Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 30, 2024
Abstract
Background
Ephrin-A4
(EFNA4)
is
present
in
numerous
tissues
and
connected
to
the
growth
development
of
multiple
types
cancer.
The
differences
EFNA4
expression
various
cancer
its
impact
on
glioblastoma
low-grade
glioma
(GBMLGG)
are
not
well
understood.
This
research
seeks
determine
prognostic
value
predicting
outcomes
GBMLGG
examine
role
tumorigenesis
GBMLGG.
Methods
Cancer
Genome
Atlas
(TCGA)
Genotype-Tissue
Expression
(GTEx)
databases
were
used
differential
genetic
alterations
EFNA4,
their
relationship
with
patient
survival
33
types.
Multiple
algorithms
correlation
between
infiltration
cancer-associated
fibroblasts,
immune
landscape,
immunomodulatory
genes,
tumor
mutational
burden
(TMB),
microsatellite
instability
(MSI)
score
Univariate
multivariate
Cox
regression
models
a
nomogram
developed
forecast
patients
We
also
established
protein-protein
interaction
networks,
identified
related
functional
signaling
pathways,
conducted
drug
sensitivity
analyses
progression
Results
In
most
cancer,
there
was
an
increase
mRNA
expression,
which
found
be
associated
prognosis.
had
positive
fibroblast
levels
types,
markedly
elevated
comparison
normal
Overexpression
significantly
correlated
progression,
poor
prognosis,
high
scores
status
demonstrated
ability
accurately
predict
Moreover,
it
discovered
that
considerable
genes
biological
processes
such
as
cell
infiltration,
tyrosine
kinase
pathway,
neurotransmitter
transmission
synapses,
epithelial-mesenchymal
transition
Conclusions
findings
this
indicate
has
great
potential
both
biomarker
target
for
therapy
Aging,
Journal Year:
2024,
Volume and Issue:
16(10), P. 9280 - 9302
Published: May 22, 2024
Aging
is
the
greatest
non-modifiable
risk
factor
for
most
diseases,
including
cardiovascular
diseases
(CVD),
which
remain
leading
cause
of
mortality
worldwide.
Robust
evidence
indicates
that
CVD
are
a
strong
determinant
reduced
brain
health
and
all-cause
dementia
with
advancing
age.
also
closely
linked
peripheral
cerebral
vascular
dysfunction,
common
contributors
to
development
progression
all
types
dementia,
largely
driven
by
excessive
levels
oxidative
stress
(e.g.,
reactive
oxygen
species
[ROS]).
Emerging
suggests
several
fundamental
aging
mechanisms
"hallmarks"
aging),
chronic
low-grade
inflammation,
mitochondrial
cellular
senescence
deregulated
nutrient
sensing
contribute
ROS
production
both
dysfunction.
Therefore,
targeting
these
reduce
ROS-related
improve
and/or
function
may
be
promising
strategy
aging.
Investigating
how
certain
lifestyle
strategies
aerobic
exercise
diet
modulation)
select
pharmacological
agents
(natural
synthetic)
intersect
promote
represent
viable
option
reducing
primary
purpose
this
review
explore
mechanistic
links
among
Such
insight
assessments
non-invasive
measures
might
provide
new
approach
assessing
in
older
adults.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 6, 2024
Abstract
The
role
of
senescence
in
disease
contexts
is
complex,
however
there
considerable
evidence
that
depletion
senescent
cells
improves
outcomes
a
variety
particularly
related
to
aging,
cognition,
and
neurodegeneration.
Here,
the
effect
bioinformatically-rationalized
senolytic
was
tested
experimental
autoimmune
encephalomyelitis
(EAE)
mouse
model
multiple
sclerosis
(MS).
Single-cell
analysis
from
brain
tissue
isolated
mice
subjected
EAE
identified
microglia
with
strong
signature
including
presence
BCL2-family
member
transcripts.
Cells
expressing
Bcl2l1
had
higher
expression
pro-inflammatory
genes
than
their
negative
counterparts
EAE,
suggesting
they
may
exacerbate
inflammation.
