FOXOs and their roles in acute and chronic neurological disorders DOI Creative Commons

Yasin Asadi,

Rozenn K. Moundounga,

Anand Chakroborty

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: April 7, 2025

The forkhead family of transcription factors class O (FOXOs) consisting four functionally related proteins, FOXO1, FOXO3, FOXO4, and FOXO6, are mammalian homologs daf-16 in Caenorhabditis elegans were previously identified as tumor suppressors, oxidative stress sensors, cell survival modulators. Under normal physiological conditions, FOXO protein activities negatively regulated by phosphorylation via the phosphoinositide 3-kinase (PI3K)-Akt pathway, a well-known pathway: Akt phosphorylates FOXOs to inactivate their transcriptional activity relocalizing from nucleus cytoplasm for degradation. However, under or absent cellular drive growth factors, proteins translocate upregulate series target genes, thereby promoting arrest death altering mitochondrial homeostasis. gene expression is also other such p53 autoregulation end products. Here we summarize structure, posttranslational modifications, translocation linking control functions, survival, death, emphasizing role regulating response some acute insults chronic neurological disorders. This review will conclude with brief section on potential therapeutic interventions that can be used modulate FOXOs’ when treating

Language: Английский

Natural Products Targeting Tau Protein Phosphorylation: A Promising Therapeutic Avenue for Alzheimerʼs Disease DOI Creative Commons
Ziying Chen, Lu Yan, Yiyun Wang

et al.

Planta Medica, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract Alzheimerʼs disease is a progressive neurodegenerative disorder characterized by tau protein hyperphosphorylation and neurofibrillary tangle formation, which are central to its pathogenesis. This review focuses on the therapeutic potential of natural products in targeting phosphorylation, key factor progression. It comprehensively summarizes current research various compounds, including flavonoids, alkaloids, saponins, polysaccharides, phenols, phenylpropanoids, terpenoids, highlighting their multitarget mechanisms, such as modulating kinases phosphatases. The ability these compounds mitigate oxidative stress, inflammation, pathology while enhancing cognitive function underscores value anti-Alzheimerʼs therapeutics. By integrating recent advances extraction methods, pharmacological studies, artificial intelligence-driven screening technologies, this provides valuable reference for future development product-based interventions disease.

Language: Английский

Citations

0
FOXOs and their roles in acute and chronic neurological disorders DOI Creative Commons

Yasin Asadi,

Rozenn K. Moundounga,

Anand Chakroborty

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: April 7, 2025

The forkhead family of transcription factors class O (FOXOs) consisting four functionally related proteins, FOXO1, FOXO3, FOXO4, and FOXO6, are mammalian homologs daf-16 in Caenorhabditis elegans were previously identified as tumor suppressors, oxidative stress sensors, cell survival modulators. Under normal physiological conditions, FOXO protein activities negatively regulated by phosphorylation via the phosphoinositide 3-kinase (PI3K)-Akt pathway, a well-known pathway: Akt phosphorylates FOXOs to inactivate their transcriptional activity relocalizing from nucleus cytoplasm for degradation. However, under or absent cellular drive growth factors, proteins translocate upregulate series target genes, thereby promoting arrest death altering mitochondrial homeostasis. gene expression is also other such p53 autoregulation end products. Here we summarize structure, posttranslational modifications, translocation linking control functions, survival, death, emphasizing role regulating response some acute insults chronic neurological disorders. This review will conclude with brief section on potential therapeutic interventions that can be used modulate FOXOs’ when treating

Language: Английский

Citations

0