Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 20, 2023
Abstract
Background
Osteoarthritis
(OA),
the
most
common
type
of
arthritis,
is
a
highly
prevalent
age-related
joint
disease
particularly
in
subjects
over
65
years
old.
The
chronic
rise
senescent
cells
closely
correlates
with
diseases
including
OA,
and
senescence-associated
secretory
phenotype
(SASP)
implicated
pathogenesis
OA
cartilage
degeneration.
Sirtuin
6
(SIRT6)
probable
to
be
key
senescence-related
regulator.
Fisetin
(FST),
natural
flavonol
flavonoid
family,
recommended
senolytic
that
extends
health
lifespan.
However,
potential
chondroprotective
effects
FST
on
rats
remain
largely
unclarified.
This
study
aimed
investigate
ameliorative
relationship
SIRT6,
detailed
mechanisms
from
both
anti-inflammatory
anti-senescent
perspectives.
Methods
Rats
were
subjected
destabilization
medial
meniscus
(DMM)
surgery
induce
experimental
model
vivo.
Chondrocytes
treated
IL-1β
utilized
mimic
cell
vitro.
Intra-articular
injection
FST,
OSS_128167
(OSS,
SIRT6
inhibitor),
MDL800
(MDL,
agonist)
vivo
or
incubation
IL-1β-induced
rat
chondrocytes
vitro
performed
determine
link
SIRT6.
Results
level
was
negatively
correlated
severity.
downregulation
validated
cartilages
DMM
IL-1β-treated
chondrocytes.
Of
note,
We
demonstrated
could
activate
Both
administration
activation
using
MDL
rescued
erosion,
decreased
extracellular
matrix
(ECM)
degradation,
prevented
apoptosis,
improved
detrimental
phenotype.
alleviative
against
inflammation,
ECM
senescence
also
confirmed
IL-1β-stimulated
Conclusion
loss
occurs
articular
which
linked
aging.
attenuates
injury-induced
aging-related
changes
by
targeting
Materials & Design,
Journal Year:
2024,
Volume and Issue:
238, P. 112693 - 112693
Published: Jan. 25, 2024
Premature
ovarian
insufficiency
(POI)
may
lead
to
early
menopause,
fertility
loss
and
birth
defects
without
effective
treatment.
Here,
we
explored
the
efficacy
safety
of
gene
therapy
rescue
function
in
both
natural
aging
doxorubicin
(Dox)
induced
POI
mice.
Sirt1
Tgfbr2
were
screened
out
identified
as
key
genes
murine
human
tissues.
Then,
adenovirus
(AdV)
was
selected
a
suited
carrier
for
infection
after
comparison
multiple
viral
vectors.
In
two
models,
significantly
improved
AdV-Sirt1
AdV-Tgfbr2
invention
individually
or
combination,
obvious
side
effects
themselves
their
offspring.
Compared
with
control
group,
successful
pregnancy
rate
9-month-old-AdV-Sirt1
group
increased
by
60
%
(67
vs
42
%).
Meanwhile,
+
Dox
85
(55.6
20
The
biological
process
follicle
development
fibrosis
rescued.
Our
work
demonstrated
that
alleviates
Dox-associated
POI,
which
be
potentially
applicable
female
protection.
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 2243 - 2259
Published: Oct. 1, 2024
Background:
Skin
aging
is
the
most
obvious
feature
of
human
aging,
and
delaying
has
become
a
hot
difficult
research
topic
in
aesthetic
medicine.
The
accumulation
dysfunctional
senescent
cells
one
important
mechanisms
skin
based
on
which
series
anti-aging
strategies
have
been
generated.
In
this
paper,
from
perspective
cellular
senescence,
we
utilize
bibliometrics
review
to
explore
hotspots
trends
field,
with
view
providing
references
for
health
Methods:
We
obtained
literature
related
field
Web
Science
Core
Collection
database
1994
2024.
Bibliometrix
packages
R,
CiteSpace,
VOSviewer,
Origin,
Scimago
Graphica
were
utilized
data
mining
visualization.
Results:
A
total
2,796
documents
included
analysis.
overall
trend
publications
showed
continuous
rapid
increase
2016–
2023,
but
citations
improved
poorly
over
time.
Journal
Cosmetic
Dermatology,
Investigative
Experimental
Gerontology
are
core
journals.
Kim
J,
Lee
JH,
S,
Rattan
SIS,
Chung
JH
authors
field.
Seoul
National
University
first
terms
publications.
Korea
country
publications,
USA
citations.
Top
10
keywords
include:
gene-expression,
skin,
cell,
oxidative
stress,
antioxidants,
vitro,
fibroblasts,
mechanism,
cancer.
Current
focused
neurodegeneration,
rejuvenation,
molecular
docking,
fibrosis,
wound
healing,
SASP,
barrier,
antioxidants.
reflect
topics
such
as
major
pathways
process,
relationship
tumors.
Conclusion:
This
rapidly
rising
recent
years.
Relevant
focus
senescence-associated
secretory
phenotype.
