Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals DOI Creative Commons
Hai-ling Cao, Wei Wei, Yajing Meng

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 220, P. 111166 - 111166

Published: Dec. 10, 2024

Alcohol dependence (AD) is an addictive disorder with multifaceted neurobiological features. Recent research on the pathophysiological mechanisms of AD has emphasized important role dysconnectivity. Cortical gyrification known to be a reliable marker neural connectivity. This study aimed explore cortical using local index (LGI) between alcohol-dependent patients and controls. Magnetic resonance images were collected from 60 early abstinent (5-12 days after stopping alcohol consumption) 59 controls preprocessed FreeSurfer, followed by surface-based morphometry (SBM) analysis compare LGI two groups. Cognitive performance was assessed Spatial Working Memory (SWM) test in Cambridge Neuropsychological Test Automated Battery (CANTAB). The relationship LGI, cognitive performance, clinical variables also explored patient group. Compared controls, exhibited significantly decreased several regions, including postcentral gyrus, precentral middle frontal, superior temporal, insula, parietal, inferior parietal cortex. did worse than SWM measures. Furthermore, left negatively correlated working memory multiple comparison corrections Alcohol-dependent individuals exhibit abnormal patterns gyrification, which may underlying markers AD. Our findings further indicate that deficits related abnormalities addiction.

Language: Английский

Childhood Trauma Exposure is Associated with Decreased Amygdala and Insula Functional Connectivity in Individuals with Alcohol Use Disorder DOI
Primavera A. Spagnolo,

Robin Chholak,

A. F. M. Jalal Ahamed

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
The association between adverse childhood experiences and alterations in brain volume and cortical thickness in adults with alcohol use disorder DOI Creative Commons
Cagdas Türkmen, Haoye Tan, Sarah Gerhardt

et al.

Addiction Biology, Journal Year: 2024, Volume and Issue: 29(9)

Published: Sept. 1, 2024

Previous studies have established a connection between adverse childhood experiences (ACE) and alcohol use disorder (AUD), both of which are associated with alterations in grey matter volume (GMV) cortical thickness (CT). The current study aimed to assess the neurobiological impact ACE specifically context AUD, as well role maltreatment type (i.e., abuse or neglect) timing.

Language: Английский

Citations

3
Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals DOI Creative Commons
Hai-ling Cao, Wei Wei, Yajing Meng

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 220, P. 111166 - 111166

Published: Dec. 10, 2024

Alcohol dependence (AD) is an addictive disorder with multifaceted neurobiological features. Recent research on the pathophysiological mechanisms of AD has emphasized important role dysconnectivity. Cortical gyrification known to be a reliable marker neural connectivity. This study aimed explore cortical using local index (LGI) between alcohol-dependent patients and controls. Magnetic resonance images were collected from 60 early abstinent (5-12 days after stopping alcohol consumption) 59 controls preprocessed FreeSurfer, followed by surface-based morphometry (SBM) analysis compare LGI two groups. Cognitive performance was assessed Spatial Working Memory (SWM) test in Cambridge Neuropsychological Test Automated Battery (CANTAB). The relationship LGI, cognitive performance, clinical variables also explored patient group. Compared controls, exhibited significantly decreased several regions, including postcentral gyrus, precentral middle frontal, superior temporal, insula, parietal, inferior parietal cortex. did worse than SWM measures. Furthermore, left negatively correlated working memory multiple comparison corrections Alcohol-dependent individuals exhibit abnormal patterns gyrification, which may underlying markers AD. Our findings further indicate that deficits related abnormalities addiction.

Language: Английский

Citations

0