Pyrroloquinoline-quinone supplementation restores ovarian function and oocyte quality in a mouse model of advanced maternal age DOI
Kemei Zhang, Rui Xu, Jinzhao Ma

et al.

Biology of Reproduction, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract Natural ovarian aging is one of the major causes for declining fertility in female animals, which has become an insurmountable issue human reproduction clinics and assisted reproductive technology procedures. Nevertheless, molecular basis oocyte remains poorly understood, feasible improvement strategies are unavailable. In present study, vivo supplementation pyrroloquinoline-quinone effectively elevated fecundity reproductively aged mice by balancing hormonal secretion, harmonizing estrus cycle, eliminating fibrosis. Moreover, quality also increased after administration from various aspects, including nuclear cytoplasmic maturation competency, fertilization capacity, pre-implantation embryonic development potential. Transcriptomic analysis identified target pathways that might mediate pyrroloquinoline-quinone’s effects oocytes. Specifically, it was demonstrated restored mitochondrial dynamics lysosomal function to remove excessive reactive oxygen species suppress apoptosis Jointly, these findings demonstrate efficacious method restore compromised ovary damaged mice, be a potential clinical therapy women advanced maternal age with infertility.

Language: Английский

Pyrroloquinoline-quinone supplementation restores ovarian function and oocyte quality in a mouse model of advanced maternal age DOI
Kemei Zhang, Rui Xu, Jinzhao Ma

et al.

Biology of Reproduction, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract Natural ovarian aging is one of the major causes for declining fertility in female animals, which has become an insurmountable issue human reproduction clinics and assisted reproductive technology procedures. Nevertheless, molecular basis oocyte remains poorly understood, feasible improvement strategies are unavailable. In present study, vivo supplementation pyrroloquinoline-quinone effectively elevated fecundity reproductively aged mice by balancing hormonal secretion, harmonizing estrus cycle, eliminating fibrosis. Moreover, quality also increased after administration from various aspects, including nuclear cytoplasmic maturation competency, fertilization capacity, pre-implantation embryonic development potential. Transcriptomic analysis identified target pathways that might mediate pyrroloquinoline-quinone’s effects oocytes. Specifically, it was demonstrated restored mitochondrial dynamics lysosomal function to remove excessive reactive oxygen species suppress apoptosis Jointly, these findings demonstrate efficacious method restore compromised ovary damaged mice, be a potential clinical therapy women advanced maternal age with infertility.

Language: Английский

Citations

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