Impact of Alcohol Consumption on Male Fertility Potential: A Narrative Review

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 19(1), P. 328 - 328

Published: Dec. 29, 2021

Alcohol abuse disorder is a serious condition, implicating more than 15 million people aged 12 years and older in 2019 the United States. Ethanol (or ethyl alcohol) mainly oxidized liver, resulting synthesis of acetaldehyde acetate, which are toxic carcinogenic metabolites, as well generation reductive cellular environment. Moreover, ethanol can interact with lipids, generating fatty acid esters phosphatidylethanol, interfere physiological pathways. This narrative review summarizes impact excessive alcohol consumption on male fertility by describing its metabolism how may induce damage. Furthermore, hormonal regulation, semen quality, genetic epigenetic regulations discussed based evidence from animal human studies, focusing consequences offspring. Finally, limitations current discussed. Our highlights association between chronic poor due to development oxidative stress, genotoxic regulation DNA integrity, affecting offspring's health. New landscapes investigation proposed for identification molecular markers alcohol-associated infertility, focus advanced OMICS-based approaches applied analysis samples.

Language: Английский

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Maternal, Paternal, and Dual-Parental Alcohol Exposures Result in Both Overlapping and Distinct Impacts on Behavior in Adolescent Offspring

Alcohol, Journal Year: 2025, Volume and Issue: 124, P. 65 - 77

Published: Jan. 22, 2025

Language: Английский

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Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming

Epigenetics & Chromatin, Journal Year: 2019, Volume and Issue: 12(1)

Published: Jan. 22, 2019

Although clinical data support an association between paternal alcohol use and deficits in child neurocognitive development, the relationship drinking alcohol-induced growth phenotypes remains challenging to define. Using established mouse model of chronic exposure, previous work by our group has linked preconception sex-specific patterns fetal restriction placental dysfunction. The aim present study was investigate long-term impact on offspring metabolic programming. Preconception exposure induced a prolonged period gestation increased incidence intrauterine restriction, which affected male greater extent than females. While female ethanol-exposed males were able match body weights controls within first 2 weeks postnatal life, continued display 11% reduction weight at 5 age 6% 8 age. observed associated with insulin hypersensitivity offspring, while contrast, females displayed modest lag their glucose tolerance test. These defects up-regulation genes pro-fibrotic TGF-β signaling pathway levels cellular hydroxyproline livers offspring. We suppressed cytokine profiles liver pancreas both correlated LiverX/RetinoidX/FarnesoidX receptor pathways. However, gene expression highly variable alcohol-exposed sires. In adult males, we did not observe any differences allelic Igf2 or other imprinted genes. development is poorly explored represents significant gap understanding teratogenic effects ethanol. Our studies implicate history as additional important modifier challenge current maternal-centric paradigm.

Language: Английский

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Oxidative Stress in Male Infertility: Causes, Effects in Assisted Reproductive Techniques, and Protective Support of Antioxidants

Biology, Journal Year: 2020, Volume and Issue: 9(4), P. 77 - 77

Published: April 10, 2020

The spermatozoon is a highly specialized cell, whose main function the transport of intact male genetic material into oocyte. During its formation and transit throughout female reproductive tracts, sperm cells are internally externally surrounded by reactive oxygen species (ROS), which produced from both endogenous exogenous sources. While low amounts ROS known to be necessary for crucial physiological processes, such as acrosome reaction sperm–oocyte interaction, high levels those underlie misbalanced antioxidant-oxidant molecules, generating oxidative stress (OS), one most damaging factors that affect lower fertility potential. present work starts reviewing different sources cells, continues summarizing detrimental effects OS on germline, discusses previous studies addressing consequences these natural pregnancy assisted techniques effectiveness. last section focused how antioxidants can counteract fertilizing ability may benefit agents.

