. paper aims elucidate evaluate potential benefits therapeutically targeting context mitigating Furthermore, it will discuss latest advancements technology used for PVAT.

Language: Английский

Citations

5
Cellular and molecular evidence that synaptic Schwann cells contribute to aging of mouse neuromuscular junctions DOI Creative Commons
Robert Louis Hastings,

Mary Flordelys Avila,

Emma Suneby

et al.

Aging Cell, Journal Year: 2023, Volume and Issue: 22(11)

Published: Sept. 28, 2023

Abstract Age‐induced degeneration of the neuromuscular junction (NMJ) is associated with motor dysfunction and muscle atrophy. While impact aging on NMJ presynapse postsynapse well‐documented, little known about changes perisynaptic Schwann cells (PSCs), synaptic glia NMJ, undergo during aging. Here, we examined PSCs in young, middle‐aged, old mice three muscles different susceptibility to Using light electron microscopy, found that acquire age‐associated cellular features either prior or at same time as onset degeneration. Notably, aged fail completely cap even though they are more abundant compared young mice. We also form processes intrude into cleft guide axonal sprouts innervate other NMJs. next profiled transcriptome (SCs) identify mechanisms altered PSCs. This analysis revealed a transcriptional pattern previously shown promote phagocytosis absent SCs. It showed upregulate unique pro‐inflammatory molecules Interestingly, neither synaptogenesis genes nor typically upregulated by repair SCs were induced These findings provide insights molecular could be targeted stave off deleterious effects

Language: Английский

Citations

12
Gene therapy approaches for obesity-induced adipose neuropathy: Device-targeted AAV-mediated neurotrophic factor delivery to adipocytes in subcutaneous adipose DOI Creative Commons
Magdalena Blaszkiewicz,

Tianyi Tao,

Kofi Mensah-Arhin

et al.

Molecular Therapy, Journal Year: 2024, Volume and Issue: 32(5), P. 1407 - 1424

Published: March 1, 2024

Language: Английский

Citations

4
Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice DOI Creative Commons

Md Imam Faizan,

Gagandeep Kaur, Sadiya Bi Shaikh

et al.

Physiological Reports, Journal Year: 2025, Volume and Issue: 13(2)

Published: Jan. 1, 2025

Abstract The use of genetically diverse mouse models offers a more accurate reflection human genetic variability, improving the translatability findings to heterogeneous populations. This approach is particularly valuable in understanding immune responses disease by environmental exposures. study investigates inflammatory acute exposures mainstream cigarette smoke (CS) and tobacco (ETS) two strains, CC002/UncJ (UNC) & Diversity Outbred (J:DO). UM‐HET3 (HET3) strain, typically used aging intervention studies, has also been evaluate this model for age‐associated pathologies. involves comprehensive approach, including BALF cytokine analysis, evaluation lung tissue architecture, assessment macrophages its associated proteins (MMP9 MMP12) abundance. Several cytokines/chemokines were found be upregulated across three strains. Notably, UNC strain exclusively showed upregulation TNF‐α, IL‐17A, IL‐13, whereas J:DO an KC. number alveolar lungs mice was very low at baseline compared other strains studied study, which indicative some inherent shift pulmonary profiles these inbred mice. In contrast, characterized outbreeding, much robust macrophage response comparable C57BL/6J. provide insight into how diversity affects CS/ETS exposure, with implications stressors studying pathophysiology.

Language: Английский

Citations

0
Disaccharide Analysis of Glycosaminoglycans From Twenty‐Four Organs of Young and Aged Mice DOI Creative Commons
Emil Tykesson, Malin Eriksson, Jin‐Ping Li

et al.

Proteoglycan Research, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 1, 2025

ABSTRACT Glycosaminoglycans (GAGs) are abundant negatively charged polysaccharides ubiquitously expressed in mammalian organs, having essential biological functions development and homeostasis. It has been scarcely reported that GAG structures changed aged diseased human organs; however, an overall landscape of GAGs individual organs animal is missing. Here, we performed in‐depth analysis disaccharide composition chondroitin/dermatan sulfate (CS/DS) heparan (HS) from 24 young mice. Quantification the species showed CS/DS dominates almost all but HS five organs. As expected, sulfation pattern varied different which likely correlates with their a given organ. Nevertheless, age‐dependent alteration more prominent disaccharides CS/DS, may suggest important role aging. This first report comprehensive amount structure should be highly relevant understanding how affect diseases

Language: Английский

Citations

0