Telomere length and micronuclei trajectories in APP/PS1 mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner

Aging Cell, Journal Year: 2024, Volume and Issue: 23(5)

Published: March 7, 2024

Abstract Although studies have demonstrated that genome instability is accumulated in patients with Alzheimer's disease (AD), the specific types of linked to AD pathogenesis remain poorly understood. Here, we report first characterization age‐ and sex‐related trajectories telomere length (TL) micronuclei APP/PS1 mice model wild‐type (WT) controls (C57BL/6). TL was measured brain (prefrontal cortex, cerebellum, pituitary gland, hippocampus), colon skin, MN bone marrow 6‐ 14‐month‐old mice. Variation attributable tissue type, age, genotype and, a lesser extent, sex. Compared WT, had significantly shorter baseline across all examined tissues. inversely associated age both genotypes shortening accelerated APP/PS1. Age‐related increase observed but We integrated data on cognition performance amyloidosis. were linearly correlated or Aβ 40 42 levels greater extent These associations dominantly driven by females. Together, our findings provide foundational knowledge infer during progression, strongly support attrition micronucleation are tightly female‐biased manner.

Language: Английский

Association between telomere length and erectile dysfunction: a cross-sectional study

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 11, 2024

Background Leukocyte telomere length (LTL) serves as a significant biomarker of aging. Erectile dysfunction (ED) is commonly observed condition among middle-aged and older men. The objective this study to explore the potential association between LTL ED. Methods We utilized data from National Health Nutrition Examination Survey (NHANES) examine Weighted multivariate regression analyses were performed primary statistical method. Subgroup conducted investigate specific population subsets, restricted cubic spline (RCS) employed assess non-linear relationship Results results weighted revealed negative correlation risk Individuals with ED exhibited shorter compared those without For each unit increase in LTL, there was 54% reduction (odds ratios[OR] 0.46, 95% confidence intervals[CI] 0.25-0.85). When considered categorical variable, group longest (Q5) had 44% lower shortest LTL(Q1) (OR 0.56, CI 0.39-0.81). A TL Various sensitivity validate stability results, consistent findings obtained. Conclusion leukocyte suggests that delaying shortening may decrease

Language: Английский