Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors

Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract Rationale Alcohol is one of the most frequently used drugs abuse and has a major impact on human health worldwide. People assigned female at birth those with adverse childhood experiences are stress-vulnerable more likely to report drinking as means “self-medication.” Prior studies in our laboratory showed that adolescent social isolation stress (SIS) increases vulnerability ethanol (EtOH) intake consumption despite negative consequences rats. Objectives Here, we explored modulation dorsal raphe nucleus (DRN)-serotonin (5-HT) system, sexually dimorphic neurotransmitter system involved stress-reward interactions, determine its contribution EtOH-motivated behaviors rats have undergone SIS. Results We employed electrophysiological functional neuroanatomy strategies show both SIS EtOH exposure induce persistent hypofunction DRN 5-HT particularly females. Chemogenetic activation neurons attenuated reward value for sucrose elevated punished responding stress-dependent manner. Conclusions Our results highlight an inverse relationship between sex- nature this relationship, connection signaling acute rewards punishment. These data support potential target treat aberrant alcohol populations.

Language: Английский

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Is the Relationship Between Adolescent Social Isolation and Anxiety‐Like Behaviors Altered by Microglia Ablation in Female Long Evans Rats?

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

Despite extensive, cross-disciplinary research revealing a relationship between early life stress (ELS) and an increased risk for neuropsychiatric disorders, the underlying processes mediating this are not fully understood. Further, majority of preclinical studies investigating have taken sex differences into consideration. A growing body work suggests that microglia, resident immune cells brain, impacted by ELS contribute to some maladaptive behavioral phenotypes in adulthood. Here, we utilized adolescent social isolation (aSI) model female rats test role microglia effects on anxiety-related behaviors. The present study sought determine whether ablation during aSI could prevent anxiety-like behaviors Long Evans rats. colony-stimulating factor 1 receptor (CSF1-r) inhibitor, PLX3397, was provided chow ablate at start period (postnatal day (P) 21-42). During period, animals performed battery assays including open field test, elevated plus maze, successive alleys test. Following completion assays, brain tissue collected confirm efficacy PLX3397 identify changes population density. Relative group-housed (GH) controls, showed locomotor activity higher closed-arm entries maze. Although effectively ablated across all animals, treatment had minimal observed aSI-associated phenotypes. Together, these data suggest required adaptations promoted aSI. Future will be needed assess

Language: Английский

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Effects of social isolation on locus coeruleus opioid receptor expression and affective behavior.

Neurobiology of Stress, Journal Year: 2025, Volume and Issue: unknown, P. 100717 - 100717

Published: March 1, 2025

Language: Английский

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Effects of Social Isolation on Locus Coeruleus Opioid Receptor Expression and Affective Behavior

Published: Jan. 1, 2024

Language: Английский

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