Senolytic Vaccines from the Central and Peripheral Tolerance Perspective DOI Creative Commons
Maria Vasilieva, Rimma O. Shatalova,

Kseniia S. Matveeva

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1389 - 1389

Published: Dec. 10, 2024

Preventive medicine has proven its long-term effectiveness and economic feasibility. Over the last century, vaccination saved more lives than any other medical technology. At present, preventative measures against most infectious diseases are successfully used worldwide; in addition, platforms oncological even autoimmune being actively developed. same time, development of led to an increase both life expectancy proportion age-associated diseases, which pose a heavy socio-economic burden. In this context, vaccine-based approaches for prevention or treatment age-related opens up broad prospects extending period active longevity high potential. It is well known that associated with accumulation senescent cells various organs tissues. been demonstrated elimination such leads restoration functions, rejuvenation, extension experimental animals. However, vaccines complicated by their antigenic heterogeneity lack unique marker. body’s own cells, may be reason low immunogenicity. This mini-review discusses mechanisms central peripheral tolerance influence formation anti-senescent immune response responsible age.

Language: Английский

Beyond the Hayflick limit: How microbes influence cellular aging DOI
Mohammad Abavisani,

Saba Faraji,

Negar Ebadpour

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102657 - 102657

Published: Jan. 7, 2025

Language: Английский

Citations

2
Caco2/HT-29 In Vitro Cell Co-Culture: Barrier Integrity, Permeability, and Tight Junctions’ Composition During Progressive Passages of Parental Cells DOI Creative Commons
Elena Donetti, Paola Bendinelli, Margherita Correnti

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 267 - 267

Published: March 6, 2025

Epithelial linings are crucial for the maintenance of physiological barriers. The intestinal epithelial barrier (IEB) consists enterocytes through tight junctions and mucus-secreting cells can undergo modifications throughout life. To reproduce as closely possible IEB main features over time, in vitro co-cultures Caco2/HT-29 70/30 formed by parental Caco2 HT-29 sub-cultivated more than 40 passages were set up. measurements transepithelial electrical resistance (TEER) identified two populations: TEER (PC) with values > 50 Ωcm2 fewer passages, leaky (LC) < passages. In LC, paracellular permeability increased parallel. By immunofluorescence Western blot analysis, an increase claudin 2 was observed LC vs. PC, no differences occludin expression. MUC-2 immunoreactivity stronger PC LC. also showed enhanced vulnerability to TNFα+IFN-γ. These results morpho-functional reported human leaky/aged gut support usefulness our cell model studying molecular processes underlying these testing drug/nutraceutical treatments ameliorate aging.

Language: Английский

Citations

1
The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review DOI Creative Commons
D.S. Jang, J W Shin, Eunha Shim

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: 23(10)

Published: Aug. 15, 2024

Abstract The intricate interplay between cellular senescence and alterations in the gut microbiome emerges as a pivotal axis aging process, increasingly recognized for its contribution to systemic inflammation, physiological decline, predisposition age‐associated diseases. Cellular senescence, characterized by cessation of cell division response various stressors, induces morphological functional changes within tissues. complexity heterogeneity senescent cells, alongside secretion senescence‐associated secretory phenotype, exacerbate process through pro‐inflammatory pathways influence microenvironment immune system. Concurrently, aging‐associated diversity composition contribute dysbiosis, further exacerbating inflammation undermining integrity bodily functions. This review encapsulates burgeoning research on reciprocal relationship highlighting their collective impact age‐related musculoskeletal diseases, including osteoporosis, sarcopenia, osteoarthritis. It also explores potential modulating targeting innovative strategies healthy mitigating progression aging‐related conditions. By exploring targeted interventions, development senotherapeutic drugs probiotic therapies, this aims shed light novel therapeutic avenues. These leverage connection advance interventions aimed at extending health span improving quality life older population.

Language: Английский

Citations

6
Unraveling the link between metabolic dysfunction-associated steatotic liver disease and osteoporosis: a bridging function of gut microbiota DOI Creative Commons
Jing Zhang, Zhen Sun,

Lili Xu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

This review examines the strong association between metabolic dysfunction-associated steatotic liver disease (MASLD) and osteoporosis (OP), with a particular focus on role of gut microbiota in linking these two disorders. Both MASLD OP are closely linked to syndrome, their pathogenesis involves multiple factors, such as inflammatory response, insulin resistance, altered intestinal permeability, estrogen deficiency. Dysregulation not only affects hepatic fat accumulation bone metabolism disorders through metabolites, short-chain fatty acids, but also exacerbates systemic chronic inflammation by impairing barrier function, thus accelerating progression both diseases. article summarizes recent studies that highlight central co-morbid factor OP, offering new perspectives for future diagnostic therapeutic strategies.

Language: Английский

Citations

0
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations DOI Creative Commons
Lyndon E. Mansfield, Valentina Ramponi, Kavya Gupta

et al.

npj Aging, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 22, 2024

Abstract Senescence is a crucial hallmark of ageing and significant contributor to the pathology age-related disorders. As committee members young International Cell Association (yICSA), we aim synthesise recent advancements in identification, characterisation, therapeutic targeting senescence for clinical translation. We explore novel molecular techniques that have enhanced our understanding senescent cell heterogeneity their roles tissue regeneration pathology. Additionally, delve into vivo models senescence, both non-mammalian mammalian, highlight tools available advancing contextual senescence. Furthermore, discuss innovative diagnostic senotherapeutic approaches, emphasising potential application. Future directions research are explored, underscoring need precise, context-specific classification integration advanced technologies such as machine learning, long-read sequencing, multifunctional senoprobes senolytics. The dual role promoting homoeostasis contributing chronic diseases highlights complexity these cells improved outcomes.

Language: Английский

Citations

1
Senolytic Vaccines from the Central and Peripheral Tolerance Perspective DOI Creative Commons
Maria Vasilieva, Rimma O. Shatalova,

Kseniia S. Matveeva

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1389 - 1389

Published: Dec. 10, 2024

Preventive medicine has proven its long-term effectiveness and economic feasibility. Over the last century, vaccination saved more lives than any other medical technology. At present, preventative measures against most infectious diseases are successfully used worldwide; in addition, platforms oncological even autoimmune being actively developed. same time, development of led to an increase both life expectancy proportion age-associated diseases, which pose a heavy socio-economic burden. In this context, vaccine-based approaches for prevention or treatment age-related opens up broad prospects extending period active longevity high potential. It is well known that associated with accumulation senescent cells various organs tissues. been demonstrated elimination such leads restoration functions, rejuvenation, extension experimental animals. However, vaccines complicated by their antigenic heterogeneity lack unique marker. body’s own cells, may be reason low immunogenicity. This mini-review discusses mechanisms central peripheral tolerance influence formation anti-senescent immune response responsible age.

Language: Английский

Citations

0