Anti-aging
targeting
senescence
hold
great
promise,
including
removal
or
attenuation
SASP
factors,
corresponding
senolytics
senomorphics
therapies,
respectively.
Keywords:
medicine,
senolytic,
AJP Lung Cellular and Molecular Physiology,
Journal Year:
2024,
Volume and Issue:
327(4), P. L464 - L472
Published: Aug. 6, 2024
Chronic
obstructive
pulmonary
disease
(COPD)
is
regarded
as
an
accelerated-age
in
which
chronic
inflammation,
maladaptive
immune
responses,
and
senescence
cell
burden
coexist.
Accordingly,
cellular
has
emerged
a
potential
mechanism
involved
COPD
pathophysiology.
In
this
study,
25
stable
patients
with
underwent
daily
physical
activity
promotion
program
for
6
mo.
We
reported
that
increase
of
was
related
to
reduction
the
senescent
circulating
lymphocytes
COPD.
Senescent
T-lymphocyte
population,
characterized
by
absence
surface
expression
CD28,
reduced
after
intervention,
associated
level.
addition,
mRNA
cyclin-dependent
kinase
inhibitors,
hallmark
senescence,
and,
accordance,
proliferative
capacity
improved
postintervention.
Moreover,
we
observed
functionality
T
cells
from
including
markers
activation,
enhanced
cytotoxicity,
altered
cytokine
secretions
response
viral
challenge.
Lastly,
intervention
lymphocytes'
secretome
induce
human
primary
fibroblasts.
conclusion,
our
study
provides,
first
time,
evidence
reduce
cells.
Experimental Gerontology,
Journal Year:
2023,
Volume and Issue:
182, P. 112303 - 112303
Published: Sept. 30, 2023
Idiopathic
pulmonary
hypertension
(IPAH)
is
a
rare
and
severe
disease
that
affects
the
vasculature.
As
diagnosis
of
IPAH
requires
invasive
right
heart
catheterization
surgery,
early
detection
this
condition
notoriously
challenging.
Therefore,
it
utmost
importance
to
investigate
biomarkers
present
in
peripheral
blood
could
aid
physicians
identification
management
IPAH.We
speculate
cellular
senescence
may
be
involved
occurrence
development
through
various
pathways.
In
study,
we
utilized
integrated
transcriptome
analyses
machine
learning-based
approach
develop
diagnostic
model
for
cell
senescence.
To
select
genetic
features,
employed
two
learning
algorithms:
Least
Absolute
Shrinkage
Selection
Operator
(LASSO)
Random
Forest
(RF).
Additionally,
validated
our
findings
both
external
data
sets
qRT-PCR
experiments.The
resulting
nomogram
was
able
identify
five
important
can
IPAH,
including
TNFRSF1B,
CCL16,
GCLM,
IL15,
SOD1.
These
genes
are
primarily
associated
with
immune
system,
as
well
apoptosis.Our
study
demonstrates
utility
algorithms
making
accurate
diagnoses
providing
clinicians
more
directed
treatment
disease.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 20, 2023
Abstract
Background
Osteoarthritis
(OA),
the
most
common
type
of
arthritis,
is
a
highly
prevalent
age-related
joint
disease
particularly
in
subjects
over
65
years
old.
The
chronic
rise
senescent
cells
closely
correlates
with
diseases
including
OA,
and
senescence-associated
secretory
phenotype
(SASP)
implicated
pathogenesis
OA
cartilage
degeneration.
Sirtuin
6
(SIRT6)
probable
to
be
key
senescence-related
regulator.
Fisetin
(FST),
natural
flavonol
flavonoid
family,
recommended
senolytic
that
extends
health
lifespan.
However,
potential
chondroprotective
effects
FST
on
rats
remain
largely
unclarified.
This
study
aimed
investigate
ameliorative
relationship
SIRT6,
detailed
mechanisms
from
both
anti-inflammatory
anti-senescent
perspectives.
Methods
Rats
were
subjected
destabilization
medial
meniscus
(DMM)
surgery
induce
experimental
model
vivo.
Chondrocytes
treated
IL-1β
utilized
mimic
cell
vitro.
Intra-articular
injection
FST,
OSS_128167
(OSS,
SIRT6
inhibitor),
MDL800
(MDL,
agonist)
vivo
or
incubation
IL-1β-induced
rat
chondrocytes
vitro
performed
determine
link
SIRT6.
Results
level
was
negatively
correlated
severity.
downregulation
validated
cartilages
DMM
IL-1β-treated
chondrocytes.
Of
note,
We
demonstrated
could
activate
Both
administration
activation
using
MDL
rescued
erosion,
decreased
extracellular
matrix
(ECM)
degradation,
prevented
apoptosis,
improved
detrimental
phenotype.
alleviative
against
inflammation,
ECM
senescence
also
confirmed
IL-1β-stimulated
Conclusion
loss
occurs
articular
which
linked
aging.
attenuates
injury-induced
aging-related
changes
by
targeting