Language: Английский

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Alterations in sperm-inherited noncoding RNAs associate with late-term fetal growth restriction induced by preconception paternal alcohol use

Reproductive Toxicology, Journal Year: 2019, Volume and Issue: 87, P. 11 - 20

Published: April 30, 2019

Language: Английский

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Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: May 25, 2022

Abstract Using a mouse model, studies by our group reveal that paternal preconception alcohol intake affects offspring fetal-placental growth, with long-lasting consequences on adult metabolism. Here, we tested the hypothesis chronic male exposure impacts histone enrichment in sperm and these changes are associated altered developmental programming placenta. chromatin immunoprecipitation, find alcohol-induced increases H3 lysine 4 trimethylation (H3K4me3) map to promoters presumptive enhancer regions enriched genes driving neurogenesis craniofacial development. Given colocalization of H3K4me3 binding factor CTCF across both embryos, next examined localization We global within placentae derived from alcohol-exposed sires. Furthermore, correlates dysregulated gene expression multiple clusters; however, transcriptional only occur offspring. Finally, identified correlation between genomic exhibiting increased placentae. Collectively, analysis demonstrates landscape is sensitive subset affected exhibits placental enrichment.

Language: Английский

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Influence of substance use on male reproductive health and offspring outcomes

Nature Reviews Urology, Journal Year: 2024, Volume and Issue: 21(9), P. 534 - 564

Published: April 25, 2024

Language: Английский

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The Impact of Paternal Alcohol Consumption on Offspring Brain and Behavioral Development

Alcoholism Clinical and Experimental Research, Journal Year: 2019, Volume and Issue: 44(1), P. 125 - 140

Published: Nov. 20, 2019

Background Fetal alcohol spectrum disorders (FASD) describe the wide array of long‐lasting developmental abnormalities in offspring due to prenatal (ethanol [EtOH]) exposure via maternal gestational drinking. Although teratogenic consequences EtOH exposure, are apparent, effects preconception paternal (PatEE) still unclear. Previous research suggests that PatEE can induce molecular changes and abnormal behavior offspring. However, it is not known whether impacts development neocortex as demonstrated consumption models FASD (J Neurosci, 33, 2013, 18893). Methods In this study, we utilized a novel mouse model where male mice self‐administered 25% for an extended period prior conception, generating indirect through germline. Following mating, examined on neocortical at postnatal day (P) 0 evaluated several aspects both P20 P30 using battery behavioral assays. Results resulted significant impact development, including patterns gene expression within P0 subtle alterations intraneocortical connections. Additionally, exhibited sex‐specific increase activity sensorimotor integration deficits P20, decreased balance, coordination, short‐term motor learning P30. This may generate long‐lasting, behavior. Conclusions These results demonstrate more harmful than previously thought provide additional insights into biological mechanisms underlie atypical observed children alcoholic fathers.

Language: Английский

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Fathers matter from the start: The role of expectant fathers in child development

Child Development Perspectives, Journal Year: 2021, Volume and Issue: 16(1), P. 54 - 59

Published: Dec. 14, 2021

Abstract Extensive research has established that fathers’ engagement in parenting benefits children, but few studies have described how fathers contribute to child development even before birth. In this article, we consider both direct and indirect pathways through which expectant shape during the prenatal period. Regarding pathways, review work on contributions genetic epigenetic processes, as well neuroendocrine mechanisms. outline ways indirectly influence couple relationship. so doing, seek provide a foundation from formulate future lines of inquiry role development. This can inform clinical interventions policies geared toward improving early caregiving environment

Language: Английский

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Adolescent Substance Abuse, Transgenerational Consequences and Epigenetics

Current Neuropharmacology, Journal Year: 2021, Volume and Issue: 19(9), P. 1560 - 1569

Published: March 3, 2021

Adolescence is the transitional period between childhood and adulthood a critical in brain development. humans also associated with increased expression of risk-taking behaviors. Epidemiological clinical studies, for example, show surge drug abuse raise hypothesis that adolescent undergoes changes resulting diminished control. Determining how substance during this might cause longterm neurobiological cognition behavior therefore critically important. The present work aims to provide an evaluation transgenerational multi-generational phenotypes derived from parent animals exposed drugs only their adolescence. Specifically, we will consider found following administration cannabinoids, nicotine, alcohol opiates. In addition, epigenetic modifications genome exposure be discussed as emerging evidence underlying adverse effects. Notwithstanding, much new data here animal models, indicating future studies are needed better understand consequences mechanisms actions on human brains' development maturation.

Language: Английский

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