Notably,
human
single-nucleus
sequencing
MS,
BCL2L1
positive
were
strongly
enriched
lesions
active
inflammatory
pathology,
likewise
demonstrated
increased
immune
contribute
lesion
pathology
damage
chronic
lesions.
Employing
small
molecule
BCL2
inhibitor,
Navitoclax
(ABT-263),
significantly
reduced
spinal
cord,
these
can
be
targeted
by
treatment.
ABT-263
treatment
profound
on
mice,
decreasing
motor
symptom
severity,
improving
visual
acuity,
promoting
neuronal
survival,
white
matter
Together,
results
provide
support
idea
glia
inflammation
resulting
neuroinflammatory
removing
them
ameliorate
disease.
Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
15
Published: Sept. 14, 2023
The
neutrophil-to-lymphocyte
ratio
(NLR)
is
a
marker
of
inflammation
that
can
be
obtained
quickly,
conveniently,
and
cheaply
from
blood
samples.
However,
there
no
research
to
explore
the
effects
sex
age
on
relationship
between
NLR
mild
cognitive
impairment
(MCI)
in
community-dwelling
older
adults.A
total
3,126
individuals
aged
over
60
years
Shanghai
were
recruited
for
face-to-face
interviews,
samples
collected.
MCI
was
assessed
by
Mini-Mental
State
Examination
(MMSE)
Instrumental
Activities
Daily
Living
(IADL)
scale,
neutrophil
count
lymphocyte
counts
measured
fasting
calculated
dividing
absolute
count.In
females,
group
significantly
higher
than
cognitively
normal
(2.13
±
0.94
vs.
1.85
0.83,
p
<
0.001)
but
not
men.
Logistic
regression
showed
an
independent
risk
factor
women
[odds
(OR)
=
1.33;
95%
confidence
interval
(CI)
1.14-1.55].
In
addition,
elevated
quartile
associated
with
increased
MCI,
especially
70
(p
value
trend
0.012).Compared
males,
female
patients
had
controls.
found
years.
Therefore,
elderly
Chinese
may
target
population
effective
prevention
MCI.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 30, 2024
Abstract
Background
Ephrin-A4
(EFNA4)
is
present
in
numerous
tissues
and
connected
to
the
growth
development
of
multiple
types
cancer.
The
differences
EFNA4
expression
various
cancer
its
impact
on
glioblastoma
low-grade
glioma
(GBMLGG)
are
not
well
understood.
This
research
seeks
determine
prognostic
value
predicting
outcomes
GBMLGG
examine
role
tumorigenesis
GBMLGG.
Methods
Cancer
Genome
Atlas
(TCGA)
Genotype-Tissue
Expression
(GTEx)
databases
were
used
differential
genetic
alterations
EFNA4,
their
relationship
with
patient
survival
33
types.
Multiple
algorithms
correlation
between
infiltration
cancer-associated
fibroblasts,
immune
landscape,
immunomodulatory
genes,
tumor
mutational
burden
(TMB),
microsatellite
instability
(MSI)
score
Univariate
multivariate
Cox
regression
models
a
nomogram
developed
forecast
patients
We
also
established
protein-protein
interaction
networks,
identified
related
functional
signaling
pathways,
conducted
drug
sensitivity
analyses
progression
Results
In
most
cancer,
there
was
an
increase
mRNA
expression,
which
found
be
associated
prognosis.
had
positive
fibroblast
levels
types,
markedly
elevated
comparison
normal
Overexpression
significantly
correlated
progression,
poor
prognosis,
high
scores
status
demonstrated
ability
accurately
predict
Moreover,
it
discovered
that
considerable
genes
biological
processes
such
as
cell
infiltration,
tyrosine
kinase
pathway,
neurotransmitter
transmission
synapses,
epithelial-mesenchymal
transition
Conclusions
findings
this
indicate
has
great
potential
both
biomarker
target
for
therapy
